Restricted Specificity of Peripheral Alloreactive Memory B Cells in HLA-Sensitized Patients Awaiting a Kidney Transplant Scientists tested the presence of circulating alloreactive memory B cells in 69 patients with end-stage renal disease under renal replacement therapy, using an in vitro memory B cell-stimulation assay combined with identification of IgG human leukocyte antigen (HLA) antibodies in culture supernatant. [Kidney Int] Abstract Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation Using targeted bisulfite sequencing, investigators examined methylation of 2100 genes (56,000 CpGs) mapped by deep sequencing of T cell activation in human naive and memory CD4 T cells. Four hundred sixty-six CpGs displayed differential methylation between naive and memory cells. [J Immunol] Abstract Effect of Human Bone Marrow Mesenchymal Stromal Cells on Cytokine Production by Peripheral Blood Naive, Memory and Effector T Cells Researchers investigated the effect of human bone marrow mesenchymal stromal cells on naturally occurring peripheral blood functional compartments of CD4+ and CD8+ T cells: naive, central memory, effector memory and effector compartments. [Stem Cell Res Ther] Abstract | Full Article STAT3 Signaling Contributes to the High Effector Activities of Interleukin-15-Derived Dendritic Cells Analyses of surface molecules by flow cytometry and quantitative RNA profiling revealed differences between dendritic cells (DCs) derived from interleukin-4 (IL-4) versus IL-15 signaling, yet both lineages of DCs exhibited similar levels of surface molecules key to immune activation. [Immunol Cell Biol] Full Article The Galectin-9/Tim-3 Pathway Is Involved in the Regulation of NK Cell Function at the Maternal-Fetal Interface in Early Pregnancy Researchers demonstrate that the inhibitory molecule T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) is expressed on over 60% of decidual natural killer (NK) cells. [Cell Mol Immunol] Abstract Increased Proportion of FoxP3+ Regulatory T Cells in Tumor Infiltrating Lymphocytes Is Associated with Tumor Recurrence and Reduced Survival in Patients with Glioblastoma In order to assess whether FoxP3 was an independent driver differentially expressed in primary versus recurrent glioblastoma multiformes (GBMs), scientists stained resected primary and recurrent GBM tumors for CD3, CD4, CD8 and FoxP3 expression using standard immunohistochemistry. [Cancer Immunol Immunother] Abstract Comparison of Circulating and Intratumoral Regulatory T Cells in Patients with Renal Cell Carcinoma Investigators characterized the phenotype and function of circulating and intratumoral regulatory T cells of renal cell carcinoma patients in order to evaluate their implication in the inhibition of the local antitumor immune response. [Tumor Biol] Abstract Myeloid Derived Suppressor Cell Infiltration of Murine and Human Gliomas Is Associated with Reduction of Tumor Infiltrating Lymphocytes Scientists evaluated whether myeloid derived suppressor cells (MDSCs) infiltrate human GBM tissues, and whether a commonly used mouse model of GBM reproduces the biology of MDSCs that is observed in patients. [J Neurooncol] Abstract Engineered Dendritic Cells from Cord Blood and Adult Blood Accelerate Effector T Cell Immune Reconstitution against HCMV Researchers induced self-differentiation of peripheral blood and cord blood monocytes into dendritic cells processing pp65 (SmyleDCpp65). In vitro, SmyleDCpp65 resisted human cytomegalovirus (HCMV) infection, activated CD4+ and CD8+ T cells and expanded functional pp65-specific memory cytotoxic T lymphocytes. [Mol Ther Methods Clin Dev] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |