Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs Using human bone biopsy specimens, the authors provided evidence of hematopoietic stem cell (HSC) propensity to localize to endosteal regions of the trabecular bone area. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release The Autoimmune Disease-Associated SNP rs917997 of IL18RAP Controls IFNγ Production by PBMC Scientists analyzed responsiveness to IL-18 in type 1 diabetes, and the effect of rs917997 genotype on IL18RAP gene expression post-activation. Upon IL-12 and IL-18 treatment, peripheral blood mononuclear cells (PBMCs) from subjects carrying susceptibility alleles at rs917997 produced higher levels of IFNγ than those with protective genotypes. [J Autoimmun] Abstract IL-4-, TGF-β-, and IL-1-Dependent Expansion of Parasite Antigen-Specific Th9 Cells Is Associated with Clinical Pathology in Human Lymphatic Filariasis Researchers identified a population of IL-9 and IL-10 coexpressing cells (lacking IL-4 expression) in normal individuals. These cells respond to antigenic and mitogenic stimulation, but are distinct from IL-9+ Th2 cells. [J Immunol] Abstract Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus Scientists prospectively evaluated mitochondrial dysfunction and mechanistic target of rapamycin activation in PBLs relative to the Systemic Lupus Erythematosus Disease Activity Index during 274 visits of 59 patients and 54 matched healthy subjects. [J Immunol] Abstract Innate Immune Recognition of Molds and Homology to the Inner Ear Protein, Cochlin, in Patients with Autoimmune Inner Ear Disease Investigators examined whether an environmental exposure to mold in autoimmune inner ear disease patients is sufficient to generate a pro-inflammatory response that may, in part, explain periods of acute exacerbation of disease. They hypothesized that molds may stimulate an aberrant immune response in these patients as both several Aspergillus species and penecillium share homology with the LCCL domain of the inner ear protein, cochlin. [J Clin Immunol] Abstract Upregulation of the Inhibitory Receptor ILT4 in Monocytes from Septic Patients Immunoglobulinlike transcript 4 (ILT4) expression, endotoxin-induced IL-12 and IL-10 production and CD86 expression were investigated in circulating monocytes from sixteen patients with severe sepsis and sixteen age and sex matched controls. [Hum Immunol] Abstract Increased IL-23 and IL-17 Expression by Peripheral Blood Cells of Patients with Primary Biliary Cirrhosis Researchers investigated the expression of IL-23 and IL-17 in the peripheral blood of patients with primary biliary cirrhosis and its clinical significance. [Cytokine] Abstract Efficient Depletion of Chronic Lymphocytic Leukemia B Cells Using Serial Rounds of Immunomagnetic Depletion Investigators depleted leukemic B cells using a modified protocol comprising serial rounds of depletion using immunomagnetic beads at reduced bead to cell ratios. This resulted in more effective B cell depletion with the use of fewer immunomagnetic beads, and without affecting viability or yield of non-B cells. [J Immunol Methods] Abstract |