Human Immunology News Volume 10.28 | Jul 19 2022

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    2022-07-19 | HIN 10.28


    Human Immunology News by STEMCELL Technologies
    Vol. 10.28 – 19 July, 2022
    TOP STORY

    Pre-Encoded Responsiveness to Type I Interferon in the Peripheral Immune System Defines Outcome of PD1 Blockade Therapy

    Investigators developed a mass cytometry approach to quantify IFN-I-stimulated protein expression across immune cells and used multi-omics to uncover pre-therapy cellular states encoding responsiveness to inflammation.
    [Nature Immunology]

    Full Article

    Learn how to edit human Natural Killer (NK) cells using CRISPR-Cas9 with the help of this step-by-step protocol.
    PUBLICATIONSRanked by the impact factor of the journal

    Local Delivery of Low-Dose Anti–CTLA-4 to the Melanoma Lymphatic Basin Leads to Systemic Treg Reduction and Effector T Cell Activation

    The authors evaluated the safety, tolerability, and immunomodulatory effects in the sentinel lymph node (SLN) and peripheral blood of a single dose of tremelimumab in a dose range of 2 to 20 mg, injected intradermally at the tumor excision site one week before SLN biopsy in 13 patients with early-stage melanoma.
    [Science Immunology]

    Full Article

    Integration of Tumor Extrinsic and Intrinsic Features Associates with Immunotherapy Response in Non-Small Cell Lung Cancer

    Scientists used single-cell profiling to identify tumor-infiltrating, clonally expanded CD4+ T cells that expressed a canonical cytotoxic gene program and non-small cell lung cancer cells with elevated HLA-II expression.
    [Nature Communications]

    Full Article

    Single Cell Sequencing Identifies Clonally Expanded Synovial CD4+ TPH Cells Expressing GPR56 in Rheumatoid Arthritis

    Researchers performed single cell sequencing on synovial CD4+ T cells from anti-citrullinated protein antibodies (ACPA)+ and ACPA- rheumatoid arthritis patients and identified two peripheral helper T cell (TPH) states and a cytotoxic CD4+ T cell subset.
    [Nature Communications]

    Full Article

    Epigenetic Modulators of B Cell Fate Identified through Coupled Phenotype-Transcriptome Analysis

    The authors revealed that polycomb repressive complex 2 inhibitors promoted antibody secreting cell differentiation in both murine and human B cells in vitro.
    [Cell Death & Differentiation]

    Full Article

    Monocytic Myeloid-Derived Suppressive Cells Mitigate Over-Adipogenesis of Bone Marrow Microenvironment in Aplastic Anemia by Inhibiting CD8+ T Cells

    Activated CD8+ T cells and interferon-γ were found to stimulate adipogenesis of bone marrow-mesenchymal stromal cells either in vitro or in vivo of aplastic anemia mouse model.
    [Cell Death & Disease]

    Full Article

    Impact of Anti-T-Lymphocyte Globulin Dosing on GVHD and Immune Reconstitution in Matched Unrelated Myeloablative Peripheral Blood Stem Cell Transplantation

    Researchers compared graft versus host disease (GVHD) and immune reconstitution after myeloablative matched unrelated peripheral blood stem cell allogeneic stem cell transplant between 30 mg/Kg and 60 mg/Kg anti-lymphocyte globulin.
    [Bone Marrow Transplantation]

    Full Article

    CC Chemokine Receptor 2 (CCR2) Expression Promotes Diffuse Large B Cell Lymphoma Survival and Invasion

    Scientists showed that CCR2 overexpression was an independent prognostic marker and predicted shorter overall survival and progression-free survival in patients with diffuse large B cell lymphoma.
    [Laboratory Investigation]

    Abstract

    The Metabolic Profile of Reconstituting T Cells, NK Cells, and Monocytes following Autologous Stem Cell Transplantation and Its Impact on Outcome

    Since immune cell metabolism and function are closely interconnected, the authors used flow-cytometry techniques to analyze key components and functions of the metabolic machinery in reconstituting immune cells upon high-dose chemotherapy/autologous stem cell transplantation.
    [Scientific Reports]

    Full Article

    Presence of Periodontitis May Synergistically Contribute to Cancer Progression via Treg and IL-6

    Researchers investigated the relationship between immune surveillance mechanisms and periodontitis in cancer patients. They assessed the presence or absence of periodontitis and measured the peripheral blood concentrations of IL-6, immunosuppressive cytokines, and proportion of T regulatory cells (Treg).
    [Scientific Reports]

    Full Article

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    REVIEWS

    Immune-Based Therapies in Penile Cancer

    To address the unmet need for treatment modalities with increased effectiveness, immune-based therapies such as immune-checkpoint blockade, human papilloma virus-directed vaccines and adoptive T cell therapies have emerged as potential treatment options for advanced penile cancer.
    [Nature Reviews Urology]

    Abstract

    Targeting Glycans for CAR Therapy: The Advent of Sweet CARs

    Scientists discuss the state of CAR T cells in the therapy of solid tumors, the cancer glycoproteome and its potential for use as a therapeutic target, and the landscape and future of glycan-binding CAR T cell therapy.
    [Molecular Therapy]

    Abstract

    Cancer Vaccine Strategies Using Self-Replicating RNA Viral Platforms

    The authors summarize different types of self-replicating RNA platforms that have emerged and review evidence for their efficacy in provoking anti-tumor immunity to different antigens.
    [Cancer Gene Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    Enterome Signs Major Strategic R&D Collaboration with Nestlé Health Science to Develop and Commercialize New AllerMimics™ and EndoMimics™ Immunotherapies for Food Allergies and Inflammatory Bowel Disease

    Enterome announced that it has signed a strategic R&D collaboration and license agreement with Nestlé Health Science targeting food allergies and inflammatory bowel disease.
    [Enterome]

    Press Release

    Prometheus Biosciences Completes Enrollment of the ARTEMIS-UC Cohort 1 Phase II Study in Ulcerative Colitis

    Prometheus Biosciences, Inc. announced the completion of enrollment for Cohort 1 of the ARTEMIS-UC global Phase II study of PRA023 in ulcerative colitis.
    [Prometheus Biosciences, Inc.]

    Press Release

    FEATURED EVENT

    The Immunoreceptors and Immunotherapy Conference

    July 17 – 21, 2022
    Gothenburg, Sweden

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    JOB OPPORTUNITIES

    Research Assistant Tech – Microbiology & Immunology

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Cancer Immunology

    Genentech, Inc – South San Francisco, California, United States

    Postdoctoral Researcher – Translational Vascular Biology

    University Hospital of Muenster – Münster, Germany

    Postdoctoral Position – T Cell Development

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellow – Thoracic Malignancies

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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