Syk Is Indispensable for CpG-Induced Activation and Differentiation of Human B Cells Investigators describe a so far unidentified, spleen tyrosine kinase (Syk)-dependent pathway, which is indispensable for CpG-induced human B cell activation. They show that triggering of B cells by CpG results in Syk and src kinase phosphorylation, proliferation, as well as cytokine and antibody production independent of the BCR. [Cell Mol Life Sci] Abstract CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway Scientists examined the expression of inhibitory molecules induced via CD26-mediated costimulation. They show that coengagement of CD3 and CD26 induces preferential production of IL-10 in human CD4+ T cells, mediated through NFAT and Raf-MEK-ERK pathways. [J Immunol] Abstract Combination Therapy with Anti-CTLA-4 and Anti-PD-1 Leads to Distinct Immunologic Changes In Vivo Investigators show that blockade of CTLA-4, PD-1, or combination of the two leads to distinct genomic and functional signatures in vivo in purified human T cells and monocytes. [J Immunol] Abstract Induced Expression of FcγRIIIa (CD16a) on CD4+ T Cells Triggers Generation of IFN-γhigh Subset The authors show that a subset of activated CD4+ T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune complexes in human CD4+ T-cells produced co-stimulatory signal like CD28 that triggered IFN-γ production. [J Biol Chem] Abstract | Full Article Monocyte-Derived Dendritic Cells Can Induce Autoreactive CD4+ T Cells Showing Myeloid Lineage-Directed Reactivity in Healthy Individuals Researchers show that a minority of naive and memory CD4+ T cells within the healthy human T-cell repertoire mediates HLA-restricted reactivity against autologous monocyte-derived dendritic cells which behave like a normal antigen-specific immune response. [Eur J Immunol] Abstract IL-34- and M-CSF-Induced Macrophages Switch Memory T Cells into Th17 Cells via Membrane IL-1α Scientists evaluated the capacity of human macrophages induced in the presence of M-CSF or IL-34 and ovarian cancer tumor-associated macrophages to modulate the phenotype of human CD4+ T cells. [Eur J Immunol] Abstract IL-17 Induces Radiation Resistance of B Lymphoma Cells by Suppressing p53 Expression and Thereby Inhibiting Irradiation-Triggered Apoptosis A human B lymphoma cell line, Karpas1106 (k1106), was used as a model of radioresistance. When k1106 cells were cocultured with regulatory T cells and irradiated, the rate of apoptotic k1106 cells was significantly reduced, indicating an acquired resistance to irradiation. [Cell Mol Immunol] Abstract Generation of Tumor-Specific Cytotoxic T-Lymphocytes from the Peripheral Blood of Colorectal Cancer Patients for Adoptive T-Cell Transfer Researchers designed a strategy for an ACT protocol based on the ex vivo selection of autologous peripheral blood-derived CD8-enriched T-cells, stimulated with dendritic cells that had been pulsed with apoptotic tumor cells to generate cytotoxic T lymphocytes with anti-tumor activity. [J Cell Physiol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |