Human Immunology News Volume 10.00 | Jan 4 2021

    0
    61







    2022-01-04 | HIN 10.00


    Human Immunology News by STEMCELL Technologies
    Vol. 10.00 – 4 January, 2022
    TOP STORY

    Integrative Analysis of CRISPR Screening Data Uncovers New Opportunities for Optimizing Cancer Immunotherapy

    A comprehensive data collection of tumor immunity-associated functional screens was performed. Large-scale genomic data sets were exploited to conduct integrative analyses.
    [Molecular Cancer]

    Full Article
    Request your free copy of the 'Human Immune Cytokines' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Cancer Patients

    Researchers examined the role of the CD137+ T cells in the improvement of patients’ selection for immunotherapy treatment.
    [Clinical Cancer Research]

    AbstractFull Article

    Therapeutic IGF-I Receptor Inhibition Alters Fibrocyte Immune Phenotype in Thyroid-Associated Ophthalmopathy

    Investigators demonstrated that teprotumumab, an anti-insulin-like growth factor I receptor inhibitor, attenuated constitutive expression and induction by the thyroid-stimulating hormone of MHC II and these B7 members in CD34+ fibrocytes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    A Multi-Center, Open-Label, Single-Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency

    Immunoglobulin treatment-experienced subjects with primary immunodeficiency received 52 weeks of Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (IGSC 20%) given weekly at the same dose as the subject’s previous IgG regimen; the minimum dose was 100 mg/kg/week.
    [Journal of Clinical Immunology]

    Full Article

    A Multivariate Modeling Framework to Quantify Immune Checkpoint Context-Dependent Stimulation on T Cells

    Researchers established an experimental system including a stimulus of interest, applied to an immune cell type in several contexts.
    [Cell Discovery]

    Full Article

    Engineering of Human Mesenchymal Stem Cells Resistant to Multiple Natural Killer Subtypes

    Efforts have been made to generate immune-escaping human embryonic stem cells where T cell immunity is evaded by defecting β-2-microglobulin, a common unit for human leukocyte antigen class I, and NK cells were inhibited via ectopic expression of HLA-E or -G.
    [International Journal of Biological Sciences]

    Full ArticleGraphical Abstract

    Elevated CXCL12 in the Plasma Membrane of Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiotherapy: A Potential Prognostic Marker

    By investigating public databases containing locally advanced rectal cancer (LARC) patient data, CXC chemokine ligand 12 (CXCL12) expression was correlated with poor prognosis, immune cell infiltration, epithelial- mesenchymal transition, and angiogenesis in LARC.
    [Journal of Cancer]

    Full ArticleGraphical Abstract

    TMT-Based Quantitative Proteomic Profiling of Human Monocyte-Derived Macrophages and Foam Cells

    Human peripheral blood mononuclear cells were stimulated with macrophage colony-stimulating factor, and obtained macrophages were transformed into foam cells by oxidized low-density lipoprotein.
    [Proteome Science]

    Full Article

    MHC Class I Antigen Cross-Presentation Mediated by PapMV Nanoparticles in Human Antigen-Presenting Cells Is Dependent on Autophagy

    Scientists demonstrated that papaya mosaic (PapMV) virus nanoparticles did not require the transporter associated with antigen presentation, but rather depended on lysosome acidification and cathepsin S protease activity for presentation of the T cell epitope.
    [PLoS One]

    Full Article
    Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart
    REVIEWS

    The Dual Role of Neutrophils in Cancer

    The authors summarize and detail clinical and experimental evidence for, and underlying mechanisms of, the dual impact of neutrophils’ functions, both supporting and inhibiting cancer development.
    [Seminars in Immunology]

    Abstract

    Genetic Variants Affecting Chemical Mediated Skin Immunotoxicity

    Providing information on how genetic variations affect the skin immune system may reduce uncertainties in estimating chemical hazards/risks for human health in the future.
    [Journal of Toxicology and Environmental Health-Part B-Critical Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    NaNotics to Collaborate with Mayo Clinic on Nanomedicine Cancer Treatment

    NaNotics LLC announced a research collaboration with Mayo Clinic to develop a NaNot that targets the soluble form of PD-L1, a tumor-generated immune inhibitor.
    [NaNotics LLC (BusinessWire, Inc.)]

    Press Release

    ImmunityBio Awarded Seminal Patent on Natural Killer Cells

    ImmunityBio, Inc. has been granted a US patent for a novel NK cell therapy composition and method for treating cancer that combines the company’s genetically modified NK-92 cells with CD16 receptors to enhance binding and activity of monoclonal antibodies.
    [ImmunityBio, Inc.]

    Press Release
    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    February 5 – 9, 2022
    Maui, Hawaii, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Breast Cancer Immunology and Immunotherapy

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Research Assistant – Vaccine Development

    Centre for Immunology & Infection Limited – Hong Kong, China

    Postdoctoral Researcher – CAR T Cells Engineered to Treat Multiple Myeloma

    Memorial Sloan Kettering – New York City, New York, United States

    Scientist – Single Cell Technologies

    Allen Institute – Seattle, Washington, United States

    Research Associate – HIV Replication

    King’s College London – London, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter