 | | Vol. 10.14 – 12 April, 2022 |
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| Researchers developed a framework for the classification of individual cells, and by combining single-cell RNA sequencing data with genotype data, they mapped the genetic effects on gene expression in each of 14 immune cell types and identified 26,597 independent cis–expression quantitative trait loci (eQTLs).
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed an alternative strategy to isolate T cell receptor mutants that exhibited high activation signals coupled with low-affinity peptide-major histocompatibility complex binding through the acquisition of catch bonds.
[Science] |
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| The authors described a genetically engineered cell membrane nanovesicle that integrated antigen self-presentation and immunosuppression reversal for cancer immunotherapy.
[Nature Nanotechnology] |
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| By analyzing a large number of T cells at the single-cell level on a microwell array, scientists showed that T cell activation could occur via cis interactions, and that such cis activation could be used to detect antigen-specific T cells and clone their T cell receptor within four days.
[Nature Biomedical Engineering] |
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| Investigators characterized blood samples collected from 51 preterm infants, 20 healthy term infants at birth and age 3 to 16 weeks, and five healthy adults, and observed strong associations between type 2 immune polarization in circulating CD3+CD4+ T cells and cardiopulmonary illness, with odds ratios up to 24.
[Science Translational Medicine] |
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| The authors combined genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulated IRF8 expression and demonstrated that the locus containing rs2280381 was a cell-type-specific enhancer for IRF8 that spatially interacted with the IRF8 promoter.
[Nature Communications] |
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| Researchers showed the citrullination of pancreatic glucokinase as a result of inflammation, triggering autoimmunity and affecting glucokinase biological functions.
[Nature Communications] |
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| Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.
[Journal of Experimental Medicine] |
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| The authors used carbon monoxide, a short-lived gaseous molecule, to test if engaging moderate endoplasmic reticulum stress conditions could improve mitochondrial and anti-tumor functions in T cells.
[Cancer Research] |
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| Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.
[Cell Reports] |
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| Scientists suggested that inflammatory mediators in synovial fluid, including TNF-α, recruited sodium bicarbonate cotransporter n1 (NBCn1) to the plasma membrane of fibroblast-like synoviocytes to provide dynamic properties and that modulation of NBCn1 could be developed into a therapeutic strategy for rheumatoid arthritis.
[Experimental & Molecular Medicine] |
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| The authors compared surface receptor expression and cytokine production between peripheral blood NK cells from 90 type 2 diabetes mellitus patients and 62 age- and sex-matched healthy controls.
[Frontiers in Immunology] |
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| Researchers examined the role of vitamin D deficiency in the regulation of cathelicidin antimicrobial peptide in Crohn’s disease (CD)-like macrophages, including those infected with Mycobacterium avium subsp. paratuberculosis isolated from CD patients.
[Frontiers in Cellular and infection Microbiology] |
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| The authors review the current understanding of the genetics of autoimmune Addison disease and its position in the wider field of autoimmune disorders and discuss the mechanisms that could underlie the effects on the adrenal cortex.
[Nature Reviews Endocrinology] |
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| Investigators discuss what is known about the effects of various immunotherapies on immunological responses to vaccines and what these effects mean for the safe and effective use of vaccines in patients with a neuroimmunological disease.
[Nature Reviews Neurology] |
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| Scientists summarize the intrinsic mechanisms of oncolytic viruses (OVs), describe the optimization strategies for using armed OVs to enhance the effects of antitumor immunity, and highlight rational combinations of OVs with other immunotherapies in recent preclinical and clinical studies.
[Signal Transduction and Targeted Therapy] |
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| IO Biotech, a clinical-stage biopharmaceutical company developing immune-modulating cancer therapies based on its T-win® technology platform, announced that it has dosed the first patient, in metastatic non-small cell lung cancer, in its Phase II IOB-022 / KN-D38 trial.
[IO Biotech] |
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| The WHO Strategic Advisory Group of Experts on Immunization concluded that a single-dose HPV vaccine delivers solid protection against HPV, the virus that causes cervical cancer, that is comparable to two-dose schedules.
[World Health Organization] |
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| May 11 – 15, 2022
Amsterdam, Netherlands |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of California San Francisco – San Francisco, California, United States |
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