Hepatic Cell News Volume 5.11 | Mar 26 2021

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    2021-02-18 | HCN 5.11


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.11 – 26 March, 2021
    TOP STORY

    Tumor Necrosis Factor‐α‐Induced Protein 8‐like 2 Alleviates Nonalcoholic Fatty Liver Disease via Suppressing TAK1 Activation

    Tumor necrosis factor‐α‐induced protein 8‐like 2 suppressed nonalcoholic fatty liver disease (NAFLD) advancement by blocking transforming growth factor‐beta‐activated kinase 1‐c‐Jun NH2‐terminal kinase/p38 pathway and was a promising target molecule for NAFLD therapy.
    [Hepatology]

    Abstract

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    A Tumor-Suppressive Circular RNA Mediates Uncanonical Integrin Degradation by the Proteasome in Liver Cancer

    Investigators showed that polyadenylate-binding protein 1 (circPABPC1) was preferentially lost in tumor cells from clinical samples and inhibited both intrahepatic and distant metastases in a mouse xenograft model.
    [Science Advances]

    Full Article

    DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer

    Researchers showed that checkpoint kinase 2 (CHK2), a central effector of DNA damage response, regulated cellular energy production by affecting glycolysis and mitochondrial functions.
    [Cancer Research]

    Abstract

    E3 Ubiquitin Ligase Grail Promotes Hepatic Steatosis through Sirt1 Inhibition

    Scientists demonstrated that gene related to anergy in lymphocytes regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1.
    [Cell Death & Disease]

    Full Article

    S-Adenosylmethionine Upregulates the Angiotensin Receptor-Binding Protein ATRAP via the Methylation of HuR in NAFLD

    The authors explored the effect of supplementary S-adenosylmethionine, which was the main biological methyl donor in mammalian cells, in regulating AT1R-associated protein (ATRAP), which was the negative regulator of AT1R.
    [Cell Death & Disease]

    Full Article

    Interferon Regulatory Factor 1 (IRF-1) Downregulates Checkpoint Kinase 1 (CHK1) through miR-195 to Upregulate Apoptosis and PD-L1 Expression in Hepatocellular Carcinoma (HCC) Cells

    IRF-1 induced miR-195 to suppress CHK1 protein expression. Both increased IRF-1 and decreased CHK1 upregulate cellular apoptosis and PD-L1 expression in HCC.
    [British Journal of Cancer]

    Abstract

    N-n-Butyl Haloperidol Iodide Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation in Mice

    Researchers revealed that c-Jun was bound to the TGF-β receptor II (TGFBR2) promoter, whereas N-n-Butyl haloperidol iodide suppressed the binding of c-Jun to the TGFBR2 promoter to restrain TGF-β signaling and inhibit α-smooth muscle actin and collagen I upregulation.
    [Acta Pharmacologica Sinica]

    Abstract

    LINC01419-Mediated Epigenetic Silencing of ZIC1 Promotes Metastasis in Hepatocellular Carcinoma through thePI3K/Akt Signaling Pathway

    LINC01419 enhanced the methylation of zinc finger of the cerebellum (ZIC1) promoter, inhibited ZIC1 expression, and activated the PI3K/Akt signaling pathway, thereby enhancing the malignant phenotypes of hepatocellular carcinoma cells in vitro as well as tumor formation and metastasis in vivo.
    [Laboratory Investigation]

    Abstract

    Peptide-Based Scaffolds for the Culture and Maintenance of Primary Human Hepatocytes

    Scientists report the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes.
    [Scientific Reports]

    Full Article

    Liver Alanine Catabolism Promotes Skeletal Muscle Atrophy and Hyperglycaemia in Type 2 Diabetes

    Researchers revealed a metabolic inter-tissue cross-talk that linked skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
    [Nature Metabolism]

    Abstract

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    REVIEWS

    Direct and Indirect Control of Hepatic Glucose Production by Insulin

    The authors make the case that physiologically direct hepatic insulin action dominates acute suppression of glucose production, but that there is also a delayed, second order regulation of this process via extrahepatic effects.
    [Cell Metabolism]

    Abstract

    INDUSTRY AND POLICY NEWS

    Terns Announces Initiation of Dosing in Phase I Clinical Trial of TERN-501, its THR-Beta Agonist in Development for the Treatment of NASH

    Terns Pharmaceuticals, Inc. announced the initiation of dosing in a Phase I clinical trial evaluating TERN-501, a selective thyroid hormone receptor beta (THR-β) agonist with high metabolic stability, enhanced liver distribution and greater selectivity for THR-β when compared with other THR-β agonists in development.
    [Terns Pharmaceuticals, Inc. (Intrado GlobeNewswire LLC.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Liver

    Spark Therapeutics – Philadelphia, Pennsylvania, United States

    Postdoctoral Scientist – Senescence and Cancer

    Cancer Research Center of Lyon – Lyon, France

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

    Postdoctoral Associate – NAFLD and Hepatocellular Carcinoma

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Immunogenetics and Tumor Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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