A Spaetzle-Like Role for Nerve Growth Factor β in Vertebrate Immunity to Staphylococcus aureus Nerve growth factor β was released by macrophages in response to S. aureus exoproteins through activation of the NOD-like receptors NLRP3 and NLRP4 and enhanced phagocytosis and superoxide-dependent killing, stimulated proinflammatory cytokine production, and promoted calcium-dependent neutrophil recruitment. [Science] Abstract Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression Monocytes and macrophages are major components of the tumor microenvironment, but their contributions to human cancer are poorly understood. Investigators used molecular profiling combined with functional assays to investigate the role of these cells in human renal cell carcinoma. [Immunity] Abstract Human NLRP3 Inflammasome Senses Multiple Types of Bacterial RNAs Investigators report that all three types of bacterially derived RNA (mRNA, tRNA, and rRNAs) were capable of activating the nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome in human macrophages. [Proc Natl Acad Sci USA] Abstract Cellular and Molecular Immune Profiles in Renal Transplant Recipients after Conversion from Tacrolimus to Sirolimus Tacrolimus and sirolimus are commonly used maintenance immunosuppressants in kidney transplantation. As their effects on immune cells and allograft molecular profiles have not been elucidated, scientists characterized the effects of tacrolimus to sirolimus conversion on the frequency and function of T cells, and on graft molecular profiles. [Kidney Int] Abstract Expression Profiles of Long Non-Coding RNAs Located in Autoimmune Disease-Associated Regions Reveal Immune Cell Type Specificity Scientists characterized long non-coding RNA transcripts and protein-coding genes located in loci associated with nine autoimmune and immune-related disorders which have been well-defined by Immunochip analysis and by transcriptome analysis across seven populations of peripheral blood leukocytes and four populations of cord blood-derived T-helper cells. [Genome Med] Abstract | Full Article Novel Expression of Neuropilin 1 on Human Tumor-Infiltrating Lymphocytes in Colorectal Cancer Liver Metastases Scientists investigated neuropilin 1 (NRP1) expression on tumor-infiltrating lymphocytes and peripheral blood mononuclear cells (PBMCs) from colorectal cancer liver metastases. PBMCs were co-cultured in vitro with tumor tissue and analyzed for NRP1 expression. [Expert Opin Ther Targets] Abstract Estrogen Upregulates MICA/B Expression in Human Non-Small Cell Lung Cancer through the Regulation of ADAM17 Whether estrogen regulates MICA/B expression and affects tumor immune escape remains unknown. Investigators found that estradiol enhanced the expression of ADAM17, which was associated with the secretion of MICA/B. This secretion of MICA/B downregulated the NKG2D receptor on the surface of natural killer (NK)92 cells and impaired the cytotoxic activity of NK cells. [Cell Mol Immunol] Abstract The Presence of Interleukin-27 during Monocyte-Derived Dendritic Cell Differentiation Promotes Improved Antigen Processing and Stimulation of T Cells Researchers show that interleukin (IL)-27 treatment during monocyte-derived dendritic cell (DC) differentiation enhanced the ability to process antigens and stimulate T cell activity. DCs differentiated in the presence of IL-27 showed enhanced acidification of latex bead-containing phagosomes that was consistent with elevated expression of vacuolar-ATPases. [Immunology] Abstract Amniotic Membrane Mesenchymal Cells-Derived Factors Skew T Cell Polarization toward Treg and Downregulate Th1 and Th17 Cells Subsets In order to understand the mechanisms involved in immune regulation exerted by human amniotic mesenchymal stromal cells (hAMSC), researchers analyzed the effects of conditioned medium derived from the culture of hAMSC on T-cell polarization towards Th1, Th2, Th17, and T-regulatory (Treg) subsets. [Stem Cell Rev Rep] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |