Human Immunology News Volume 10.26 | Jul 5 2022

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    2022-07-05 | HIN 10.26


    Human Immunology News by STEMCELL Technologies
    Vol. 10.26 – 5 July, 2022
    TOP STORY

    Clonal Structure, Stability and Dynamics of Human Memory B Cells and Circulating Plasmablasts

    Using single-cell sequencing combined with isolation of specific antibodies, the authors found that in two healthy donors, the memory B cell repertoire was dominated by large IgM, IgA, and IgG2 clonal families, whereas IgG1 families, including those specific for recall antigens, were of small size.
    [Nature Immunology]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Oligoclonal T Cell Expansion in a Patient with Bone Marrow Failure after CD19 CAR-T for Richter Transformed DLBCL

    Scientists presented a case of bone marrow failure in a 57-year old man with diffuse large B cell lymphoma (DLBCL)-type Richter transformation receiving tisagenlecleucel in a standard-of-care setting.
    [Blood]

    Abstract

    Immunotherapy of Glioblastoma Explants Induces Interferon-γ Responses and Spatial Immune Cell Rearrangements in Tumor Center, but Not Periphery

    Researchers cultured regionally annotated glioblastoma explants in perfusion bioreactors to assess immune tumor microenvironment responses to immunotherapy.
    [Science Advances]

    Full Article

    Monomethyl Auristatin Antibody and Peptide Drug Conjugates for Trimodal Cancer Chemo-Radio-Immunotherapy

    Investigators reported therapeutic synergies of targeted cytotoxic auristatin radiosensitization to stimulate anti-tumor immune responses providing a rationale for clinical translational of auristatin antibody drug conjugates with radio-immunotherapy combinations to improve tumor control.
    [Nature Communications]

    Full Article

    Atypical Sideways Recognition of CD1a by Autoreactive γδ T Cell Receptors

    The authors used CD1a tetramers to show that CD1a was a ligand for Vδ1+ γδ T cells. Functional studies suggested that two γδ T cell receptors bound CD1a in a lipid-independent manner.
    [Nature Communications]

    Full Article

    Early Expression of Mature αβ TCR in CD4−CD8− T Cell Progenitors Enables MHC to Drive Development of T-ALL Bearing NOTCH Mutations

    Researchers demonstrated that major histocompatibility complex (MHC):T cell antigen receptor signaling could be required to initiate a cancer phenotype from an understudied developmental state that appeared to be represented in the mouse and human disease spectrum.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Prognostic Impact of Performance Status on the Outcomes of Immune Checkpoint Inhibition Strategies in Patients with dMMR/MSI-H Metastatic Colorectal Cancer

    Scientists conducted a global study at Tertiary Cancer Centres and collected data of patients with mismatch repair deficient/ microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer treated with anti-programmed-death (PD)-1 monotherapy or anti-PD-1/anti- cytotoxic T-lymphocyte antigen 4 combination.
    [European Journal of Cancer]

    Abstract

    Modulating T Cell Activation with Antisense Oligonucleotides Targeting Lymphocyte Cytosolic Protein 2

    The authors identified a set of 3′ UTR targeting lymphocyte cytosolic protein 2 (LCP2) antisense oligonucleotides, which knocked down LCP2 in a human T cell line and primary human T cells and found that these suppressed T cell receptor mediated activation.
    [Journal of Autoimmunity]

    Full Article

    The Influence of Nigella sativa Essential Oil on Proliferation, Activation, and Apoptosis of Human T Lymphocytes In Vitro

    Researchers examined the immunomodulatory properties of essential oil obtained from the Nigella sativa seeds by hydrodistillation and its two main constituents: thymoquinone and p-cymene.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    GPR87 Promotes Tumor Cell Invasion and Mediates the Immunogenomic Landscape of Lung Adenocarcinoma

    GPR87 expression in LUAD was positively correlated with immune infiltration. In addition, GPR87 expression was associated with immune and chemotherapy resistance in lung adenocarcinoma patients.
    [Communications Biology]

