 | | Vol. 10.03 – 25 January, 2022 |
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| Human and mouse model bronchoalveolar lavage fluid samples were analyzed for the presence and activity of cathepsin S and its endogenous inhibitors.
[American Journal of Respiratory and Critical Care Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used mass cytometry by time-of-flight, flow cytometry, and T cell receptor immunosequencing to conduct simultaneous single-cell analyses of immune cells in the sentinel lymph nodes of melanoma patients.
[Clinical Cancer Research] |
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| Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.
[International Journal of Biological Macromolecules] |
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| Scientists showed that polymorphonuclear-myeloid-derived suppressor cells were present in high numbers in the polymorphonuclear of patients with primary or metastatic lung tumor.
[Frontiers in Immunology] |
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| Investigators used Oncomine and The Cancer Genome Atlas databases to analyze the transcription and survival effect of N-acetylgalactosaminyltransferase genes (GALNTs) in pan-cancer.
[Journal of Leukocyte Biology] |
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| Pretreated specimens were evaluated by immunohistochemistry for programmed cell death protein 1 and its ligand, densities of tumor infiltrative lymphocytes, as well as c-MYC and Ki-67 expressions.
[Clinical and Translational Oncology] |
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| The authors analyzed the influence of the precursor 25-hydroxyvitamin D3 on the differentiation of human CD4+ T cells applying physiological concentrations in vitro.
[Scandinavian Journal of Immunology] |
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| Researchers assessed the correlation between immune infiltration status, chemotherapeutics sensitivity, immune checkpoint proteins, and the signature.
[Reproductive Sciences] |
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| Scientists propose a five-point checklist for defining resident immune cell types in humans and describe the currently known features of resident immune cells, their mechanisms of development, and their putative functional roles within various human organs.
[Annual Reviews of Immunology] |
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| Emphasis is given to the role that leucine-rich α-2 glycoprotein 1 (LRG1) plays as a vasculopathic factor where it disrupts the cellular interactions normally required for the formation and maintenance of mature vessels, thereby indirectly contributing to the establishment of a highly hypoxic and immunosuppressive microenvironment.
[Journal of Biomedical Science] |
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| The development of biomarkers is important for monitoring the effect of treatment, assessing the patient’s response to immune checkpoint inhibitors, determining adverse reactions, and predicting the direction of disease development.
[Biomedicine & Pharmacotherapy] |
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| Cancer Research UK, Vaccitech plc and the Ludwig Institute for Cancer Research, announced the first patient dosed in the MAGE trial, which is testing a novel immunotherapeutic, VTP-600, in patients with the most common type of lung cancer.
[Ludwing Cancer Research] |
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| OSE Immunotherapeutics SA announced that the Japanese Patent Office has issued the notice of allowance for a new patent covering Tedopi®, a combination of neoepitopes, for use after failure with PD-1 or PD-L1 immune checkpoint inhibitor treatment in HLA-A2 positive cancer patients.
[OSE Immunotherapeutics SA] |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Columbia University – New York, New York, United States |
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| | UK Research and Innovation – Oxfordshire, England, United Kingdom |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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