Human Immunology News Volume 10.21 | May 31 2022

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    2022-05-31 | HIN 10.21


    Human Immunology News by STEMCELL Technologies
    Vol. 10.21 – 31 May, 2022
    TOP STORY

    A Vaccine Targeting Resistant Tumors by Dual T Cell plus NK Cell Attack

    Researchers reported a cancer vaccine that induced a coordinated attack by diverse T cell and NK cell populations. The vaccine targets the MICA and MICB stress proteins expressed by many human cancers as a result of DNA damage.
    [Nature]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Discovery of Bioactive Microbial Gene Products in Inflammatory Bowel Disease

    Investigators systematically identified more than 340,000 protein families as potentially bioactive with respect to gut inflammation during inflammatory bowel disease, about half of which have not to their knowledge been functionally characterized previously on the basis of homology or experiment.
    [Nature]

    Abstract

    Immune Disease Risk Variants Regulate Gene Expression Dynamics during CD4+ T Cell Activation

    Scientists mapped genetic effects on gene expression using single-cell transcriptomics. They profiled 655,349 CD4+ T cells, capturing transcriptional states of unstimulated cells and three time points of cell activation in 119 healthy individuals.
    [Nature Genetics]

    Full ArticlePress Release

    Cytotoxic Innate Lymphoid Cells Sense Cancer Cell-Expressed Interleukin-15 to Suppress Human and Murine Malignancies

    Although clear cell renal cell carcinoma (RCC) was infiltrated by exhaustion-phenotype CD8+ T cells that negatively correlated with patient prognosis, chromophobe RCC had abundant infiltration of granzyme A-expressing intraepithelial type 1 innate lymphoid cells that positively associated with patient survival.
    [Nature Immunology]

    Abstract

    NLRP3 Licenses NLRP11 for Inflammasome Activation in Human Macrophages

    Researchers identified NLRP11 as an essential component of the NLRP3 inflammasome in human macrophages.
    [Nature Immunology]

    Full Article

    MAIT and Vδ2 Unconventional T Cells Are Supported by a Diverse Intestinal Microbiome and Correlate with Favorable Patient Outcome after Allogeneic HCT

    The authors demonstrated that a diverse intestinal microbiome early after allogeneic hematopoietic cell transplantation (HCT) was associated with an increased number of innate-like mucosal-associated invariant T (MAIT) cells, which were in turn associated with improved overall survival.
    [Science Translational Medicine]

    Abstract

    Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade

    Scientists investigated whether in human head and neck squamous cell carcinoma, high levels of expression of stress keratin 17 were associated with poor survival and resistance to immunotherapy.
    [Clinical Cancer Research]

    Abstract

    Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects

    Researchers showed that T follicular helper cells expressed hematopoietic prostaglandin D2 synthase in a pSTAT1/pSTAT3-dependent manner.
    [Cancer Immunology Research]

    Abstract

    The Regulation of CD73 in Non-Small Cell Lung Cancer

    Higher CD73 expression in non-small cell lung cancer cancer cells and patient-derived organoids with EGFR mutation, KRAS mutation or ALK-rearrangement.
    [European Journal of Cancer]

    Abstract

    Immune Checkpoint Inhibitors Alone versus Immune Checkpoint Inhibitors — Combined Chemotherapy for NSCLC Patients with High PD-L1 Expression: A Network Meta-Analysis

    The authors indirectly compared the effects of immune checkpoint inhibitors alone (ICI) and ICI-combined chemotherapy in patients with non-small cell lung cancer (NSCLC) who had high programmed death-ligand 1 (PD-L1) expression through network meta-analyses.
    [British Journal of Cancer]

    Full Article

    Functional Expression of CD73 on Human Natural Killer Cells

    Researchers showed that while NK cells were largely resistant to the upregulation of CD73, CD73 expression was inducible on NK cells in response to CD73 on cancer cells, and these cells were associated with distinct functional signatures.
    [Cancer Immunology Immunotherapy]

    Full Article

    Human CD4+CD25+CD226– Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy

    Investigators suggested that the exclusion of CD226-expressing cells during regulatory T cell (Treg) sorting yielded a population with increased purity, lineage stability, and suppressive capabilities, which may have benefited Treg adoptive cell therapy for the treatment of autoimmune diseases.
    [Frontiers in Immunology]

    Full Article

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    REVIEWS

    Mechanism and Therapeutic Potential of Tumor-Immune Symbiosis in Glioblastoma

    The authors discuss the molecular mechanisms whereby cancer cells shape a myeloid cell-mediated immunosuppressive tumor microenvironment and, reciprocally, how such myeloid cells affect tumor progression and immunotherapy efficiency in glioblastoma.
    [Trends in Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    Umoja Biopharma and Lupagen Announce New Collaboration to Improve Patient Experience and Access to Next-Generation In Vivo Therapeutics for Cancer

    Umoja Biopharma, Inc. and Lupagen, Inc. announced they have entered into a collaboration to evaluate extracorporeal in vivo delivery as a potential additional route of administration for Umoja’s VivoVec particles using Lupagen’s Side CAR-T™ technology.
    [Umoja Biopharma, Inc.]

    Press Release

    Quoin Pharmaceuticals Enters Exclusive Research Agreement for Scleroderma Treatment with Australian University

    Quoin Pharmaceuticals, Ltd. announced it has signed a second exclusive research agreement with the Queensland University of Technology, Australia.
    [Quoin Pharmaceuticals, Ltd.]

    Press Release

    DxTerity Diagnostics Begins Enrollment in the ELEVATE Clinical Study for Lupus

    DxTerity Diagnostics announced the opening of enrollment in Empower Lupus Erythematous Patients Via Allowing RemoTe Evaluation (ELEVATE), a new observational clinical study for patients with systemic lupus erythematosus.
    [DxTerity Diagnostics (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    Translational Immunometabolism

    June 26 – 28, 2022
    Basel, Switzerland

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Human Genomics

    Human Technopole – Milan, Italy

    Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism 

    Van Andel Institute – Grand Rapids, Michigan, United States

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    Postdoctoral Positions – Microbiota and Autoimmunity

    The Ohio State University – Columbus, Ohio, United States

    Director – Vaccine Research Center

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    > See All Jobs

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