 | | Vol. 10.20 – 24 May, 2022 |
| |
|
|
Universal Antigen Encoding of T Cell Activation from High-Dimensional Cytokine Dynamics | Scientists combined a robotic platform with machine learning to experimentally measure and theoretically model CD8+ T cell activation.
[Science] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| STING Agonist Delivery by Tumor-Penetrating PEG-Lipid Nanodiscs Primes Robust Anticancer Immunity | Although cyclic dinucleotides (CDNs) were not directly tumoricidal, lipid nanodisc-CDN uptake by cancer cells correlated with robust T cell activation by promoting CDN and tumor antigen co-localization in dendritic cells.
[Nature Materials] |
|
|
|
Rituximab versus Tocilizumab in Rheumatoid Arthritis: Synovial Biopsy-Based Biomarker Analysis of the Phase IV R4RA Randomized Trial | In-depth histological/molecular analyses of randomized clinical trial in rheumatoid arthritis (R4RA) synovial biopsies identified humoral immune response gene signatures associated with response to rituximab and tocilizumab, and a stromal/fibroblast signature in patients refractory to all medications.
[Nature Medicine] |
|
|
|
Tumor-Induced Erythroid Precursor-Differentiated Myeloid Cells Mediate Immunosuppression and Curtail Anti-PD-1/PD-L1 Treatment Efficacy | Using lineage tracking in cancer patients and tumor-bearing mice, the authors demonstrated that erythroid progenitor cells lost their developmental potential and switched to the myeloid lineage.
[Cancer Cell] |
|
|
|
Emerging Role for Thymic Stromal Lymphopoietin–Responsive Regulatory T Cells in Colorectal Cancer Progression in Humans and Mice | Scientists identified a subset of Tregs expressing the receptor for thymic stromal lymphopoietin that were increased in colorectal tumors in humans and mice and largely absent in adjacent normal colon.
[Science Translational Medicine] |
|
|
|
Integrating Single-Cell RNA Sequencing with Spatial Transcriptomics Reveals Immune Landscape for Interstitial Cystitis | To investigate the role of immunity in interstitial cystitis (IC) bladders, researchers sequenced 135,091 CD45+ immune cells from 15 female patients with IC and 9 controls with stress urinary incontinence using single-cell RNA sequencing.
[Signal Transduction and Targeted Therapy] |
|
|
|
IgA+ Memory B Cells Are Significantly Increased in Patients with Asthma and Small Airways Dysfunction | Patients with severe asthma showed decreased immature B cell populations while memory B cells were significantly increased compared to both mild-moderate asthma patients and healthy controls.
[European Respiratory Journal] |
|
|
|
Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells | Investigators demonstrated that approximately a third of cancer patients analyzed had peripheral CD8+ T cells that expressed robust intracellular lymphocyte activation gene 3 (LAG3), but not surface LAG3 due to A disintegrin and metalloproteinase domain-containing protein 10 cleavage.
[Cancer Immunology Research] |
|
|
|
Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies | From over 35 million assembled complete complementary-determining region 3 sequences, scientists observed that the expression of CCL5 and MZB1 were the most positively correlated genes with T cell clonal expansion and B cell clonal expansion, respectively.
[Cancer Immunology Research] |
|
|
|
Adaptive Immune Signature in HER2-Positive Breast Cancer in NCCTG (Alliance) N9831 and NeoALTTO Trials | The authors identified a novel 17-gene adaptive immune signature, which was found to be significantly associated with improved recurrence-free survival among patients who received adjuvant trastuzumab but not in patients who received chemotherapy alone.
[npj Breast Cancer] |
|
|
|
Regulatory T Cells Induce a Suppressive Immune Milieu and Promote Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma | Highly immunogenic intrahepatic cholangiocarcinomas (ICCs) identified in the public dataset and the Cancer Immunome Atlas were assessed to determine the prognostic impact of immunogenicity in ICC and key components after curative resection.
[British Journal of Cancer] |
|
|
|
Modeling Immune Cytotoxicity for Cholangiocarcinoma with Tumor-Derived Organoids and Effector T Cells | Scientists developed a co-culture method with patient-derived cholangiocarcinoma organoids and immune cells, which could represent anti-cancer immunity in vitro.
[British Journal of Cancer] |
|
|
|
PCBP1 Is Associated with Rheumatoid Arthritis by Affecting RNA Products of Genes Involved in Immune Response in Th1 Cells | Researchers proposed that poly(rC)-binding protein 1 (PCBP1) could play roles in rheumatoid arthritis (RA) by affecting both expression and alternative splicing levels in T helper 1 (Th1) cells. Microarray datasets were used to evaluate the PCBP1 expression changes in RA patients.
[Scientific Reports] |
|
|
|
|
Maternal Immune Protection against Infectious Diseases | Investigators review pre- and postpartum maternal immune factors that protect against infectious agents in offspring and how they may shape the infant’s immune landscape over time.
[Cell Host & Microbe] |
|
|
|
Allergic Asthma Is a Risk Factor for Human Cardiovascular Diseases | Scientists discuss how asthma and allied allergic conditions may contribute to the prevalence, incidence and progression of cardiovascular disease and vice versa.
[Nature Cardiovascular Research] |
|
|
|
|
Abl and Odimma Therapeutics Join Forces in Personalized Cancer Immunotherapy | ABL Europe and Odimma Therapeutics, a young biotechnological company focusing on personalized cancer immunotherapy, announced that they have signed a development agreement.
[Odimma Therapeutics] |
|
|
|
Travere Therapeutics Announces FDA Acceptance and Priority Review of New Drug Application for Sparsentan for the Treatment of IgA Nephropathy | Travere Therapeutics, Inc. announced the US FDA has accepted and granted Priority Review of its New Drug Application under Subpart H for accelerated approval of sparsentan for the treatment of IgA nephropathy.
[Travere Therapeutics, Inc.] |
|
|
|
Nouscom Announces Janssen Receives US FDA IND Clearance for VAC85135, an ‘Off-the-Shelf’ Cancer Immunotherapy Developed Using Nouscom’s Proprietary Viral Vector Platform | Nouscom announced that Janssen Research & Development, LLC received US FDA clearance for its Investigational New Drug (IND) candidate VAC85135, an off-the-shelf, viral vector-based cancer vaccine for an oncologic indication.
[Nouscom] |
|
|
|
Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis | Surrozen, Inc. announced that the first subject has been dosed in its three-part Phase I clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis.
[Surrozen, Inc.] |
|
|
|
|
| June 19 – 24, 2022
Smithfield, Rhode Island, United States |
|
|
|
|
|
| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
|
|
|
| | The Ohio State University – Columbus, Ohio, United States |
|
|
|
| | Karolinska Institute – Stockholm, Sweden |
|
|
|
| | Francis Crick Institute – London, England, United Kingdom |
|
|
|
| | Bristol Myers Squibb – Devens, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
