 | | Vol. 10.19 – 17 May, 2022 |
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Extricating Human Tumor Immune Alterations from Tissue Inflammation | In an effort to identify tumor-enriched immune alterations, the authors used complementary single-cell analysis approaches to interrogate the immune infiltrate in human head and neck squamous cell carcinomas and site-matched non-malignant, inflamed tissues.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Fundamental Immune-Oncogenicity Trade-Offs Define Driver Mutation Fitness | Scientists developed a model that anticipated patient survival in The Cancer Genome Atlas and patients with lung cancer treated with immunotherapy as well as the age of tumor onset in germline carriers of TP53 variants.
[Nature] |
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Mapping the Developing Human Immune System across Organs | Investigators profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system.
[Science] |
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Cross-Tissue Immune Cell Analysis Reveals Tissue-Specific Features in Humans | Researchers isolated immune cells and performed single-cell RNA sequencing and paired VDJ sequencing for T cell and B cell receptors, resulting in high-quality data for ~330,000 immune cells.
[Science] |
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Sequential Single Cell Transcriptional and Protein Marker Profiling Reveals TIGIT as a Marker of CD19 CAR-T Cell Dysfunction in Patients with Non-Hodgkin’s Lymphoma | To reveal changes in 4-1BB-based CD19 CAR-T cells and identify biomarkers of response, the authors employed single cell RNA sequencing and protein surface marker profiling of patient CAR-T cells pre- and post-infusion into non-Hodgkin’s lymphoma patients.
[Cancer Discovery] |
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An Artificial Intelligence-Guided Signature Reveals the Shared Host Immune Response in MIS-C and Kawasaki Disease | Scientists compared multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease using a computational toolbox of two gene signatures that were developed in the context of SARS-CoV-2 infection.
[Nature Communications] |
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Mast Cell Infiltration of the Choroid and Protease Release Are Early Events in Age-Related Macular Degeneration Associated with Genetic Risk at Both Chromosomes 1q32 and 10q26 | Investigators found that increased mast cell infiltration of the inner choroid, degranulation, and subsequent extracellular matrix remodeling were early events in age-related macular degeneration (AMD) pathogenesis and represented a unifying mechanistic link between chromosome (Chr)1- and Chr10-mediated AMD.
[Proceedings of the National Academy of Sciences of the United States of America] |
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Dynamic Spectrum of Ectopic Lymphoid B Cell Activation and Hypermutation in the RA Synovium Characterized by NR4A Nuclear Receptor Expression | The authors identified a synovial B cell population characterized by co-expression of a family of orphan nuclear receptors, which was highly enriched in rheumatoid arthritis synovial tissue.
[Cell Reports] |
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Loss of T Cell Tolerance in the Skin Following Immunopathology Is Linked to Failed Restoration of the Dermal Niche by Recruited Macrophages | Researchers demonstrated that pathology initiated dermis-specific macrophage differentiation and showed that acute graft-versus-host disease-primed macrophages continued to dominate the dermal compartment at the relative expense of quiescent MHCIIint cells.
[Cell Reports] |
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Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors | Recombinant OR2H1 IgG generated with the VH/VL sequences of a CAR construct specifically detected OR2H1 protein signal in 60 human lung cancers, 40 ovarian carcinomas and 73 cholangiocarcinomas, at positivity rates comparable to mRNA expression and without OR2H1 staining in 58 normal tissues.
[Molecular Cancer therapeutics] |
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RA-MAP, Molecular Immunological Landscapes in Early Rheumatoid Arthritis and Healthy Vaccine Recipients | To investigate the peripheral blood immune cell landscape of early, drug naive rheumatoid arthritis (RA), the authors performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank.
[Scientific Data] |
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Neuropilin-1 Cooperates with PD-1 in CD8+ T Cells Predicting Outcomes in Melanoma Patients Treated with Anti-PD1 | Scientists showed that neuropilin-1 was recruited in the cytolytic synapse of PD1+CD8+ T cells, and cooperated and enhanced PD-1 activity.
[iScience] |
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Melanoma-Specific Antigen-Associated Antitumor Antibody Reactivity as an Immune-Related Biomarker for Targeted Immunotherapies | Researchers applied the next generation phage display mimotope variation analysis to profile antibody response and dissected the role of humoral immunity in targeted cancer therapies, namely anti-tumor dendritic cell vaccine and immunotherapy with anti-PD-1 monoclonal antibodies.
[Communications Medicine] |
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The Impact of the Gut Microbiome on Extra-Intestinal Autoimmune Diseases | The authors describe the compositional and functional changes in the gut microbiota in patients with extra-intestinal autoimmune diseases and discuss how the gut microbiota affects immunity.
[Nature Reviews Immunology] |
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Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity | Scientists discuss the current clinical landscape of immune-checkpoint inhibitors activity in the central nervous system (CNS) and CNS immunobiology, and focus on the role of glial cells in the CNS immune response to brain metastasis.
[Cancer Discovery] |
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Sphingosine 1-Phosphate Receptor-Targeted Therapeutics in Rheumatic Diseases | Investigators review the potential of sphingosine 1-phosphate receptor modulators for the treatment of systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis and summarize the rationale, pathobiology, and evidence from preclinical models and clinical studies.
[Nature Reviews Rheumatology] |
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NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes | NexImmune, Inc., Yale, and JDRF have begun a two-year project to explore the use of NexImmune’s AIM nanoparticles in combination with an anti-CD3 mAb to tolerize, deplete or modulate diabetes antigen-specific T cells.
[NexImmune, Inc.] |
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Evaxion Biotech Announces Successful Production of Personalized Cancer Immunotherapies in Phase I/IIa Clinical Trial for EVX-02 | Evaxion Biotech A/S announced that it has successfully produced all batches of personalized cancer immunotherapies for all patients enrolled in the Phase I/IIa clinical trial of EVX-02 in adjuvant melanoma.
[Evaxion Biotech A/S] |
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Myeloid Therapeutics Doses First Patient with MT-101 in the IMAGINE Phase I/II Clinical Study, Marking the First-ever Dosing of an mRNA Engineered CAR Monocyte to Humans | Myeloid Therapeutics, Inc. announced the first patient dosed in the IMAGINE Study, a Phase I/II clinical study of MT-101, the first mRNA engineered CAR monocyte derived from the company’s proprietary ATAK™ platform, in patients with refractory or relapsed peripheral T cell lymphoma.
[Myeloid Therapeutics, Inc.] |
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LAVA Therapeutics Announces FDA IND Clearance for LAVA-051 for the Treatment of Hematologic Malignancies | LAVA Therapeutics N.V. announced that the US FDA has cleared its investigational new drug (IND) application for LAVA-051, the company’s lead product candidate for the treatment of relapsed or refractory chronic lymphocytic leukemia, multiple myeloma and acute myeloid leukemia.
[LAVA Therapeutics N.V.] |
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| June 17 – 20, 2022
Halifax, Nova Scotia, Canada |
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| | Bristol Myers Squibb – Devens, Massachusetts, United States |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Ragon Institute of MGH, MIT and Harvard – Cambridge, Massachusetts, United States |
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| | Cancer Research Center of Lyon – Lyon, France |
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