| Vol. 10.00 – 4 January, 2022 |
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| A comprehensive data collection of tumor immunity-associated functional screens was performed. Large-scale genomic data sets were exploited to conduct integrative analyses. [Molecular Cancer] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined the role of the CD137+ T cells in the improvement of patients’ selection for immunotherapy treatment. [Clinical Cancer Research] |
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| Investigators demonstrated that teprotumumab, an anti-insulin-like growth factor I receptor inhibitor, attenuated constitutive expression and induction by the thyroid-stimulating hormone of MHC II and these B7 members in CD34+ fibrocytes. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Immunoglobulin treatment-experienced subjects with primary immunodeficiency received 52 weeks of Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (IGSC 20%) given weekly at the same dose as the subject’s previous IgG regimen; the minimum dose was 100 mg/kg/week. [Journal of Clinical Immunology] |
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| Researchers established an experimental system including a stimulus of interest, applied to an immune cell type in several contexts. [Cell Discovery] |
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| Efforts have been made to generate immune-escaping human embryonic stem cells where T cell immunity is evaded by defecting β-2-microglobulin, a common unit for human leukocyte antigen class I, and NK cells were inhibited via ectopic expression of HLA-E or -G. [International Journal of Biological Sciences] |
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| By investigating public databases containing locally advanced rectal cancer (LARC) patient data, CXC chemokine ligand 12 (CXCL12) expression was correlated with poor prognosis, immune cell infiltration, epithelial- mesenchymal transition, and angiogenesis in LARC. [Journal of Cancer] |
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| Human peripheral blood mononuclear cells were stimulated with macrophage colony-stimulating factor, and obtained macrophages were transformed into foam cells by oxidized low-density lipoprotein. [Proteome Science] |
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| Scientists demonstrated that papaya mosaic (PapMV) virus nanoparticles did not require the transporter associated with antigen presentation, but rather depended on lysosome acidification and cathepsin S protease activity for presentation of the T cell epitope. [PLoS One] |
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| The authors summarize and detail clinical and experimental evidence for, and underlying mechanisms of, the dual impact of neutrophils’ functions, both supporting and inhibiting cancer development. [Seminars in Immunology] |
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| Providing information on how genetic variations affect the skin immune system may reduce uncertainties in estimating chemical hazards/risks for human health in the future. [Journal of Toxicology and Environmental Health-Part B-Critical Reviews] |
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| NaNotics LLC announced a research collaboration with Mayo Clinic to develop a NaNot that targets the soluble form of PD-L1, a tumor-generated immune inhibitor. [NaNotics LLC (BusinessWire, Inc.)] |
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| ImmunityBio, Inc. has been granted a US patent for a novel NK cell therapy composition and method for treating cancer that combines the company’s genetically modified NK-92 cells with CD16 receptors to enhance binding and activity of monoclonal antibodies. [ImmunityBio, Inc.] |
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| February 5 – 9, 2022 Maui, Hawaii, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Centre for Immunology & Infection Limited – Hong Kong, China |
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| Memorial Sloan Kettering – New York City, New York, United States |
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| Allen Institute – Seattle, Washington, United States |
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| King’s College London – London, England, United Kingdom |
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