Human Immunology News Volume 10.07 | Feb 22 2022

    By
    Justin.choi
    -
    0
    39







    2022-02-09 | HIN 10.07


    Human Immunology News by STEMCELL Technologies
    Vol. 10.07 – 22 February, 2022
    TOP STORY

    PD-L1 Blockade Liberates Intrinsic Antitumourigenic Properties of Glycolytic Macrophages in Hepatocellular Carcinoma

    Scientists elucidated the nature, regulation and functional relevance of PD-L1+ host cells in HCC.
    [Gut]

    Abstract
    Explore virtual support and resources to stay productive and connected with your field.
    PUBLICATIONSRanked by the impact factor of the journal

    A FBXO7/EYA2-SCFFBXW7 Axis Promotes AXL-Mediated Maintenance of Mesenchymal and Immune Evasion Phenotypes of Cancer Cells

    Researchers identified FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells.
    [Molecular Cell]

    Abstract

    Hypoxia-Driven Immunosuppression by Treg and Type-2 Conventional Dendritic Cells in Hepatocellular Carcinoma

    Investigators analyzed the immune landscapes of hypoxia-low and -high tumor regions using cytometry by time-of-flight, immunohistochemistry and transcriptomic analyses.
    [Hepatology]

    Abstract

    Estrogen-Mediated Downregulation of HIF-1α Signaling in B Lymphocytes Influences Postmenopausal Bone Loss

    Using genetically modified mice and high-throughput analyses, scientists demonstrated that prolonged HIF-1α signaling in B cells led to enhanced RANKL production and osteoclast formation.
    [Bone Research]

    Full Article

    T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages

    Using a human in vitro tri-culture system of macrophages with activated autologous T cells and BRAFV600E mutant melanoma cells, researchers showed that activated T cells and the synthetic triterpenoid the methyl CDDO-Me attenuated immune suppression.
    [Frontiers in Immunology]

    Full Article

    Adaptive NK Cells Undergo a Dynamic Modulation in Response to Human Cytomegalovirus and Recruit T Cells in In Vitro Migration Assays

    Investigators studied the relationship between human cytomegalovirus reactivation and adaptive NK cells in 70 patients monitored weekly until day +100 after hematopoietic stem cell transplantation
    [Bone Marrow Transplantation]

    Full Article

    Impaired TRPM3-Dependent Calcium Influx and Restoration Using Naltrexone in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

    Live cell immunofluorescent imaging was used to measure TRPM3-dependent Ca2+ influx in NK cells isolated from ten myalgic encephalomyelitis/chronic fatigue syndrome patients and ten age- and sex-matched healthy controls following modulation with TRPM3-agonist, pregnenolone sulfate and TRPM3-antaognist, ononetin.
    [Journal of Translational Medicine]

    Full Article

    Tollip Interaction with STAT3: A Novel Mechanism to Regulate Human Airway Epithelial Responses to Type 2 Cytokines

    Toll-interacting protein (Tollip) deficient primary human airway epithelial cells from four healthy donors were generated by the gene knockdown approach and stimulated with IL-13 to measure activation of transcription factor STAT3, and eotaxin-3, an eosinophilic chemokine.
    [Respiratory Research]

    Full Article

    Neutrophil-Derived Extracellular Vesicles Promote Feed-Forward Inflammasome Signaling in Cystic Fibrosis Airways

    Researchers hypothesized that cystic fibrosis airway neutrophils contribute to chronic inflammation, in part, via the packaging of inflammasome-inducing signals in extracellular vesicles.
    [Journal of Leukocyte Biology]

    Abstract

    Combined Tumor and Immune Signals from Genomes or Transcriptomes Predict Outcomes of Checkpoint Inhibition in Melanoma

    The authors analyzed whole-exome and bulk RNA sequencing of tumors from new and published cohorts of 189 and 178 patients with melanoma receiving checkpoint blockade, respectively.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Circadian Regulation of Innate Immunity in Animals and Humans and Implications for Human Disease

    Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude of the inflammatory response to the numbers of circulating immune cells varying throughout the day.
    [Seminars in Immunopathology]

    Full Article

    Human Microbial Dysbiosis as Driver of Gynecological Malignancies

    Emerging evidence suggests that several microbial signatures are significantly associated with gynecological cancers.
    [Biochimie]

    Abstract
    INDUSTRY AND POLICY NEWS

    ImmunoScape Inks Licensing Deal with Pure MHC to Advance Development of Novel TCR-Based Therapies

    ImmunoScape announced that it has signed a licensing deal with Pure MHC, LLC, a target discovery and development company, to pursue TCR-T therapeutics against Pure MHC-identified antigens in lung cancer, colorectal cancer, and other cancer indications.
    [ImmunoScape]

    Press Release

    Zai Lab Announces Breakthrough Therapy Designation Granted for Repotrectinib in China

    Zai Lab Limited announced that the Center for Drug Evaluation of the National Medical Products Administration granted Breakthrough Therapy Designation for investigational repotrectinib for the treatment of patients with ROS1-positive metastatic non-small cell lung cancer.
    [Zai Lab Limited]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting

    April 7 – April 9
    Rome, Italy & Virtual

    > See All Events

    JOB OPPORTUNITIES

    Senior Scientist – Inflammatory and Autoimmune Disorders

    Genetech – South San Francisco, California, United States of America

    Postdoctoral Position – Tissue Engineering and Epigenetics

    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Associate – Cell Viability

    Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore

    Research Associate – B Cells Immunity cSCC

    Imperial College London – London, England, United Kingdom

    Postdoctoral Scientist – Cellular Immunology/T Cell Therapy

    TU Dresden – Dresden, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter