 | | Vol. 10.07 – 8 February, 2022 |
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| Scientists developed a CRISPR activation and CRISPR interference discovery platform in primary human T cells and performed genome-wide screens for functional regulators of cytokine production in response to stimulation.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By mapping 55 neoantigen-specific T cell receptor clonotypes from 10 metastatic human tumors to their single-cell transcriptomes, investigators identified signatures of CD8+ and CD4+ neoantigen-reactive tumor-infiltrating lymphocytes.
[Science] |
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| Researchers found that distant metastases were more immune inert with increased M2 macrophages compared to their matched primary tumors.
[Science Translational Medicine] |
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| Investigators studied the live lung longitudinally and follow the fate of individual disseminated tumor cells that spontaneously disseminated from orthotopic breast tumors.
[Nature Communications] |
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| Using single-cell sequencing, scientists showed that tumor-induced lymphocytes include skewed T cell clonotypes, which were characterized by exhaustion or nonexhaustion signatures.
[Cell Reports] |
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| Researchers investigated the effect of different initial rituximab (RTX) regimens on B cell depletion. This single-center retrospective analysis included children with autoimmune neurological diseases who received RTX.
[Multiple Sclerosis Journal] |
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| Scientists evaluated the effects of the specialized pro-resolving mediators lipids, lipoxin A4 and lipoxin B4, on neutrophils isolated from patients with atherosclerosis compared with healthy controls.
[FASEB Journal] |
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| The authors demonstrated abnormalities of neutrophil function, namely neutrophil extracellular trap formation in splenectomised and non-splenectomised β-thalassaemia/HbE patients who had iron overload.
[Scientific Reports] |
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| Researchers showed that myeloid cells from cord blood could be activated to express T cell costimulatory markers, and also to produced Th1 promoting cytokines.
[Journal of Leukocyte Biology] |
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| Scientists investigated the effects of sulfated deoxycholic acid, sulfated lithocholic acid, and their unsulfated forms on intestinal barrier function and immune response..
[Heliyon] |
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| Investigators describe the function of the aryl hydrocarbon receptor in different immune cells, and connect with their roles in cancer immunology.
[Trends in Immunology] |
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| Orange Grove Bio and SV Investment announced the establishment of a new partnership through which the companies will collaborate on jointly sourcing and developing novel therapeutics in the United States and Korea.
[Orange Grove Bio (Globe Newswire, Inc.)] |
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| Actuate Therapeutics, Inc. announced the opening of a randomized study of elraglusib plus FOLFIRINOX alone or with Losartan for patients with advanced pancreatic cancer in the first-line setting.
[Actuate Therapeutics, Inc. (Globe Newswire, Inc.)] |
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| March 9 – 12, 2022
Munich, Germany |
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| | Imperial College London – London, England, United Kingdom |
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| | King’s College London- London, England, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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| | Ragon Institute – Boston, Massachusetts, United States |
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