Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages Using a proteomics approach, researchers show that markers of classical activation are absent on adipose tissue macrophages from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis. They identify PPARγ and p62/SQSTM1 as two key proteins that promote lipid metabolism and limit inflammation in metabolically activated macrophages. [Cell Metab] Abstract | Graphical Abstract Anti-CTLA-4 Therapy Broadens the Melanoma-Reactive CD8+ T Cell Response It is unclear whether anti-CTLA-4 treatment amplifies previously induced T cell responses or whether it induces new tumor-specific T cell reactivities. Using a combination ultraviolet-induced peptide exchange and peptide-major histocompatibility complex combinatorial coding, scientists monitored immune reactivity against a panel of 145 melanoma-associated epitopes in a cohort of patients receiving anti-CTLA-4 treatment. [Sci Transl Med] Abstract Enhanced Natural Killer-Cell and T-Cell Responses to Influenza A Virus during Pregnancy Although some data suggest that natural killer- and T-cell responses are suppressed during pregnancy, influenza-specific responses have not been previously evaluated. Investigators analyzed the responses of women that were pregnant versus those that were not immediately before inactivated influenza vaccination, seven days after vaccination, and six weeks postpartum. [Proc Natl Acad Sci USA] Abstract Regulation of T Cell Proliferation by JMJD6 and PDGF-BB during Chronic Hepatitis B Infection Scientists demonstrate that jumonji domain-containing protein 6 (JMJD6) is a potential regulator of T cell proliferation during chronic hepatitis B virus infection. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B patients, and this reduction in JMJD6 expression was associated with impaired T cell proliferation. [Sci Rep] Full Article Expression of Coinhibitory Receptors on T Cells in the Microenvironment of Usual Vulvar Intraepithelial Neoplasia Is Related to Proinflammatory Effector T Cells and an Increased Recurrence-Free Survival Scientists show that the vulva constitutes an area intensely surveyed by CD8+, CD4+, Tbet+ and regulatory T cell populations, parts of which express examined coinhibitory molecules. In usual-type vulvar intraepithelial neoplasia especially, the number of regulatory T cells and TIM3+ T cells increased. [Int J Cancer] Abstract Expression and DNA Methylation of TNF, IFNG and FOXP3 in Colorectal Cancer and Their Prognostic Significance Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Scientists assessed the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. [Br J Cancer] Full Article In Situ Immune Response in Human Chromoblastomycosis – A Possible Role for Regulatory and Th17 T Cells The cellular immune response in the severe form of chromoblastomycosis seems to correlate with a Th2 pattern of cytokines. The humoral immune response also seems to play a role. Investigators intended to explore the populations of regulatory T cells and the Th17 pattern. [PLoS Negl Trop Dis] Full Article Sequential Immune Monitoring in Patients with Melanoma and Renal Cell Carcinoma Treated with High-Dose Interleukin-2: Immune Patterns and Correlation with Outcome Researchers hypothesized that changes in T cell subset distribution in patients undergoing interleukin (IL)-2 therapy may correlate with treatment outcomes. Changes in distribution and phenotype of circulating CD4 and CD8 lymphocyte subsets were compared based on cancer types and intra-patient during the course of the IL-2 therapy. [Cancer Immunol Immunother] Abstract Clinical Cell Therapy Imaging Using a Perfluorocarbon Tracer and Fluorine-19 MRI To accelerate clinical translation, noninvasive imaging of cell grafts in clinical trials can potentially be used to assess the initial delivery and behavior of cells. This technology was used to detect immunotherapeutic dendritic cells delivered to colorectal adenocarcinoma patients. [Magn Reson Med] Full Article | Press Release Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |