Human Immunology News Volume 10.06 | Feb 15 2022

May 12, 2022

2022-02-15 | HIN 10.08

Human Immunology News by STEMCELL Technologies

Vol. 10.08 – 15 February, 2022

TOP STORY

Tryptophan-Derived Microbial Metabolites Activate the Aryl Hydrocarbon Receptor in Tumor-Associated Macrophages to Suppress Anti-Tumor Immunity

Researchers examined the impact of aryl hydrocarbon receptor in tumor-associated macrophage function in pancreatic ductal adenocarcinoma.
[Immunity]

Abstract Graphical Abstract Press Release

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Cancer-Cell-Derived GABA Promotes β-Catenin-Mediated Tumor Growth and Immunosuppression

The authors reported that cancer cells with aberrant expression of glutamate decarboxylase 1 rewired glutamine metabolism for the synthesis of γ-aminobutyric acid (GABA)—a prominent neurotransmitter—in non-nervous tissues.
[Nature Cell Biology]

Abstract

Surface Ig Variable Domain Glycosylation Affects Autoantigen Binding and Acts as Threshold for Human Autoreactive B Cell Activation

Combining crystallography, glycobiology, and functional B cell assays allowed researchers to dissect key characteristics of variable domain glycans on human B cell biology.
[Science Advances]

Full Article

Single-Cell Analysis of Human Glioma and Immune Cells Identifies S100A4 as an Immunotherapy Target

Investigators reported an integrated analysis of 201,986 human glioma, immune, and other stromal cells at the single cell level.
[Nature Communications]

Full Article Full Article

Single-Cell RNA Sequencing Reveals Induction of Distinct Trained Immunity Programs in Human Monocytes

Researchers demonstrated cellular transcriptional programs to four different inducers of trained immunity in monocyte populations at single-cell resolution.
[Journal of Clinical Investigation]

Abstract

SENP7 Senses Oxidative Stress to Sustain Metabolic Fitness and Antitumor Functions of CD8⁺ T Cells

Investigators reported that SUMO-specific protease 7 (SENP7) sensed oxidative stress to maintain the CD8⁺ T cell metabolic state and antitumor functions.
[Journal of Clinical Investigation]

Abstract Full Article Graphical Abstract

Single-Cell Isoform Analysis in Human Immune Cells

The authors used R2C2 to sequence and demultiplex 12 million full-length cDNA molecules generated by the 10X Genomics platform from ~3000 peripheral blood mononuclear cells.
[Genome Biology]

Full Article

CCR8-Targeted Specific Depletion of Clonally Expanded Treg Cells in Tumor Tissues Evokes Potent Tumor Immunity with Long-Lasting Memory

Scientists found that multiclonal Tregs presented in tumor tissues predominantly expressed the chemokine receptor CCR8.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Activation and Expansion of T-Follicular Helper Cells in Chronic Lymphocytic Leukemia Nurselike Cell Co-Cultures

In co-cultures from 28 different chronic lymphocytic leukemia patients, the authors detected an expansion of T-follicular helper cells based on PD-1, BCL6, and ICOS expression, with increased IL-21 and downmodulated CD40L surface expression.
[Leukemia]

Abstract

RFX Transcription Factors Control a miR-150/PDAP1 Axis That Restrains the Proliferation of Human T Cells

Researchers found that in primary human memory T helper lymphocytes, miR-150 was the most abundantly expressed miRNA, and its expression decreased drastically upon activation, suggesting regulatory roles.
[PLoS Biology]

Full Article

Differential Localization and Limited Cytotoxic Potential of Duodenal CD8⁺ T Cells

Scientists examined the spatial localization, phenotype, and function of CD8⁺ T cells in the human duodenal tissue from people living with HIV and healthy controls.
[JCI Insight]

Full Article Graphical Abstract

A New k_Ca3.1 Channel Activator SKA-346 Boosts T Cell Antitumor Response in the Immune Suppressive Microenvironment

The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K⁺]_e intracellularly.
[Biophysical Journal]

Abstract

REVIEWS

Control of Immunity via Nutritional Interventions

Scientists discuss recent evidence and emerging concepts supporting the idea that our newfound relationship with nutrition in industrialized countries has fundamentally altered the way in which our immune system is wired.
[Immunity]

Full Article

INDUSTRY AND POLICY NEWS

Intellia and ONK Therapeutics Announce Collaboration to Advance Allogeneic CRISPR-Edited NK Cell Therapies for the Treatment of Patients with Cancer

Intellia Therapeutics, Inc., a company focused on developing curative therapies leveraging CRISPR-based technologies, and ONK Therapeutics Ltd., a company dedicated to developing optimally engineered NK cell therapies to treat cancer, announced a licensing and collaboration agreement.
[Intellia Therapeutics, Inc.]

Press Release

Active Biotech Enters into Global Patent License Agreement with Oncode Institute for Tasquinimod in Myelofibrosis

Active Biotech announced it has entered into an exclusive license agreement with Oncode Institute in the Netherlands, for the global rights to patents relating to the use of tasquinimod and other inhibitors of S100 for use in treatment of myelofibrosis.
[Active Biotech]

Press Release

PDS Biotech Announces Clinical Trial with Mayo Clinic to Study PDS0101 in Early Stage Pre-Metastatic- HPV-Associated Head and Neck Cancer

PDS Biotechnology Corporation announced the initiation of an Investigator-Initiated Trial, MC200710, for PDS0101 alone or in combination with the checkpoint inhibitor, KEYTRUDA^®, in patients with HPV-associated oropharyngeal cancer at high risk of recurrence.
[PDS Biotechnology Corporation]

Press Release

FEATURED EVENT

Tryptophan-Derived Microbial Metabolites Activate the Aryl Hydrocarbon Receptor in Tumor-Associated Macrophages to Suppress Anti-Tumor Immunity

Cancer-Cell-Derived GABA Promotes β-Catenin-Mediated Tumor Growth and Immunosuppression

Surface Ig Variable Domain Glycosylation Affects Autoantigen Binding and Acts as Threshold for Human Autoreactive B Cell Activation

Single-Cell Analysis of Human Glioma and Immune Cells Identifies S100A4 as an Immunotherapy Target

Single-Cell RNA Sequencing Reveals Induction of Distinct Trained Immunity Programs in Human Monocytes

SENP7 Senses Oxidative Stress to Sustain Metabolic Fitness and Antitumor Functions of CD8⁺ T Cells

Single-Cell Isoform Analysis in Human Immune Cells

CCR8-Targeted Specific Depletion of Clonally Expanded Treg Cells in Tumor Tissues Evokes Potent Tumor Immunity with Long-Lasting Memory

Activation and Expansion of T-Follicular Helper Cells in Chronic Lymphocytic Leukemia Nurselike Cell Co-Cultures

RFX Transcription Factors Control a miR-150/PDAP1 Axis That Restrains the Proliferation of Human T Cells

Differential Localization and Limited Cytotoxic Potential of Duodenal CD8⁺ T Cells

A New k_Ca3.1 Channel Activator SKA-346 Boosts T Cell Antitumor Response in the Immune Suppressive Microenvironment

Control of Immunity via Nutritional Interventions

Intellia and ONK Therapeutics Announce Collaboration to Advance Allogeneic CRISPR-Edited NK Cell Therapies for the Treatment of Patients with Cancer

Active Biotech Enters into Global Patent License Agreement with Oncode Institute for Tasquinimod in Myelofibrosis

PDS Biotech Announces Clinical Trial with Mayo Clinic to Study PDS0101 in Early Stage Pre-Metastatic- HPV-Associated Head and Neck Cancer

Cell Symposium: Viruses in Health and Disease

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Research Associate – B Cells Immunity cSCC

Postdoctoral Scientist – Cellular Immunology/T Cell Therapy

Research Scientist – T Cell Stimulation

Research Association – Myeloma Cancer Cells

Research Associate – Molecular Biologist

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