Human Immunology News Volume 10.15 | Apr 19 2022

    By
    Justin.choi
    -
    0
    73







    2022-04-19 | HIN 10.15


    Human Immunology News by STEMCELL Technologies
    Vol. 10.15 – 19 April, 2022
    TOP STORY

    Single-Cell RNA-Seq Reveals Cell Type-Specific Molecular and Genetic Associations to Lupus

    Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.
    [Science]

    AbstractGraphical Abstract
    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    Interferon-A Potentiates Anti-PD-1 Efficacy by Remodeling Glucose Metabolism in the Hepatocellular Carcinoma Microenvironment

    Scientists found that a combination of interferon alpha and anti-PD-1-based immunotherapy resulted in enhanced antitumor activity in unresectable hepatocellular carcinoma patients.
    [Cancer Discovery]

    Full Article

    Ovarian Cancer Immunogenicity Is Governed by a Narrow Subset of Progenitor Tissue-Resident Memory T Cells

    The authors reported that the hallmarks of tumor recognition in ovarian cancer-infiltrating T cells were primarily restricted to tissue-resident memory cells.
    [Cancer Cell]

    Full ArticlePress ReleaseGraphical Abstract

    Autologous Regulatory T Cell Transfer in Refractory Ulcerative Colitis with Concomitant Primary Sclerosing Cholangitis

    Investigators reported on the successful adoptive transfer of autologous, ex vivo expanded regulatory T cells in a patient with refractory ulcerative colitis and associated primary sclerosing cholangitis, for which effective therapy is currently not available.
    [Gut]

    Full Article

    Tissue-Resident Memory CD8+ T Cells Cooperate with CD4+ T Cells to Drive Compartmentalized Immunopathology in the CNS

    Researchers investigated whether resting CD8+ memory T cells persisting after cleared infection with attenuated lymphocytic choriomeningitis virus could initiate immune responses directed against cognate self-antigen in the central nervous system.
    [Science Translational Medicine]

    Abstract

    C-Myc-Driven Glycolysis Polarizes Functional Regulatory B Cells That Trigger Pathogenic Inflammatory Responses

    The authors demonstrated that, although IL-10 itself is anti-inflammatory, IL-10+ functional regulatory B cells in patients with systemic lupus erythematosus displayed aggressive inflammatory features.
    [Signal Transduction and Targeted Therapy]

    Full Article

    CD45RA+CD62L– ILCs in Human Tissues Represent a Quiescent Local Reservoir for the Generation of Differentiated ILCs

    Scientists suggested distinct differentiation potential of CD62L+ and CD62L– innate lymphoid cells (ILCs) between tissue microenvironments and identified that manipulation of these cells was a possible approach to restore tissue-immune homeostasis.
    [Science Immunology]

    AbstractPress Release

    Classification of Human Chronic Inflammatory Skin Disease Based on Single-Cell Immune Profiling

    Investigators single-cell–profiled CD45+ immune cell transcriptomes from skin samples of 31 patients and revealed active proliferative expansion of regulatory T and tissue-resident memory T cells components and universal T cell exhaustion in human rashes, with a relative attenuation of antigen-presenting cells.
    [Science Immunology]

    Abstract

    The Tumor Suppressor Adenomatous Polyposis Coli Regulates T Lymphocyte Migration

    The authors addressed whether adenomatous polyposis coli (APC) played a role in T lymphocyte migration. Using a series of cell biology tools, they unveiled that T cells from familial adenomatous polyposis patients carrying APC mutations displayed impaired adhesion and motility in constrained environments.
    [Science Advances]

    Full ArticlePress Release

    Single-Cell RNA Sequencing Coupled to TCR Profiling of Large Granular Lymphocyte Leukemia T Cells

    Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.
    [Nature Communications]

    Full Article

    Neoantigen-Specific CD8 T Cell Responses in the Peripheral Blood Following PD-L1 Blockade Might Predict Therapy Outcome in Metastatic Urothelial Carcinoma

    The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.
    [Nature Communications]

    Full Article

    PD-L1 and ICOSL Discriminate Human Secretory and Helper Dendritic Cells in Cancer, Allergy and Autoimmunity

    Researchers showed, by using 16 different stimuli in vitro, that activated dendritic cells in human blood were phenotypically and functionally dichotomous, and pure cultures of type 2 conventional dendritic cells acquired these states upon appropriate stimuli.
    [Nature Communications]

    Full Article
    Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.
    REVIEWS

    Targeting Non-Coding RNAs to Overcome Cancer Therapy Resistance

    The authors present the intricate mechanisms through which dysregulated non-coding RNAs control resistance to the four major types of cancer therapies.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Targeting Oncometabolism to Maximize Immunotherapy in Malignant Brain Tumors

    Investigators summarize preclinical and early phase clinical trial research of oncometabolism-based therapeutics that may augment immunotherapy by exploiting the biochemical and genetic underpinnings of brain tumors.
    [Oncogene]

    Abstract

    Overarching Roles of Diacylglycerol Signaling in Cancer Development and Antitumor Immunity

    Exploiting the wide spectrum of diacylglycerol signals from an integrated perspective could underscore meaningful advances in targeted cancer therapy.
    [Science Signaling]

    Abstract
    INDUSTRY AND POLICY NEWS

    BriaCell Receives FDA Fast Track Approval for Targeted Breast Cancer Immunotherapy

    BriaCell Therapeutics Corp., a clinical-stage biotechnology company specializing in targeted immunotherapies for cancer, announced that the US FDA has granted Fast Track status to BriaCell’s lead candidate, Bria-IMT™, for the treatment of metastatic breast cancer.
    [BriaCell Therapeutics Corp.]

    Press Release

    Game Over: Bristol Myers, Nektar End $3.6B Immuno-Oncology Program after Two More Late-Stage Flops

    Bristol Myers Squibb and Nektar have read the last rites to their huge, failed cancer collaboration. With two more late-stage trials failing, the partners have ended clinical development of a combination they once saw as the future of immunooncology.
    [Fierce Biotech]

    Press Release
    FEATURED EVENT

    EMBO Workshop: New Approaches to Combat Antibiotic-Resistant Bacteria

    June 12 – 16, 2022
    Ascona, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – Human Biology

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Research Associate – Molecular Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow/Assistant Staff Scientist – Metabolic Regulation of Innate-Like T cells

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    PhD Position – Tumor Immunology

    University Hospital Carl Gustav Carus Dresden- Dresden, Germany

    Postdoctoral Fellow – Tumor Immunotherapy and Microenvironment

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter