 | | Vol. 5.08 – 12 March, 2021 |
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| Scientists investigated the novel cellular crosstalk among carcinoma-associated fibroblasts, tumor cells, and tumor‐associated neutrophils during different stages of hepatocellular carcinoma pathogenesis.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers conducted a longitudinal study of the role of HBV preS mutations on development of hepatocellular carcinoma, particularly in chronic hepatitis B patients having low HBV DNA or ALT levels, and investigated effects of secretion‐defective preS2 deletion mutant on hepatocyte damage in vitro and liver fibrosis in vivo.
[Hepatology] |
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| Human embryonic stem cells were induced to differentiate into hepatocytes along hepatic lineages to mimic liver development in vitro.
[Nature Communications] |
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| A liver‐on‐a‐chip platform with bioengineered multicellular liver microtissues was developed, composed of four major types of liver cells to implement a human hepatic fibrosis model driven by non‐alcoholic fatty liver disease.
[Small] |
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| Scientists suggested that fat could induce glucose-mediated metabolic changes in non-transformed liver cells similar to those found in hepatocellular carcinoma.
[Cancer Research] |
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| A distinct heterogeneity in GASC1 levels was observed among hepatocellular carcinoma cell populations, predicting their inherent high or low tumor-initiating capacity.
[Cell Death & Disease] |
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| Mimicking the miR‐188‐5p resulted in the up‐regulation of hepatic stellate cell (HSC) activation and proliferation by directly targeting the phosphatase and tensin homolog (PTEN). Inhibition of miR‐188‐5p reduced the activation and proliferation markers of HSCs through PTEN/AKT pathway.
[Journal of Cellular and Molecular Medicine] |
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| Investigators applied core–shell bioprinting to establish tailored 3D co-culture models for hepatocytes. The bioinks were specifically functionalized with natural matrix components and used to co-print fibroblasts and hepatocytes in a spatially defined, coaxial manner.
[Scientific Reports] |
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| Researchers cocultured human-induced pluripotent stem cell-derived intestinal cells and fresh human hepatocytes which were isolated from PXB mice with medium circulation in a pneumatic-pressure-driven microphysiological systems with pipette-friendly liquid-handling options.
[Scientific Reports] |
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| The authors discuss the hepatotropism of SARS-CoV-2, including the differential expression of viral receptors on liver cell types.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists summarize recent studies that discuss and explore the role of SHC1 in the occurrence and progression of liver diseases. They also provide a theoretical basis for future studies.
[Life Sciences] |
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| HepaTx Corporation, Namocell Inc., and Takara Bio USA, Inc. announced successful completion of the second phase of their collaboration on single cell analysis of hepatocyte-like cells differentiated from adipose tissue-derived stromal cells using Namocell’s Single Cell Dispensers and Takara Bio’s SMART-seq® kits to characterize HepaTx’s novel cell therapies for liver disease.
[HepaTx Corporation (PR Newswire, LLC.)] |
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| June 14 – 18, 2021
Virtual |
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| | Shanghai Jiao Tong University School of Medicine- Shanghai, China |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | CyberCoders – San Diego, California, United States |
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