Human Immunology News Volume 10.01 | Jan 11 2022

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    2021-01-11 | HIN 10.01


    Human Immunology News by STEMCELL Technologies
    Vol. 10.01 – 11 January, 2022
    TOP STORY

    Naive T Cell Depletion to Prevent Chronic Graft-Versus-Host Disease

    138 patients with acute leukemia received Naive T cell-depleted peripheral blood stem-cell from HLA-matched related or unrelated donors following conditioning with high- or intermediate-dose total-body irradiation and chemotherapy.
    [Journal of Clinical Oncology]

    Abstract
    Download the cell separation e-book, a practical guide on everything you need to know about cell isolation techniques.
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    Three Tissue Resident Macrophage Subsets Coexist across Organs with Conserved Origins and Life Cycles

    Monocyte-derived macrophages contributed to the resident macrophage population until they reached a defined upper limit after which they did not outcompete pre-existing resident macrophages.
    [Science Immunology]

    Full Article

    Prediction of Biomarkers and Therapeutic Combinations for Anti-PD-1 Immunotherapy Using the Global Gene Network Association

    Prediction identified genes and pathways known to be associated with anti-PD1, and was further validated by six CRISPR gene sets associated with tumor resistance to cytotoxic T cells and targets of the 36 compounds that had been tested in clinical trials for combination treatments with anti-PD1.
    [Nature Communications]

    Full Article

    A GATA4-Regulated Secretory Program Suppresses Tumors through Recruitment of Cytotoxic CD8 T Cells

    Investigators found that GATA4 promoted non-cell autonomous tumor suppression in multiple model systems. Mechanistically, they showed that Gata4-dependent tumor suppression required cytotoxic CD8 T cells and partially required the secreted chemokine CCL2.
    [Nature Communications]

    Full Article

    The Landscape of Human Tissue and Cell Type Specific Expression and Co-Regulation of Senescence Genes

    The authors performed an integrative gene network analysis of bulk and single-cell RNA-seq data in non-diseased human tissues to investigate senescence gene co-expression signatures and their cell-type specificity.
    [Molecular Neurodegeneration]

    Full Article

    Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-Cell Activation

    Researchers combined intratumoral STimulator of INterferon Genes (STING) agonist therapy with systemically injected extended half-life IL2 and anti–PD-1 checkpoint blockade to drive innate and adaptive antitumor immunity in models of triple-negative breast cancer.
    [Cancer Immunology Research]

    Full Article

    Human MuStem Cells Repress T Cell Proliferation and Cytotoxicity through Both Paracrine and Contact-Dependent Pathways

    The impact of human MuStem cells or their secretome on the proliferative and phenotypic properties of T cells was explored by co-culture experiments with either peripheral blood mononucleated cells or CD3-sorted T cells.
    [Stem Cell Research & Therapy]

    Full Article

    TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma

    Scientists examined the effect of selectively blocking the function of sCTLA-4 on in vitro immune responses from volunteer healthy or melanoma patient PBMC samples.
    [Frontiers in Immunology]

    Full Article

    Immune Subtypes and Neoantigen-Related Immune Evasion in Advanced Colorectal Cancer

    To understand the systemic immune response in advanced untreated primary colorectal cancer, researchers analyzed immune subtypes and immune evasion via neoantigen-related mechanisms.
    [iScience]

    AbstractFull ArticleGraphical Abstract
    Keep current with the latest in immune regulation research.
    REVIEWS

    First-Line Immunotherapy for Non–Small-Cell Lung Cancer

    The authors report the current status of first-line immunotherapy in metastatic non–small cell lung cance together with current challenges in selecting the best immunotherapeutic approach for the individual patient.
    [Journal of Clinical Oncology]

    Abstract

    Advances in NK Cell Production

    Scientists summarize the recent advances in expansion strategies with or without genetic manipulation of NK cells derived from various cellular sources.
    [Cellular & Molecular Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Dren Bio Announces Research Collaboration and License Agreement with Pfizer to Discover and Advance Multiple Therapeutic Antibodies Using its Targeted Myeloid Engager and Phagocytosis Platform for the Treatment of Cancer

    Dren Bio, Inc. announced it has entered into a research collaboration and license agreement with Pfizer, Inc. The strategic collaboration will focus on the discovery and development of therapeutic bispecific antibodies for select oncology targets using Dren Bio’s proprietary Targeted Myeloid Engager and Phagocytosis Platform.
    [Dren Bio, Inc. (BuinessWire, Inc.)]

    Press Release

    Merck’s KEYTRUDA® (Pembrolizumab) Showed Statistically Significant Improvement in Disease-Free Survival Versus Placebo as Adjuvant Treatment for Patients with Stage IB-IIIA Non-Small Cell Lung Cancer Regardless of PD-L1 Expression

    Merck announced that the Phase III KEYNOTE-091 trial investigating KEYTRUDA, Merck’s anti-PD-1 therapy, met one of its dual primary endpoints of disease-free survival for the adjuvant treatment of patients with stage IB-IIIA non-small cell lung cancer following surgical resection regardless of PD-L1 expression.
    [Merck]

    Press Release
    FEATURED EVENT

    Lorne Cancer 2022

    February 10 – 12, 2022
    Lorne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Scientist – CART T Cell Cancer Immunotherapies

    Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    Project Manager – Therapeutic Development Branch

    National Institute of Health – Rockville, Maryland, United States

    Postdoctoral Research Associate – iPSC-Based Technologies for Immunotherapies

    Wisconsin National Primate Research Center – Madison, Wisconsin, United States

    Postdoctoral Fellowship – Breast Cancer Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Research Assistant – Vaccine Development

    Centre for Immunology & Infection Limited – Hong Kong, China

    > See All Jobs

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