 | | Vol. 5.08 – 5 March, 2021 |
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| Cell proliferation tracing revealed that, at the whole hepatocyte–population level, more proliferation was detected in a subset of midzonal hepatocytes during liver homeostasis, with less proliferation in periportal hepatocytes and minimal proliferation in pericentral hepatocytes.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors validated the increased N6‐methyladenosine (m6A) modification and elevated YTHDF1 protein level in sublethal‐heat‐treated hepatocellular carcinoma (HCC) cell lines, HCC patient‐derived xenograft mouse model and patients’ HCC tissues.
[Hepatology] |
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| Researchers found that Sirtuin 2 (SIRT2) was significantly downregulated in livers from advanced NAFLD patients and high‐fat diet (HFD)‐induced non-alcoholic liver disease mice. They revealed that SIRT2 was markedly decreased in obese mice and in palmitate‐treated HepG2 cells.
[Hepatology] |
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| Scientists revealed that USP39 was highly expressed in human hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis. USP39 depletion inhibited HCC cell proliferation and metastasis by promoting ZEB1 degradation.
[Cell Death & Differentiation] |
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| The genetic reintroduction of BLOC1S1 rescued lysosomal tubulation in liver-specific knockout hepatocytes, but not when KIF5B was concurrently depleted.
[Autophagy] |
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| Researchers investigated differential expression of microRNAs between PiZ and control mice and found that miR-34b/c was up-regulated and its levels correlated with intrahepatic Z α1-antitrypsin.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors discovered that targeting EphA2 suppressed both AKT and JAK1/STAT3 signaling, two separate oncogenic pathways in hepatocelllar carcinoma.
[Cell Reports] |
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| Genetic ablation or depletion of PPM1A in cells, organoids, and mice elicited an enhanced Yes-associated protein (YAP)/TAZ cytoplasmic retention and resulted in the diminished cell proliferation, severe gut regeneration defects in colitis, and impeded liver regeneration upon injury.
[PLoS Biology] |
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| Investigators report that TPC2 knockout reduced proliferation of cancer cells in vitro, affected their energy metabolism, and successfully abrogated tumor growth in vivo.
[Cell Chemical Biology] |
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| Researchers investigated the level of human antigen R in the liver of mice fed a normal chow diet and a high-fat diet.
[Cell Death & Disease] |
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| In vitro experiments showed that in the human normal hepatocyte cell line LO2 and primary hepatocytes isolated from mice, overexpression of WW domain-binding protein 2 (WBP2) reduced fat deposition, and knocking out or knocking down WBP2 aggravated PA-induced fat deposition.
[Cell Death & Disease] |
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| Scientists reported that LOC554202 expression was distinctly upregulated in HCC specimens and cell lines.
[Cancer Gene Therapy] |
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| The authors summarize currently available adult cell‐derived hepatobiliary organoid models and their applications.
[Hepatology] |
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| Scientists summarize the latest advances in the understanding of fibroblast growth factor signaling in hepatic fibrosis.
[Liver International] |
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| Tempest Therapeutics, Inc. announced a clinical collaboration agreement with F. Hoffmann-La Roche Ltd. The collaboration will evaluate TPST-1120, Tempest’s small molecule PPAR⍺ antagonist, in combination with atezolizumab and bevacizumab in previously untreated patients with advanced hepatocellular carcinoma.
[Tempest Therapeutics, Inc.] |
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| April 21 – 23, 2021
Virtual |
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| | Shanghai Jiao Tong University School of Medicine- Shanghai, China |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | CyberCoders – San Diego, California, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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