Evaluation of the Immunomodulatory Effect of Melatonin on the T-Cell Response in Peripheral Blood from Systemic Lupus Erythematosus Patients Investigators analyzed the role of in vitro administered melatonin in the immune response of peripheral leukocytes from treated systemic lupus erythematosus patients and age- and sex-matched healthy controls. [J Pineal Res] Abstract Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer Scientists identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs consist of both immature myeloid-derived suppressor cells and mature cells that are derived from high-density neutrophils in a TGF-β-dependent mechanism. [Cell Rep] Full Article | Graphical Abstract | Press Release MicroRNA-125b Modulates Inflammatory Chemokine CCL4 Expression in Immune Cells and Its Reduction Causes CCL4 Increase with Age Researchers report the role of microRNA-125b in regulating inflammatory CC chemokine 4 (CCL4) expression in human immune cells and its altered expression with aging. They observed that monocytes and naïve CD8 T cells expressed higher levels of CCL4 and exhibited an age-related increase in CCL4. [Aging Cell] Full Article DNA Methyltransferase Inhibition Accelerates the Immunomodulation and Migration of Human Mesenchymal Stem Cells Scientists treated human mesenchymal stem cells with 5-azacytidine, a DNA methyltransferase inhibitor, and confirmed that the inhibitory effects on mononuclear cell proliferation and cell migration toward activated T cells were increased. [Sci Rep] Full Article Serum Macrophage-Derived Chemokine/CCL22 Levels Are Associated with Glioma Risk, CD4 T Cell Lymphopenia and Survival Time Investigators measured peripheral CCL22, a dendritic cell/macrophage derived T cell trafficking chemokine, in sera from 1,208 glioma cases and 976 controls to assess whether it might provide a biomarker of glioma risk, survival, and immune dysfunction. [Int J Cancer] Abstract Clinical Outcomes of a Novel Therapeutic Vaccine with Tax Peptide-Pulsed Dendritic Cells for Adult T Cell Leukemia/Lymphoma in a Pilot Study Researchers developed a novel therapeutic vaccine designed to augment an human T cell leukemia virus type-I Tax-specific cytotoxic T lymphocyte response that has been implicated in anti-adult T cell leukemia/lymphoma effects, and conducted a pilot study to investigate its safety and efficacy. [Br J Haematol] Abstract Anti-Inflammatory T-Cell Shift in Neuropathic Pain Researchers investigated systemic T-cell subset responses and T-cell related cytokine profiles in patients with chronic neuropathic pain. They found a T helper 17 (TH17)/regulatory T-cell (Treg) imbalance with significantly increased anti-inflammatory Tregs and decreased pro-inflammatory TH17 cells in patients with neuropathic pain as compared to healthy controls. [J Neuroinflammation] Full Article Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem Cells Scientists determined whether human retinal pigment epithelial cells (RPE) from induced pluripotent stem (iPS) cells can inhibit T-cell activation in vitro. The cultured iPS-RPE cells inhibited cell proliferation and the production of IFN-γ by activated CD4+ T cells. [Invest Ophthalmol Vis Sci] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |