 | | Vol. 5.05 – 12 February, 2021 |
| |
|
|
| Researchers examined the single cell expression profiles of hepatic stellate cells purified from the normal livers of foz/foz mice on a chow diet, in NASH with fibrosis of foz/foz mice on a Western diet, and in livers during regression of non‐alcoholic steatohepatitis after switching back to a chow diet.
[Hepatology] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| In vitro experiments were used to investigate the underlying mechanism and function of epithelial cell transforming 2 (ECT2), and the results were confirmed through in vivo experiments.
[Cell Death & Disease] |
|
|
|
| Investigators revealed that cisplatin triggered autophagy in cancer cells, with an increase in BCAT1 expression. The cisplatin-induced up-regulation of BCAT1 decreased the cisplatin sensitivity by regulating autophagy through the mTOR signaling pathway.
[Cell Death & Disease] |
|
|
|
| Scientists established a sensitive lineage tracing system specific for the detection of biliary epithelial cells (BEC)-derived hepatocytes. The BEC-to-hepatocyte transdifferentiation occurred and became minor contributors to hepatocyte homeostasis in a portion of adult individuals.
[iScience] |
|
|
|
| The interactions between small nucleolar RNA host gene 1 (SNHG1) and miR-376, and between miR-376 and forkhead box protein K1 (FOXK1) were predicted and confirmed by dual-luciferase reporter gene and RNA immunoprecipitation assays.
[Molecular Therapy-Oncolytics] |
|
|
|
| The authors evaluated the efficacy of a theranostic platform using a glypican-3 (GPC3)-targeting antibody αGPC3 conjugated to zirconium-89 (89Zr) and yttrium-90 (90Y) to identify, treat, and assess treatment response in a murine model of hepatocellular carcinoma.
[Scientific Reports] |
|
|
|
| Investigators report the effects of liver cancer cell-secreted microvesicles on sorafenib resistance in liver cancer cells HepG2 and Huh7 both in vitro and in vivo.
[Life Sciences] |
|
|
|
| The authors investigated the characteristics of liver cancer cell lines by analyzing the gene expression data available in the Cancer Cell Line Encyclopedia. Unsupervised clustering analysis of 28 liver cancer cell lines yielded two main clusters.
[PLoS One] |
|
 |
|
|
|
| Investigators summarize nonalcoholic steatohepatitis therapies that have progressed to Phase II and beyond. They also discuss some of the potential clinical challenges with the use of these new therapies when approved.
[Nature Reviews Gastroenterology & Hepatology] |
|
|
|
|
| Median Technologies announced the company has signed a research collaboration agreement with the University of California San Diego aimed at carrying out a study that will be used for its proprietary imaging platform iBiopsy® validation.
[Median Technologies] |
|
|
|
| Xeris Pharmaceuticals, Inc. announced that the European Commission has approved Ogluo™ injection for the treatment of severe hypoglycaemia in adults, adolescents, and children aged two years and over with diabetes mellitus.
[Xeris Pharmaceuticals, Inc.] |
|
|
|
|
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
|
|
|
| | Karolinska Institutet – Stockholm, Sweden |
|
|
|
| | University of Connecticut – Storrs, Connecticut, United States |
|
|
|
| | BC Children’s Hospital – Vancouver, British Columbia, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
