Human Immunology News Volume 10.12 | Mar 29 2022

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    2022-03-29 | HIN 10.11


    Human Immunology News by STEMCELL Technologies
    Vol. 10.12 – 29 March, 2022
    TOP STORY

    Tissue-Resident FOLR2+ Macrophages Associate with CD8+ T Cell Infiltration in Human Breast Cancer

    Researchers identified a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors.
    [Cell]

    AbstractGraphical Abstract
    SepMateâ„¢ PBMC Isolation
    PUBLICATIONSRanked by the impact factor of the journal

    HLA Autoimmune Risk Alleles Restrict the Hypervariable Region of T Cell Receptors

    The authors investigated the influence of human leukocyte antigen (HLA) alleles on T cell receptor composition at the highly diverse complementarity determining region 3, which conferred antigen recognition.
    [Nature Genetics]

    Abstract

    Radiotherapy Orchestrates Natural Killer Cell Dependent Antitumor Immune Responses through CXCL8

    Using a reverse translational approach, investigators showed a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8–dependent mechanism.
    [Science Advances]

    Full Article

    Targeting Myeloid Derived Suppressor Cells Reverts Immune Suppression and Sensitizes BRAF-Mutant Papillary Thyroid Cancer to MAPK Inhibitors

    Scientists demonstrated that BRAFV600E promoted thyroid cancer development by increasing myeloid-derived suppressor cells penetrance.
    [Nature Communications]

    Full Article

    Human Induced-T-to-Natural Killer Cells Have Potent Anti-Tumor Activities

    Inactivation of BCL11B were performed by CRISPR/Cas9 in human T cells. Immunophenotypic and transcriptional profiles of sgBCL11B T cells were characterized by cytometer and transcriptomics, respectively.
    [Biomarker Research]

    Full Article

    GRK2 Selectively Attenuates the Neutrophil NADPH-Oxidase Response Triggered by β-Arrestin Recruiting GPR84 Agonists

    Researchers investigated the effects of GRK2 inhibitors on neutrophil functions induced by GPR84 and FPR2 agonists. GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a cytosolic localization.
    [Biochimica Et Biophysica Acta-Molecular Cell Research]

    Full Article

    Pharmacodynamic Modeling and Exposure-Response Assessment of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders

    A hematopoietic transit model was developed to describe the joint effects of reducing influx from pro-B cells and accelerating CD20+ B cell depletion in the blood by inebilizumab.
    [British Journal of Clinical Pharmacology]

    AbstractFull Article

    Characterization of the Immune Cell Infiltration Landscape in Lung Adenocarcinoma

    Scientists proposed a new and more effective immunophenotyping method for evaluating the prognosis and tumor microenvironment cellular infiltration characteristics in lung adenocarcinoma patients and their response to immunotherapy.
    [Archives of Biochemistry and Biophysics]

    Full Article
    The StemSpanâ„¢ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Engineering the T Cell Receptor for Fun and Profit: Uncovering Complex Biology, Interrogating the Immune System, and Targeting Disease

    The authors review T cell receptors (TCR) engineering, starting with a brief historical overview followed by discussions of more recent developments, including new efforts and opportunities to engineer TCR affinity, modulate specificity, and develop novel TCR-based constructs.
    [Current Opinion in Structural Biology]

    Abstract

    Regulation of the Antigen Presentation Machinery in Cancer and Its Implication for Immune Surveillance

    Investigators provide a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression.
    [Biochemical Society Transactions]

    Full Article

    Human Peripheral Blood Mononuclear Cells: A Review of Recent Proteomic Applications

    The study of molecular content of peripheral blood mononuclear cells can provide better understanding of immune processes giving the possibility of monitoring the health conditions of the host organism.
    [Proteomics]

    Abstract
    INDUSTRY AND POLICY NEWS

    Sangamo Therapeutics Announces Dosing of First Patient in Phase I/II Clinical Study of Investigational CAR-Treg Cell Therapy TX200 in Kidney Transplantation

    Sangamo Therapeutics, Inc. announced dosing of the first patient in the Phase I/II STEADFAST clinical study evaluating TX200, a wholly-owned autologous CAR-Treg cell therapy product candidate for the prevention of immune-mediated rejection in HLA-A2 mismatched kidney transplantation from a living donor.
    [Sangamo Therapeutics, Inc.]

    Press Release

    UroGen Announces FDA Clearance of IND Application for the Investigational Immunotherapy UGN-301 (zalifrelimab) Intravesical Solution in Recurrent Non-Muscle Invasive Bladder Cancer

    UroGen Pharma Ltd. announced that the FDA has cleared UroGen’s Investigational New Drug (IND) application to begin a novel Phase I clinical study of the anti-CTLA-4 immunotherapy UGN-301 in patients with recurrent non-muscle invasive bladder cancer.
    [UroGen Pharma Ltd. ]

    Press Release
    FEATURED EVENT

    SPI Portuguese Society for Immunology Annual Meeting

    April 20 – 22, 2022
    Lisbon, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow Position – Translational Research

    Stanford University – Stanford, California, United States

    Postdoctoral Research Associate – Intestinal Epithelial Barrier

    Princeton University – Princeton, New Jersey, United States

    Postdoctoral Scientist – Intestinal Immune Homeostasis

    Columbia University – New York, New York, United States

    Postdoctoral Fellow – CAR-T Cell Exhaustion in Solid Tumors

    Fred Hutchinson Cancer Research Center -Seattle, Washington, United States

    Staff Scientist – Human Pluripotent Stem Cells

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    > See All Jobs

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