 | | Vol. 10.24 – 21 June, 2022 |
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| Scientists reported that bone marrow hematopoietic stem and progenitor cells were skewed toward myeloid lineage concomitant with the clonal expansion of T cells in multiple sclerosis patients.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In patients with non-small cell lung cancer, the group with high tumor mutation burden (TMB) had improved response rates and survival after receiving programmed cell death-1/programmed death-ligand-1 (PD-L1) inhibition therapy across PD-L1 expression subgroups compared with the group with low TMB.
[JAMA Oncology] |
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| Using spatial transcriptomics and proteomics on fresh-frozen human multiple sclerosis (MS) brain tissue, researchers identified multicellular mechanisms of progressive MS pathogenesis and traced their origin in relation to spatially distributed stages of neurodegeneration.
[Nature Neuroscience] |
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| Investigators created organotypic slice cultures from human colorectal cancer liver metastases and tested the antitumor effects of a neutralising antibody against IL-10 both alone as treatment and in combination with exogenously administered carcinoembryonic antigen-specific CAR-T cells.
[Gut] |
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| Scientists showed that a barcoded library of 700,000 unique CD19-specific CARs with diverse intracellular domains cloned into lentiviral vectors and transduced into Jurkat T cells could be screened at high throughput via cell sorting and next-generation sequencing to optimize CAR signaling for antitumoral functions.
[Nature Biomedical Engineering] |
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| Resarchers reported that CD38 reduced CD8+ T cell function by negatively affecting mitochondrial fitness through the inhibition of multiple steps of mitophagy, a process that is critical for mitochondria quality control.
[Science Advances] |
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| The authors presented bead-supported lipid bilayers as versatile synthetic antigen-presenting cells to capture, characterize, and advance the understanding of trans-synaptic vesicle biogenesis.
[Nature Communications] |
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| Tumor-infiltrating lymphocyte-based adoptive cell therapy following concurrent chemoradiotherapy was safe in an academic center setting, with potential effective responses in locally advanced cervical cancer patients.
[Journal of Clinical Investigation] |
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| Scientists conducted a clinical trial in 14 patients with newly diagnosed, human papillomavirus-unrelated head and neck squamous cell carcinoma to evaluate the safety and efficacy of neoadjuvant bintrafusp alfa.
[Journal of Clinical Investigation] |
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| Researchers demonstrated a significant male-biased sexual dimorphism in liver metastasis, which was attributed to host androgen/androgen receptor signaling that promoted hepatic seeding of tumor cells and subsequent outgrowth in a neutrophil-dependent manner.
[Cell Reports] |
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| The authors described a novel in vitro model of exhaustion that employed plate-bound agonists of the NK cell activating receptors NKp46 and NKG2D to induce canonical exhaustion phenotypes.
[JCI Insight] |
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| Mesenchymal stem cells transplantation improved glycated hemoglobin, shifted serum cytokine patterns from pro-inflammatory to anti-inflammatory, increased the number of regulatory T cells in the peripheral blood, and improved quality of life in patients with type 1 diabetes.
[Stem Cell Research & Therapy] |
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| Combined analysis of microarray data and single-cell RNA sequencing data revealed the key interactions between immune cells in the melanoma microenvironment.
[Scientific Reports] |
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| Investigators discuss the general pathophysiological concepts of IL-1-mediated autoinflammation, the epidemiological and clinical features of specific diseases, diagnostic challenges and approaches, and current and future perspectives for therapy.
[Nature Reviews Rheumatology] |
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| Scientists summarize the multilevel relationship between antitumor immunity and non-apoptotic regulated cell death (RCD), including autophagy, ferroptosis, pyroptosis, and necroptosis, and the potential targeting application of non-apoptotic RCD to improve the efficacy of immunotherapy in malignancy.
[Signal Transduction and Targeted Therapy] |
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| The authors discuss the pros and cons of different immune therapies, observed in patients with chronic hepatitis B (CHB) during the last 30 years, to derive insights into the development of an evidence-based, effective, and patient-friendly regimen of immune therapy for the treatment of CHB.
[Journal of Gastroenterology] |
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| With the first generation of CAR-T therapies having shaken up the cancer space, all eyes are on what comes next. So it shouldn’t be a surprise that biotechs have already been in touch with Novartis to see whether they can jump onto the Swiss pharma’s T-Charge platform.
[Fierce Biotech] |
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| NeoImmuneTech’s drug NT-I7 has shown the potential to reduce the number of cells needed in a CAR-T therapy infusion fivefold, as well as boosting survival rates.
[Fierce Biotech] |
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| September 11 – 13, 2022
Lisbon, Portugal |
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| | Mount Sinai School of Medicine – New York, New York, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Aarhus University – Aarhus, Denmark |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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