OX40 Is a Potent Immune Stimulating Target in Late Stage Cancer Patients Patients treated with one course of anti-OX40 monoclonal antibody showed an acceptable toxicity profile and regression of at least one metastatic lesion in 12/30 patients. Mechanistically, this treatment increased T and B cell responses to reporter antigen immunizations, led to preferential upregulation of OX40 on CD4+ FoxP3+ regulatory T cells in tumor-infiltrating lymphocytes and increased the anti-tumor reactivity of T and B cells in patients with melanoma. [Cancer Res] Abstract Neutrophil Uptake of Nitrogen-Bisphosphonates Leads to the Suppression of Human Peripheral Blood γδ T Cells Investigators showed that neutrophils present in human peripheral blood readily take up zoledronate, and this phenomenon is associated with the potent immune suppression of human peripheral blood Vγ9Vd2 T cells. [Cell Mol Life Sci] Abstract Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus Using immunoelectron microscopy, researchers showed that Fas ligand (FasL) and TRAIL are expressed on the limiting membrane of multivesicular bodies where, by membrane invagination, intraluminal microvesicles carrying membranal bioactive FasL and TRAIL are formed and released in the extracellular space as exosomes. [J Immunol] Abstract Intratumoral Regulatory T Cells Upregulate Immunosuppressive Molecules in Head and Neck Cancer Patients Tumor-infiltrating lymphocytes and peripheral blood lymphocytes were isolated from a cohort of head and neck squamous cell carcinoma patients. The immunosuppressive phenotypes and function of intratumoral regulatory T cells (Treg) were compared with those of peripheral blood Treg. [Br J Cancer] Abstract Durable Antibody Responses Following One Dose of the Bivalent Human Papillomavirus L1 Virus-Like Particle Vaccine in the Costa Rica Vaccine Trial The Costa Rica HPV16/18 Vaccine Trial showed that four-year vaccine efficacy against 12-month HPV16/18 persistent infection was similarly high among women who received one, two, or the recommended three doses of the bivalent HPV16/18 L1 virus-like particle vaccine. Live-attenuated viral vaccines, but not simple-subunit vaccines, usually induce durable lifelong antibody responses after a single dose. [Cancer Prev Res] Abstract | Press Release Differential CTLA-4 Expression in Human CD4+ versus CD8+ T Cells Is Associated with Increased NFAT1 and Inhibition of CD4+ Proliferation The authors analyzed cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) in normal human CD4+ and CD8+ T-cell subsets and showed for the first time that CTLA-4 is expressed significantly higher in the CD4+ T cells than in CD8+ T cells. CTLA-4 is higher at the protein and the transcriptional levels in CD4+ T cells. [Genes Immun] Abstract Critical Role of Spatial Interaction between CD8+ and Foxp3+ Cells in Human Gastric Cancer: The Distance Matters Researchers investigated the concurrent spatial distribution pattern of CD8+ and FoxP3+ tumor-infiltrating lymphocytes and their prognostic impact in human gastric cancer. [Cancer Immunol Immunother] Abstract Adjuvant System AS02V Enhances Humoral and Cellular Immune Responses to Pneumococcal Protein PhtD Vaccine in Healthy Young and Older Adults: Randomized, Controlled Trials Researchers evaluated humoral and cellular immune responses and safety/reactogenicity following immunization with neumococcal histidine triad protein D vaccine with or without adjuvant (alum or AS02V) in older (=65 years) and young (18-45 years) healthy adults. [Vaccine] Abstract APL-1, an Altered Peptide Ligand Derived from Human Heat-Shock Protein 60, Selectively Induces Apoptosis in Activated CD4+ CD25+ T Cells from Peripheral Blood of Rheumatoid Arthritis Patients Scientists investigated the ability of APL-1 in inducing apoptosis in PBMCs from rheumatoid arthritis (RA) patients, who were classified as active or inactive according to their DAS28 score. APL-1 decreased the viability of PBMCs from active but not from inactive RA patients. DNA fragmentation assays and typical morphological features clearly demonstrated that APL-1 induced apoptosis in these cells. [Int Immunopharmacol] Abstract Effects of Vitamin D3, Calcipotriol and FTY720 on the Expression of Surface Molecules and Cytolytic Activities of Human Natural Killer Cells and Dendritic Cells Researchers describe the effects of three drugs that are either approved or have the potential for treating multiple sclerosis patients through the in vitro activities of human natural killer (NK) cells and dendritic cells (DCs). Their results indicate that 1,25(OH)2D3, the biologically active metabolite of vitamin D3, calcipotriol and FTY720 augment IL-2-activated NK cell lysis of K562 and RAJI tumor cell lines as well as immature and mature DCs, with variable efficacies. [Toxins] Abstract | Full Article |