Human Immunology News Volume 10.29 | Jul 26 2022

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    2022-07-26 | HIN 10.29


    Human Immunology News by STEMCELL Technologies
    Vol. 10.29 – 26 July, 2022
    TOP STORY

    Uncovering the Mode of Action of Engineered T Cells in Patient Cancer Organoids

    Scientists described a system, called BEHAV3D, developed to study the dynamic interactions of immune cells and patient cancer organoids by means of imaging and transcriptomics.
    [Nature Biotechnology]

    Full Article

    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Human T-Bet Governs the Generation of a Distinct Subset of CD11chighCD21low B Cells

    Researchers described a patient with inherited T-bet deficiency and largely normal humoral immunity including intact somatic hypermutation, affinity maturation, and memory B cell formation in vivo, and B cell differentiation into Ig-producing plasmablasts in vitro.
    [Science Immunology]

    Abstract

    Hypoxia Induces HIF1α-Dependent Epigenetic Vulnerability in Triple Negative Breast Cancer to Confer Immune Effector Dysfunction and Resistance to Anti-PD-1 Immunotherapy

    Using an in vitro culture system modeling human T cell dysfunction and exhaustion in triple-negative breast cancer, the authors found that hypoxia suppressed immune effector gene expression, including in T and NK cells, resulting in immune effector cell dysfunction and resistance to immunotherapy.
    [Nature Communications]

    Full Article

    Nanocarriers Based on Bacterial Membrane Materials for Cancer Vaccine Delivery

    Investigators developed two different types of nanocarrier based on bacterial membrane materials, which employed genetically engineered outer membrane vesicles, or hybrid membrane vesicles containing bacterial cytoplasmic membrane, respectively.
    [Nature Protocols]

    Full Article

    Interferon-β Regulates Proresolving Lipids to Promote the Resolution of Acute Airway Inflammation

    The authors reported that interferon-β exerted partially overlapping, but also cooperative actions with aspirin-triggered 15-epi-lipoxin A4 and 17-epi-resolvin D1 to counter TLR9-generated cues to regulate neutrophil apoptosis and phagocytosis in human neutrophils.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    ROR1-Targeting Switchable CAR-T Cells for Cancer Therapy

    To explore the therapeutic utility of switchable CAR-T cells targeting the receptor tyrosine kinase ROR1, a panel of switches based on ROR1-targeting Fabs with different epitopes and affinities was compared in in vitro and in vivo models of ROR1-expressing cancers.
    [Oncogene]

    Full Article

    FOXM1 Network in Association with TREM1 Suppression Regulates NET Formation in Diabetic Foot Ulcers

    Investigators found that FOXM1 regulated reactive oxygen species (ROS) levels in neutrophils and inhibition of FOXM1 resulted in increased ROS leading to neutrophil extracellular trap (NET) formation.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Somatic Mutations in DCC Are Associated with Genomic Instability and Favourable Outcomes in Melanoma Patients Treated with Immune Checkpoint Inhibitors

    The authors performed an integrated study based on biological experiments and multi-dimensional data types, including genomic, transcriptomic, and clinical immune checkpoint blockade-treated melanoma cohorts from public databases.
    [British Journal of Cancer]

    Abstract

    B Cell Acute Lymphoblastic Leukemia Promotes an Immune Suppressive Microenvironment That Can Be Overcome by IL-12

    Plasma collected from children with B cell acute lymphoblastic leukemia with measurable residual disease after induction chemotherapy showed differential cytokine expression while single-cell RNA-sequencing revealed the expression of genes associated with immune exhaustion in immune cell subsets.
    [Scientific Reports]

    Full Article

    Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis

    Researchers studied synovial biopsies captured from untreated rheumatoid arthritis patients at the time of diagnosis and found that the tissue architecture implicated both local B cell maturation via T cell help and plasma cell survival niches with a strong CXCL12–CXCR4 axis.
    [Scientific Reports]

    Full Article

    Autoantibodies to IgE Can Induce the Release of Proinflammatory and Vasoactive Mediators from Human Cardiac Mast Cells

    Scientists compared the effects of different preparations of IgG anti-IgE obtained from patients with atopic dermatitis with rabbit IgG anti-IgE on the release of preformed and lipid mediators from cardiac mast cells.
    [Clinical and Experimental Medicine]

    Full Article

    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    Natural Killer Cells in Antitumor Adoptive Cell Immunotherapy

    Investigators describe the various approaches to augment NK cell cytotoxicity and longevity, evaluate challenges and opportunities, and reflect on how lessons learned from the clinic will guide the design of next-generation NK cell products that will address the unique complexities of each cancer.
    [Nature Reviews Cancer]

    Full Article

    The Complex Role of Tumor-Infiltrating Macrophages

    The authors outline hallmarks of tumor-associated macrophages and discuss the emerging mechanisms that contribute to their pathophysiological adaptations and the vulnerabilities that provide attractive targets for therapeutic exploitation in cancer.
    [Nature Immunology]

    Full Article

    Immune Senescence in Multiple Myeloma — a Role for Mitochondrial Dysfunction?

    Scientists outline our current understanding of normal immune aging, describe the mechanism of immunometabolic dysfunction in accelerating this process, and propose the role these processes are playing in the pathogenesis of multiple myeloma.
    [Leukemia]

    Full Article

    INDUSTRY AND POLICY NEWS

    Cancer Research UK and Sosei Heptares Sign Agreement to Advance Cancer Immunotherapy Candidate into Clinical Trials

    Sosei Group Corporation and Cancer Research UK announced the signing of an agreement to bring Sosei Heptares’ cancer immunotherapy drug candidate into a first-in-human trial.
    [Sosei Group Corporation]

    Press Release

    F-star Therapeutics Announces a License Agreement with Takeda for a Novel Next-Generation Immuno-Oncology Bispecific Antibody

    F-star Therapeutics, Inc. announced that it has entered into a license agreement with Takeda. F-star will grant Takeda a license to research, develop, and commercialize a bispecific antibody against an immuno-oncology target using F-star’s proprietary Fcab™ and mAb2™ platforms.
    [F-star Therapeutics, Inc.]

    Press Release

    Artizan Biosciences Announces Multi-Year Research Collaboration with the University Medical Center Utrecht and Microviable Therapeutics SL

    Artizan Biosciences, Inc. announced that it has entered into a multi-year research collaboration with the University Medical Center Utrecht in The Netherlands and Microviable Therapeutics SL to explore the role that gut microbiota may have in immune checkpoint inhibitor therapies for patients with cancer.
    [Artizan Biosciences, Inc.]

    Press Release

    FEATURED EVENT

    The Translational Neuroimmunology Conference: From Bench to Bedside and Back

    August 28 – September 2, 2022
    Asheville, North Carolina, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Fellow – Cancer Immunology

    Genentech, Inc. – South San Francisco, California, United States

    Postdoctoral Position – T Cell Development

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Researcher – Translational Vascular Biology

    University Hospital of Muenster – Münster, Germany

    Postdoctoral Fellow – Thoracic Malignancies

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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