Dietary Gluten Triggers Concomitant Activation of CD4+ and CD8+ αβ T cells and γδ T Cells in Celiac Disease Scientists showed that gluten exposure also induces the appearance of activated, gut-homing CD8+ αβ and γδ T cells in the peripheral blood. Single-cell T-cell receptor sequence analysis indicates that both of these cell populations have highly focused T-cell receptor repertoires, indicating that their induction is antigen-driven. [Proc Natl Acad Sci USA] Abstract Premature Cell Senescence and T Cell Receptor-Independent Activation of CD8+ T Cells in Juvenile Idiopathic Arthritis CD8+ T cells lacking CD28 were originally reported to be a characteristic feature of juvenile idiopathic arthritis (JIA), but the relevance of these unusual cells to this disease remains to be elucidated. Because of recent evidence that loss of CD28 cells is typical of terminally differentiated lymphocytes, the authors aimed to examine functional subsets of CD8+ T cells in patients with JIA. [Arthritis Rheum] Abstract | Press Release T Cells in the Human Metastatic Melanoma Microenvironment Express Site-Specific Homing Receptors and Retention Integrins Scientists hypothesized that T cells in the melanoma microenvironment would be enriched for chemokine receptors CCR4, CCR5, CXCR3, and homing receptors relevant to the tissue site. Viably cryopreserved single cell suspensions from 19 melanoma metastases representing three metastatic sites (tumor-infiltrated lymph node, skin, and small bowel) were evaluated by multiparameter flow cytometry and compared to benign lymph nodes and peripheral blood mononuclear cells from patients with Stage IIB-IV melanoma. [Int J Cancer] Abstract Lack of Recall Response to Tax in ATL and HAM/TSP Patients but Not in Asymptomatic Carriers of Human T-Cell Leukemia Virus Type 1 A patient cohort (from human T-cell leukemia virus type 1 [HTLV-1] endemic region) consisting of seronegative controls, asymptomatic carriers, and patients with adult T-cell leukemia (ATL) or HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was analyzed for CD8+ T cells polyfunctionality in response to the viral antigen Tax. [J Clin Immunol] Abstract Systemic Lupus Erythematosus Complicating Autoimmune Pulmonary Alveolar Proteinosis that Was Worsened by Immunosuppressive Therapy A 26-year-old Japanese woman developed autoimmune pulmonary alveolar proteinosis (PAP) during glucocorticoid therapy for systemic lupus erythematosus (SLE). Intensive immunosuppressive therapy worsened the PAP. De-escalation of immunosuppressive therapy improved the PAP. [Lupus] Abstract Glucocorticoid Downregulates Expression of IL-12 Family Cytokines in Systemic Lupus Erythematosus Patients Researchers investigated expression of interleukin 12 (IL-12) family cytokines IL-12, IL-23, IL-27 and IL-35 in systemic lupus erythematosus patients and the effect of glucocorticoid treatment on their expression. [Lupus] Abstract High Capacity for Leukotriene Biosynthesis in Peripheral Blood during Pregnancy The authors showed that pregnancy affects leukotriene synthesis in human blood and leukocytes. 5-Lipoxygenase product formation in stimulated blood of pregnant women was significantly higher than in non-pregnant females. [Prostaglandins Leukot Essent Fatty Acids] Abstract |