| TOP STORY | T-Cell Response against Varicella-Zoster Virus in Fingolimod-Treated MS Patients Investigators studied the immune response against varicella-zoster virus (VZV) in patients with multiple sclerosis (MS) before and during fingolimod therapy. The VZV-specific immune response was studied using interferon (IFN)-γ enzyme-linked immunosorbent spot assay, proliferation assays, and upregulation of T-cell activation markers in patients before and after three months of fingolimod therapy, in untreated and IFN-β-treated patients with MS, and in healthy controls. [Neurology] Abstract |
| PUBLICATIONS (Ranked by impact factor of the journal) | IL-22-Producing CD4+ Cells Are Depleted in Actively Inflamed Colitis Tissue Scientists analyzed cells from the colon of inflammatory bowel disease patients and showed that Crohn’s disease patients had significantly elevated numbers of interleukin (IL)-17+, CD4+ cells compared with healthy controls and ulcerative colitis patients, but these numbers did not vary based on the inflammatory status of the mucosa. [Mucosal Immunol] Full Article Fasting and Meal-Stimulated Residual Beta Cell Function Is Positively Associated with Serum Concentrations of Proinflammatory Cytokines and Negatively Associated with Anti-Inflammatory and Regulatory Cytokines in Patients with Longer Term Type 1 Diabetes The authors investigated whether systemic proinflammatory, anti-inflammatory and regulatory cytokines associated differently with fasting and meal-stimulated beta cell function in patients with longer term type 1 diabetes. [Diabetologia] Abstract Erosive Rheumatoid Arthritis Is Associated with Antibodies that Activate PAD4 by Increasing Calcium Sensitivity Scientists discovered a subset of anti-peptidylarginine deiminase 4 (PAD4) autoantibodies that markedly increase the catalytic efficiency of PAD4 by decreasing the enzyme’s requirement for calcium into the physiologic range. Patients with these PAD3/PAD4 cross-reactive autoantibodies had higher baseline radiographic damage scores and a higher likelihood of radiographic progression compared to individuals negative for these antibodies. [Sci Transl Med] Abstract | Press Release Phospholipase D1 Has a Pivotal Role in IL-1β-Driven Chronic Autoimmune Arthritis through Regulation of NFκB, HIF-1α and FoxO3a Researchers showed for the first time that phospholipase D1 (PLD1) but not PLD2, is selectively upregulated in the IL-1β-stimulated synoviocytes as well as synovium from rheumatoid arthritis patients. [Mol Cell Bio] Abstract Roles of the Ubiquitin Peptidase USP18 in Multiple Sclerosis and the Response to Interferon-β Treatment Two polymorphisms, rs2542109 and rs9618216, were genotyped in a cohort of 691 relapse-onset multiple sclerosis (MS) patients and 1028 healthy controls and in 225 MS patients treated with interferonβ and classified into responders and non-responders after two years of treatment according to clinical criteria. [Eur J Neurol] Abstract CD4+ T Cells Producing Interleukin (IL)-17, IL-22 and Interferon-γ Are Major Effector T Cells in Nickel Allergy Researchers aimed to determine the frequencies of CD4+ , CD8+ and γδ T cells producing IL-17, IL-22 and interferon-γ in the blood and skin from nickel-allergic patients. [Contact Dermatitis] Abstract Up-Regulation of Slc39A2(Zip2) mRNA in Peripheral Blood Mononuclear Cells from Patients with Pulmonary Tuberculosis Scientists investigated whether Zip2 level was changed in the patients with pulmonary tuberculosis (PTB). Zip2 mRNA and protein levels in peripheral blood mononuclear cells from PTB and healthy controls were detected by quantitative real-time PCR and western blot, respectively. [Mol Biol Rep] Abstract Decreased ITGAM and FcγRIIIA mRNA Expression Levels in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus The authors investigated the association of mRNA expression levels of ITGAM and FCγRIIIA with systemic lupus erythematosus (SLE). Real-time transcription-polymerase chain reaction analysis was used to determine the expression levels of ITGAM and FCγRIIIA mRNA in peripheral blood mononuclear cells from 60 patients with SLE and 60 healthy controls. [Clin Exp Med] Abstract Don’t forget to subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |
| REVIEWS | Immunology of Age-Related Macular Degeneration This review discusses recent discoveries related to the immunological aspects of age-related macular degeneration (AMD) pathogenesis. The authors outline the diverse immune cell types, inflammatory activators and pathways that are involved. They also discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population. [Nat Rev Immunol] Abstract The Emerging Role of MicroRNAs in the Pathogenesis of Systemic Lupus Erythematosus This review focuses on the current understanding of microRNA (miRNA) biogenesis, the role of miRNAs in the regulation of systemic lupus erythematosus pathogenesis, with special emphasis on new advances and the association of miRNAs with DNA methylation. [Cell Signal] Abstract Celiac Disease and Autoimmunity: Review and Controversies The authors provide a brief overview of the pathogenesis of celiac disease (CD) and review the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases. [Curr Allergy Asthma Rep] Full Article Visit our reviews page to see a complete list of reviews in the human immunology research field. |
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