| Vol. 10.28 – 19 July, 2022 |
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| Investigators developed a mass cytometry approach to quantify IFN-I-stimulated protein expression across immune cells and used multi-omics to uncover pre-therapy cellular states encoding responsiveness to inflammation. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors evaluated the safety, tolerability, and immunomodulatory effects in the sentinel lymph node (SLN) and peripheral blood of a single dose of tremelimumab in a dose range of 2 to 20 mg, injected intradermally at the tumor excision site one week before SLN biopsy in 13 patients with early-stage melanoma. [Science Immunology] |
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| Scientists used single-cell profiling to identify tumor-infiltrating, clonally expanded CD4+ T cells that expressed a canonical cytotoxic gene program and non-small cell lung cancer cells with elevated HLA-II expression. [Nature Communications] |
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| Researchers performed single cell sequencing on synovial CD4+ T cells from anti-citrullinated protein antibodies (ACPA)+ and ACPA- rheumatoid arthritis patients and identified two peripheral helper T cell (TPH) states and a cytotoxic CD4+ T cell subset. [Nature Communications] |
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| The authors revealed that polycomb repressive complex 2 inhibitors promoted antibody secreting cell differentiation in both murine and human B cells in vitro. [Cell Death & Differentiation] |
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| Activated CD8+ T cells and interferon-γ were found to stimulate adipogenesis of bone marrow-mesenchymal stromal cells either in vitro or in vivo of aplastic anemia mouse model. [Cell Death & Disease] |
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| Researchers compared graft versus host disease (GVHD) and immune reconstitution after myeloablative matched unrelated peripheral blood stem cell allogeneic stem cell transplant between 30 mg/Kg and 60 mg/Kg anti-lymphocyte globulin. [Bone Marrow Transplantation] |
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| Scientists showed that CCR2 overexpression was an independent prognostic marker and predicted shorter overall survival and progression-free survival in patients with diffuse large B cell lymphoma. [Laboratory Investigation] |
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| Since immune cell metabolism and function are closely interconnected, the authors used flow-cytometry techniques to analyze key components and functions of the metabolic machinery in reconstituting immune cells upon high-dose chemotherapy/autologous stem cell transplantation. [Scientific Reports] |
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| Researchers investigated the relationship between immune surveillance mechanisms and periodontitis in cancer patients. They assessed the presence or absence of periodontitis and measured the peripheral blood concentrations of IL-6, immunosuppressive cytokines, and proportion of T regulatory cells (Treg). [Scientific Reports] |
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| To address the unmet need for treatment modalities with increased effectiveness, immune-based therapies such as immune-checkpoint blockade, human papilloma virus-directed vaccines and adoptive T cell therapies have emerged as potential treatment options for advanced penile cancer. [Nature Reviews Urology] |
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| Scientists discuss the state of CAR T cells in the therapy of solid tumors, the cancer glycoproteome and its potential for use as a therapeutic target, and the landscape and future of glycan-binding CAR T cell therapy. [Molecular Therapy] |
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| The authors summarize different types of self-replicating RNA platforms that have emerged and review evidence for their efficacy in provoking anti-tumor immunity to different antigens. [Cancer Gene Therapy] |
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| Enterome announced that it has signed a strategic R&D collaboration and license agreement with Nestlé Health Science targeting food allergies and inflammatory bowel disease. [Enterome] |
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| Prometheus Biosciences, Inc. announced the completion of enrollment for Cohort 1 of the ARTEMIS-UC global Phase II study of PRA023 in ulcerative colitis. [Prometheus Biosciences, Inc.] |
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| July 17 – 21, 2022 Gothenburg, Sweden |
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| University of British Columbia – Vancouver, British Columbia, Canada |
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| Genentech, Inc – South San Francisco, California, United States |
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| University Hospital of Muenster – Münster, Germany |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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