    Full Article

    A Novel Lipidic Peptide with Potential to Promote Balanced Effector-Regulatory T Cell Responses

    The authors described a lipidic peptide, designated IK14004, that modified crosstalk between T cells and dendritic cells resulting in suppression of IL-12p40/IFN-γ production.
    [Scientific Reports]

    Full Article

    Protein and Functional Isoform Levels and Genetic Variants of the BAFF and APRIL Pathway Components in Systemic Lupus Erythematosus

    Scientists investigated the utility of the cytokine levels in serum and urine as biomarkers, the role of non-functional isoforms, and the association of gene variants with systemic lupus erythematosus.
    [Scientific Reports]

    Full Article

    Reduced Frequencies of Foxp3+GARP+ Regulatory T Cells in COPD Patients Are Associated with Multi-Organ Loss of Tissue Phenotype

    Glycoprotein A dominant repeat (GARP) expression on T cells from peripheral blood and bronchoalveolar lavage collected from patients with chronic obstructive pulmonary disease (COPD) was examined by flow cytometry.
    [Respiratory Research]

    Full Article

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    REVIEWS

    Immunotherapy Approaches for Malignant Pleural Mesothelioma

    The authors summarize the key steps in the development of immunotherapies for mesothelioma, focusing on strategies that have led to randomized clinical evaluation and emerging predictors of response.
    [Nature Reviews Clinical Oncology]

    Abstract

    Pathology of T Cell-Mediated Drug Hypersensitivity Reactions and Impact of Tolerance Mechanisms on Patient Susceptibility

    Scientists focus on T cell reactions and discuss recent advances in disease pathogenesis by exploring the impact of tolerance mechanisms in determining susceptibility in genetically predisposed patients.
    [Current Opinion in Allergy and Clinical Immunology]

    Abstract

    Charting Roadmaps towards Novel and Safe Synergistic Immunotherapy Combinations

    The authors focus on recent developments in immunotherapy combinations and reflect on how combinations should be optimized to maximize the impact of immunotherapy in clinical oncology.
    [Nature Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    Vertex Announces FDA Has Lifted the Clinical Hold on VX-880 Phase I/II Clinical Trial for the Treatment of Type 1 Diabetes

    Vertex Pharmaceuticals announced that the US FDA has lifted the clinical hold placed on the Phase I/II clinical trial of VX-880, a stem cell-derived, fully differentiated pancreatic islet cell replacement therapy for people with type 1 diabetes with impaired hypoglycemic awareness and severe hypoglycemia.
    [Vertex Pharmaceuticals Incorporated]

    Full Article

    Skyhawk Therapeutics Announces Expansion of its Collaboration Agreement with Merck to Discover and Develop Novel Small Molecules that Modulate RNA Splicing

    Skyhawk Therapeutics, Inc. announced the signing of an exclusive worldwide collaboration agreement with Sanofi to discover and develop novel small molecules that modulate RNA splicing for challenging oncology and immunology targets.
    [Skyhawk Therapeutics, Inc.]

    Press Release

    BriaCell Partners with Waisman Biomanufacturing to Manufacture and Supply Prostate Cancer Immunotherapy

    BriaCell Therapeutics Corp. has entered a manufacturing service agreement with Waisman Biomanufacturing at the University of Wisconsin–Madison, to manufacture Bria-Pros™, BriaCell’s off-the-shelf personalized immunotherapy for prostate cancer, for anticipated use in clinical studies.
    [BriaCell Therapeutics Corp.]

    Press Release

    FEATURED EVENT

    The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

    November 16 – 18, 2022
    Melbourne, Victoria, Australia

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immuno-Engineering

    Georgia Institute of Technology – Atlanta, Georgia, United States

    Postdoctoral Fellow Positions – Translational Research

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Postdoctoral Researcher – Autoimmunity

    Philipps University of Marburg – Marburg, Germany

    Postdoctoral Fellow – Cancer Biology and Cancer Immunology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Senior Lecturer – Immunology

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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