Human Immunology News Volume 10.17 | May 3 2022

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    2022-05-03 | HIN 10.17


    Human Immunology News by STEMCELL Technologies
    Vol. 10.17 – 3 May, 2022
    TOP STORY

    TLR7 Gain-of-Function Genetic Variation Causes Human Lupus

    Investigators identified a de novo, previously undescribed missense TLR7264H variant in a child with severe lupus and additional variants in other patients with lupus.
    [Nature]

    AbstractPress Release

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    Enhanced Safety and Efficacy of Protease-Regulated CAR-T Cell Receptors

    The authors presented SNIP CARs, a protease-based platform for regulating CAR activity using an FDA-approved small molecule.
    [Cell]

    Full ArticleGraphical Abstract

    A T Cell Resilience Model Associated with Response to Immunotherapy in Multiple Tumor Types

    Researchers developed tumor-resilient T cell, a computational model utilizing single-cell transcriptomic data to identify signatures of T cells that were resilient to immunosuppressive signals, such as transforming growth factor-β1, tumor necrosis factor-related apoptosis-inducing ligand and prostaglandin E2.
    [Nature Medicine]

    Abstract

    Expansion of CD4dimCD8+ T Cells Characterizes Macrophage Activation Syndrome and Other Secondary HLH

    Scientists evaluated the activation profile of CD8+ T cells in patients with various forms of secondary hemophagocytic lymphohistiocytosis (HLH), including macrophage activation syndrome.
    [Blood]

    Abstract

    Addition of Interleukin-2 Overcomes Resistance to Neoadjuvant CTLA4 and PD1 Blockade in Ex Vivo Patient Tumors

    Investigators identified a low interleukin 2 gene signature associated with resistance in patients with melanoma. Therapy expanded tumor-specific CD8+ T cells and improved proinflammatory cytokine polyfunctionality of T cells in vivo.
    [Science Translational Medicine]

    Abstract

    Nonlesional Lupus Skin Contributes to Inflammatory Education of Myeloid Cells and Primes for Cutaneous Inflammation

    Researchers analyzed cutaneous lupus erythematosus (CLE) lesions and paired normal-appearing skin biopsies, as well as circulating immune cell subsets, to better understand changes in the skin that drove CLE pathogenesis.
    [Science Translational Medicine]

    Full Article

    Cell Surface–Tethered IL-12 Repolarizes the Tumor Immune Microenvironment to Enhance the Efficacy of Adoptive T Cell Therapy

    The authors described an approach to safely harness cytokine biology for adoptive cell therapy through uniform and dose-controlled tethering onto the surface of the adoptively transferred cells.
    [Science Advances]

    Full Article

    Identification of Four Novel T Cell Autoantigens and Personal Autoreactive Profiles in Multiple Sclerosis

    Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, researchers screened for T cell autoreactivity against 63 CNS-expressed proteins.
    [Science Advances]

    Full ArticlePress Release

    TNF Is a Potential Therapeutic Target to Suppress Prostatic Inflammation and Hyperplasia in Autoimmune Disease

    Scientists utilized medical record data, patient samples, and in vivo models to evaluate the impact of inflammation, as seen in autoimmune diseases, on prostate tissue.
    [Nature Communications]

    Full Article

    A Systems Genomics Approach to Uncover Patient-Specific Pathogenic Pathways and Proteins in Ulcerative Colitis

    Investigators described a precision medicine workflow, the integrated single nucleotide polymorphism network platform (SNP), designed to determine the mechanisms by which SNPs affected cellular regulatory networks, and how SNP co-occurrences contributed to disease pathogenesis in ulcerative colitis.
    [Nature Communications]

    Full Article

    STAT5B Restrains Human B Cell Differentiation to Maintain Humoral Immune Homeostasis

    The authors delineated the unique roles of STAT5 in the activation and differentiation of human naïve and memory B cells.
    [Journal of Allergy and Clinical Immunology]

    Abstract

    Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T Cell Transfer Induces Antitumor Responses against Recurrence of Hepatocellular Carcinoma

    Scientists designed a personalized neoantigen-loaded dendritic cell vaccine and neoantigen-activated T cell therapy and used it as adjuvant therapy to treat ten hepatocellular carcinoma patients who had undergone curative resection or radiofrequency ablation in the first stage of a Phase II trial.
    [Cancer Immunology Research]

    Abstract

    Intratumoral Delivery of a Novel Oncolytic Adenovirus Encoding Human Antibody against PD-1 Elicits Enhanced Antitumor Efficacy

    Researchers constructed an innovative oncolytic virus (OV) based on a chimpanzee adenoviral vector with low seropositivity in the human population, named AdC68-spE1A-αPD-1, which endowed the parental OV with the ability to express full-length anti-human programmed cell death-1 monoclonal antibody.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract

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    REVIEWS

    Membranous Nephropathy: New Pathogenic Mechanisms and Their Clinical Implications

    Insights from studies in patients with membranous nephropathy (MN), combined with the development of novel in vivo and in vitro experimental models, have the potential to improve the management of patients with MN.
    [Nature Reviews Nephrology]

    Abstract

    Impacts and Mechanisms of Metabolic Reprogramming of Tumor Microenvironment for Immunotherapy in Gastric Cancer

    The authors discuss how metabolic reprogramming of gastric cancer (GC) cells and immune cells involved in GC immune responses modulate anti-tumor immune responses, as well as the effects of gastrointestinal flora in tumor microenvironment and GC.
    [Cell Death & Disease]

    Full Article

    Neutrophils and Polymorphonuclear Myeloid-Derived Suppressor Cells: An Emerging Battleground in Cancer Therapy

    Investigators discuss the involvement of polymorphonuclear myeloid-derived suppressor cells in cancer initiation and progression and their potential as therapeutic targets and clinical biomarkers in different cancers.
    [Oncogenesis]

    Full Article

    INDUSTRY AND POLICY NEWS

    NexImmune Announces Preclinical Research Collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center

    NexImmune, Inc. announced a preclinical research collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center.
    [NexImmune, Inc.]

    Press Release

    Prestigious European Grants Awarded to 2 NKI Researchers

    Cancer researchers Drs. Daniel Peeper and Bas van Steensel have each been awarded a European Research Council Advanced Grant. They will be addressing two big questions that science is grappling with: How can we improve immunotherapy for cancer patients? And why is our DNA so messy?
    [Netherlands Cancer Institute]

    Press Release

    European Grants for Groundbreaking Radboudumc Research

    The European Research Council is awarding grants for groundbreaking research to Drs. Roshan Cools and Peter Friedl, both professors at Radboud University Medical Center, Nijmegen, the Netherlands.
    [Radboud UMC]

    Press Release

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – HIV-1 Viral Pathogenesis

    Ragon Institute of MGH, MIT and Harvard – Cambridge, Massachusetts, United States

    Postdoctoral Fellow – Stromal Immune Interactions in Cancer

    Cancer Research Center of Lyon – Lyon, France

    Senior/Laboratory Research Scientist – Infection and Immunity

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Scientist – Vaccine Development

    The Pirbright Institute – Pirbright, England, United Kingdom

    Tenure Track Faculty Position – Cell Signaling

    New York University College of Dentistry – New York, New York, United States

    > See All Jobs

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