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| Investigators identified a de novo, previously undescribed missense TLR7264H variant in a child with severe lupus and additional variants in other patients with lupus. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors presented SNIP CARs, a protease-based platform for regulating CAR activity using an FDA-approved small molecule. [Cell] |
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| Researchers developed tumor-resilient T cell, a computational model utilizing single-cell transcriptomic data to identify signatures of T cells that were resilient to immunosuppressive signals, such as transforming growth factor-β1, tumor necrosis factor-related apoptosis-inducing ligand and prostaglandin E2. [Nature Medicine] |
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| Scientists evaluated the activation profile of CD8+ T cells in patients with various forms of secondary hemophagocytic lymphohistiocytosis (HLH), including macrophage activation syndrome. [Blood] |
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| Investigators identified a low interleukin 2 gene signature associated with resistance in patients with melanoma. Therapy expanded tumor-specific CD8+ T cells and improved proinflammatory cytokine polyfunctionality of T cells in vivo. [Science Translational Medicine] |
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| Researchers analyzed cutaneous lupus erythematosus (CLE) lesions and paired normal-appearing skin biopsies, as well as circulating immune cell subsets, to better understand changes in the skin that drove CLE pathogenesis. [Science Translational Medicine] |
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| The authors described an approach to safely harness cytokine biology for adoptive cell therapy through uniform and dose-controlled tethering onto the surface of the adoptively transferred cells. [Science Advances] |
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| Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, researchers screened for T cell autoreactivity against 63 CNS-expressed proteins. [Science Advances] |
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| Scientists utilized medical record data, patient samples, and in vivo models to evaluate the impact of inflammation, as seen in autoimmune diseases, on prostate tissue. [Nature Communications] |
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| Investigators described a precision medicine workflow, the integrated single nucleotide polymorphism network platform (SNP), designed to determine the mechanisms by which SNPs affected cellular regulatory networks, and how SNP co-occurrences contributed to disease pathogenesis in ulcerative colitis. [Nature Communications] |
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| The authors delineated the unique roles of STAT5 in the activation and differentiation of human naïve and memory B cells. [Journal of Allergy and Clinical Immunology] |
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| Scientists designed a personalized neoantigen-loaded dendritic cell vaccine and neoantigen-activated T cell therapy and used it as adjuvant therapy to treat ten hepatocellular carcinoma patients who had undergone curative resection or radiofrequency ablation in the first stage of a Phase II trial. [Cancer Immunology Research] |
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| Researchers constructed an innovative oncolytic virus (OV) based on a chimpanzee adenoviral vector with low seropositivity in the human population, named AdC68-spE1A-αPD-1, which endowed the parental OV with the ability to express full-length anti-human programmed cell death-1 monoclonal antibody. [Molecular Therapy Oncolytics] |
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| Insights from studies in patients with membranous nephropathy (MN), combined with the development of novel in vivo and in vitro experimental models, have the potential to improve the management of patients with MN. [Nature Reviews Nephrology] |
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| The authors discuss how metabolic reprogramming of gastric cancer (GC) cells and immune cells involved in GC immune responses modulate anti-tumor immune responses, as well as the effects of gastrointestinal flora in tumor microenvironment and GC. [Cell Death & Disease] |
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| Investigators discuss the involvement of polymorphonuclear myeloid-derived suppressor cells in cancer initiation and progression and their potential as therapeutic targets and clinical biomarkers in different cancers. [Oncogenesis] |
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| NexImmune, Inc. announced a preclinical research collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center. [NexImmune, Inc.] |
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| Cancer researchers Drs. Daniel Peeper and Bas van Steensel have each been awarded a European Research Council Advanced Grant. They will be addressing two big questions that science is grappling with: How can we improve immunotherapy for cancer patients? And why is our DNA so messy? [Netherlands Cancer Institute] |
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| The European Research Council is awarding grants for groundbreaking research to Drs. Roshan Cools and Peter Friedl, both professors at Radboud University Medical Center, Nijmegen, the Netherlands. [Radboud UMC] |
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| Ragon Institute of MGH, MIT and Harvard – Cambridge, Massachusetts, United States |
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| Cancer Research Center of Lyon – Lyon, France |
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| Francis Crick Institute – London, England, United Kingdom |
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| The Pirbright Institute – Pirbright, England, United Kingdom |
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| New York University College of Dentistry – New York, New York, United States |
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