 | | Vol. 10.13 – 5 April, 2022 |
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| By testing immunogenicity with autologous blood lymphocytes from patients with cancer, scientists detected pre-established CD4+ and CD8+ T cell responses for 10 of 21 and for 1 of 30 previously identified gene fusions, respectively.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Via an unbiased genome-wide CRISPR/Cas9 screening, the authors identified loss of NOXA, a B cell lymphoma 2 family protein in B cell malignancies, as a pivotal regulator of resistance to chimeric antigen receptor (CAR) T cell therapy by impairing apoptosis of tumor cells both in vitro and in vivo.
[Signal Transduction and Targeted Therapy] |
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| Researchers performed the largest transcriptome-wide association study for postpartum depression to date using RNA-sequencing in whole blood and deconvoluted cell types.
[Molecular Psychiatry] |
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| Investigators systematically dissected pancreatic ductal adenocarcinoma intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identified Vps4b and Rnf31 as essential factors required for escaping CD8+ T cell killing.
[Nature Communications] |
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| Scientists examined tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma using a computational model, ecological analysis of digital pathology data, and neoantigen prediction in 62 patient samples.
[Nature Communications] |
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| The authors observed increased plasma and platelet surface expressed high mobility group box 1 (HMGB1) in stroke patients. Mechanistically, platelets were identified as the critical source for HMGB1 causing neutrophil extracellular traps in the acute phase of stroke.
[Journal of Clinical Investigation] |
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| Researchers explored the role of miRNAs in the pathogenesis of inflammatory bowel disease (IBD) and identified reduced expression of miR-374a-5p in IBD monocytes that correlated with a module of up-regulated genes related to the inflammatory response.
[Journal of Experimental Medicine] |
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| The authors demonstrated that homology cluster analysis of T cell receptor (TCR) repertoires efficiently identified tumor-reactive TCRs.
[eLife] |
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| Scientists showed that IL-22+ T cells coexpressing retinoic acid–related orphan receptor γt were enriched at the human maternal-fetal interface of women with preterm labor and birth, which was confirmed by in silico analysis of single-cell RNA sequencing data.
[Journal of Immunology] |
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| Investigators conducted a prospective single-center Phase II trial in which they added autologous anti-CD19 humanized binding domain T cells to ibrutinib in chronic lymphocytic leukemia patients not in complete remission despite at least six months of ibrutinib.
[Blood Advances] |
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| The authors investigated the features of CCR8+ regulatory T cells (Tregs) in lung cancer patients. CCR8+ Tregs were highly activated and infiltration of CCR8+ Tregs in tumors was associated with poor prognosis in lung cancer patients.
[Scientific Reports] |
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| Researchers characterized the distribution of tumor-infiltrating lymphocytes and tertiary lymphoid structures using CD3, CD4, CD8, CD20 immunohistochemistry in a cohort of 10 eccrine porocarcinomas and 49 of their benign counterpart, poroma.
[Scientific Reports] |
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| The authors presented the PROSECO prospective observational study on 457 patients with lymphoma that received two or three COVID-19 vaccine doses and showed undetectable humoral responses following two vaccine doses in 52% of patients undergoing active anticancer treatment.
[Nature Cancer] |
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| Scientists examine the diversity of tumor-associated macrophages (TAMs) in various cancer indications and how this heterogeneity is being revisited with the advent of single-cell technologies and explore the current knowledge on the functional roles of different TAM states.
[Nature Reviews Clinical Oncology] |
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| Investigators review the phenotypic heterogeneity of intratumoral B cells and the importance of tertiary lymphoid structures (TLS) in their generation as well as the potential of B cells and TLS as prognostic and predictive biomarkers.
[Nature Reviews Clinical Oncology] |
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| The authors review both antitumor and tolerogenic dendritic cell (DC) responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs.
[Science Immunology] |
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| Genprex, Inc. announced the opening for patient enrollment of its Acclaim-2 clinical trial, a Phase I/II clinical trial evaluating the company’s lead drug candidate, REQORSA™ Immunogene Therapy, in combination with Keytruda® in patients with late-stage non-small cell lung cancer.
[Genprex, Inc.] |
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| The FDA approved axicabtagene ciloleucel for adult patients with large B cell lymphoma that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy.
[US FDA] |
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| May 4 – 5, 2022
San Francisco, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Kentucky – Lexington, Kentucky, United States |
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| | The Wellcome Trust – London, England, United Kingdom |
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