Defective PTEN Regulation Contributes to B Cell Hyperresponsiveness in Systemic Lupus Erythematosus Investigators performed fluorescence-activated cell sorting analysis in B cells from systemic lupus erythematosus (SLE) patients and found that all SLE B cell subsets, except for memory B cells, showed decreased expression of PTEN compared with B cells from healthy controls. [Sci Transl Med] Abstract Activated Innate Lymphoid Cells Are Associated with a Reduced Susceptibility to Graft-versus-Host Disease Researchers investigated longitudinally the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic hematopoietic stem cell transplantation on composition, phenotype, and recovery of circulating innate lymphoid cells in 51 acute leukemia patients. [Blood] Abstract Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms’ Tumor 1 (WT1)-Specific MHC Class I/II-Restricted Epitopes for Pancreatic Cancer Researchers performed a Phase I trial to investigate the safety, clinical responses, and WT1-specific immune responses following treatment with dendritic cells pulsed with a mixture of three types of WT1 peptides, including both MHC class I and II-restricted epitopes, in combination with chemotherapy. [Clin Cancer Res] Abstract Effective Treatment with Intravenous Immunoglobulins Reduces Autoreactive T-Cell Response in Patients with CIDP The authors investigated changes in autoreactive T-cell responses against PMP-22 and P2 antigen as well as a T-cell memory repertoire in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) induced by repeated intravenous immunoglobulin treatment. [J Neurol Neurosurg Psychiatry] Abstract TLR4 Activation Enhances the PD-L1-Mediated Tolerogenic Capacity of Colonic CD90+ Stromal Cells Researchers demonstrate that stimulation of TLR4 on human CD90+ myofibroblasts/fibroblasts (CMFs) upregulates programmed cell death-1 (PD-L1), but not PD-L2, and reinforces CMF-mediated suppression of CD4+ T cell proliferation and IFN-γ production. [J Immunol] Abstract Inflammatory Conditions Distinctively Alter Immunological Functions of Langerhans-Like Cells and Dendritic Cells In Vitro Scientists investigated the immune responses of human immature monocyte-derived dendritic cells and Langerhans cell-like cells upon stimulation with different TLR ligands in the presence or absence of pro-inflammatory cytokines TNF-α and IL-1β. [Immunology] Abstract Human Treg Cells Are Characterized by Low/Negative CD6 Expression Researchers present evidence that CD4+CD25hiCD6lo/- natural regulatory T (Treg) cells have high expression of FOXP3 and exhibit in vitro suppressive activity on CD8+ T-cell proliferation. [Cytometry A] Abstract The Role of CD4+ T Cells in BKV-Specific T Cell Immunity Scientists demonstrate a comprehensive flow cytometric analysis of the polyomavirus BK (BKV)-specific T cell response that permits access to the majority of T cells specific for immunodominant BKV antigens. [Med Microbiol Immunol] Abstract Modulation of Both Activator Protein-1 and Nuclear Factor-Kappa B Signal Transduction of Human T Cells by Amiodarone Amiodarone, a common and effective antiarrhythmic drug, has been reported to have anti-inflammatory effects such as reducing the activation and movement of neutrophils. Investigators elucidated the effects and possible underlying mechanisms of amiodarone on human T cells. [Exp Biol Med] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |