B Cell Resistance to Fas-Mediated Apoptosis Contributes to Their Ineffective Control by Regulatory T Cells in Rheumatoid Arthritis Researchers investigated whether regulatory T cells (Treg) can control B cell function in rheumatoid arthritis (RA) and if not to explore the basis for this defect. Suppression of B cell responses by Treg was analyzed in vitro by flow cytometry and ELISA using peripheral blood mononuclear cells from 65 patients with RA and 41 sex-matched and aged-matched healthy volunteers. [Ann Rheum Dis] Abstract Reciprocal Activation of CD4+T Cells and Synovial Fibroblasts by SDF-1 Promotes RANKL Expression and Osteoclastogenesis in Rheumatoid Arthritis The authors found coexpression of receptor activator of nuclear factor ĸB ligand (RANKL), tumor necrosis factor (TNF)- and stromal cell-derived factor (SDF-1) in lining and sublining area of rheumatoid arthritis (RA) synovium. SDF-1 stimulated RANKL expression in RA synovial fibroblasts and CD4+ T cells, and TNF- inhibition reduced this stimulation. [Arthritis Rheum] Abstract CD24hiCD27+ B Cells from Allergic Asthma Patients Have Impaired Regulatory Activity in Response to LPS The frequency and function of IL-10 producing B cell subsets in allergic asthma was investigated. Isolated peripheral blood B cells from 13 allergic asthma patients and matched controls were analyzed for the expression of different regulatory B cell markers. [Clin Exp Allergy] Abstract Immune Response Profiling in Early Rheumatoid Arthritis: Discovery of a Novel Interaction of Treatment Response with Viral Immunity Researchers aimed to identify immune response signatures that correlate with clinical treatment outcomes in patients with rheumatoid arthritis (RA). A cohort of 71 consecutive patients with early RA starting treatment with disease-modifying antirheumatic drugs was recruited. [Arthritis Res Ther] Abstract | Full Article Two Wheat Decapeptides Prevent Gliadin-Dependent Maturation of Human Dendritic Cells Scientists monitored the effect of peptic-tryptic digest of gliadin (PT-gliadin) on the maturation of human monocyte-derived dendritic cells (DC) and the impact of pDAV and pRPQ decapeptides in the modulation of PT-gliadin-induced phenotypic and functional DC maturation. [Exp Cell Res] Abstract Expression of Human T Cell Immunoglobulin Domain and Mucin-3 (TIM-3) on Kidney Tissue from Systemic Lupus Erythematosus (SLE) Patients Investigators aimed to evaluate the expression of TIM-3 in renal tissue from patients with SLE and patients without SLE, and to determine the difference of TIM-3 expression between them. [Cin Exp Med] Abstract Impaired and Imbalanced Cellular Immunological Status Assessed in Advanced Cancer Patients and Restoration of the T Cell Immune Status by Adoptive T-Cell Immunotherapy The authors performed a detailed evaluation of the immunological status of 47 patients with advanced solid cancer, who had received no immunosuppressive treatment, and compared the results with 32 healthy subjects. [Int Immunopharmacol] Abstract Histamine Downregulates the Th1-Associated Chemokine Interferon-γ-Induced Protein in Monocytes and Myeloid Dendritic Cells Monocytes and myeloid dendritic cells were isolated from human PBMC. Histamine receptor expression was evaluated by real-time PCR. Cells were stimulated with histamine and histamine receptor ligands, and restimulated with polyinosinic-polycytidylic acid, and supernatants were analyzed by protein array and ELISA. [Int Arch Allergy Immunol] Full Article
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