Human Immunology News Volume 10.11 | Mar 22 2022

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    2022-03-22 | HIN 10.11


    Human Immunology News by STEMCELL Technologies
    Vol. 10.11 – 22 March, 2022
    TOP STORY

    Extracellular Matrix Proteins Regulate NK Cell Function in Peripheral Tissues

    Extracellular matrix proteins, collagen I, collagen III, and elastin, blocked NK cell cytotoxicity and promoted their chemokine/cytokine production. NK cell cytotoxicity against major histocompatibility complex class I–deficient melanoma in the skin was markedly increased by blocking tumor collagen deposition.
    [Science Advances]

    Full ArticlePress Release
    Virtual Conference Exhibition: Immunology
    PUBLICATIONSRanked by the impact factor of the journal

    Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma

    Tumor and blood samples were analyzed by flow cytometry, immunohistochemistry, transcriptome and cytokine profiling. Cabozantinib-related effects were validated in a colorectal cancer PDX model.
    [Clinical Cancer Research]

    Abstract

    AhR Promotes Phosphorylation of ARNT Isoform 1 in Human T Cell Malignancies as a Switch for Optimal AhR Activity

    Investigators demonstrated that proportional flux in the levels of aryl hydrocarbon receptor (AhR) nuclear translocator isoforms 1 and 3 modulated ARNT signaling in terms of amplitude and expression of distinct gene programs.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    sEH-Derived Metabolites of Linoleic Acid Drive Pathologic Inflammation While Impairing Key Innate Immune Cell Function in Burn Injury

    12,13-dihydroxyoctadecenoic acid was found to facilitate the maturation and activation of stimulated neutrophils, while impeding monocyte and macrophage functionality and cytokine generation.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Nodal Cytotoxic Peripheral T Cell Lymphoma Occurs Frequently in the Clinical Setting of Immunodysregulation and Is Associated with Recurrent Epigenetic Alterations

    Ten patients had a history of B cell malignancies, one each of myeloid neoplasm, breast or prostate cancer, and four others had underlying immune disorders. Most patients died, mostly of disease, with a median overall survival of 12.7 months.
    [Modern Pathology]

    Abstract

    Immuno-Colocalization of IRF5 with TRAF6 and AKT2 in Human Apical Periodontitis

    Researchers explored the expression and colocalization of interferon regulatory factor 5 (IRF5) with tumor necrosis factor receptor-associated factor 6 (TRAF6) and AKT2 in human apical periodontitis.
    [Journal of Endodontics]

    Abstract

    Peripheral Blood Mononuclear Cell Gene Expression and Cytokine Profiling in Patients with Intermittent Claudication Who Exhibit Exercise Induced Acute Renal Injury

    Scientists conducted a single center observational cohort study of patients diagnosed with intermittent claudication. Blood and urine samples were collected at rest and following a standardized treadmill exercise protocol.
    [PLoS One]

    Full Article

    A Three-Dimensional Immune-Oncology Model for Studying In Vitro Primary Human NK Cell Cytotoxic Activity

    The authors described a simple and effective protocol to study the cytotoxic activity of primary human NK cells toward the 3D tumor spheroids.
    [PLoS One]

    Full Article

    AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC through Expansion of TCF1+ CD8 T Cells

    Investigators demonstrated that AXL was a critical targetable driver of immune suppression in STK11/LKB1 mutant non-small cell lung cancer NSCLC.
    [Cell Reports Medicine]

    Full ArticlePress ReleaseGraphical Abstract
    Cell Preparation For Crossmatch Assays
    REVIEWS

    Transforming Growth Factor–β1 in Regulatory T Cell Biology

    The authors review transforming growth factor–β1 (TGF-β1) signaling in T regulatory cell (Treg) development and function and discuss knowledge gaps, future research, and the TGF-β1/Treg axis in the context of cancer immunotherapy and fibrosis.
    [Science Immunology]

    Full Article

    Checkpoint Inhibitor/Interleukin-Based Combination Therapy of Cancer

    Scientists discuss the possibility of using interleukins (ILs) and IL-targeting drugs in combination with immune checkpoint inhibitors in cancer immunotherapy and describing recent advances in the field using PEGylated ILs and fusion proteins.
    [Cancer Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Immutep Announces Second Japanese Patent Grant for LAG-3 Antagonist Antibody LAG525

    Immutep Limited announced the grant of patent No. 7030750 entitled “Antibody molecules to LAG-3 and uses thereof” by the Japanese Patent Office directed to pharmaceutical compositions for use in the treatment of cancer.
    [Immutep Limited]

    Press Release

    US Food and Drug Administration Approves First LAG-3-Blocking Antibody Combination, Opdualag™ (Nivolumab and Relatlimab-rmbw), as Treatment for Patients with Unresectable or Metastatic Melanoma

    Bristol Myers Squibb announced that OpdualagTM was approved by the FDA for the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma.
    [Bristol Myers Squibb]

    Press Release
    FEATURED EVENT

    13th Online Dutch Stem Cell Meeting

    April 16, 2022
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – CAR-T Cell Exhaustion in Solid Tumors

    Seattle, Washington, United States – Fred Hutchinson Cancer Research Center

    Staff Scientist – Human Pluripotent Stem Cells

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Senior Associate Scientist – Biology

    Gilead Sciences – Foster City, California, United States

    Research Chair – Canada Excellence

    University of Sherbrooke – Sherbrooke, Quebec, Canada

    Postdoctoral Scientist – Liver Resident Memory T Cell

    Amsterdam UMC – Amsterdam, Netherlands

    > See All Jobs

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