Timely and Spatially Regulated Maturation of B and T Cell Repertoire during Human Fetal Development Researchers analyzed levels of T cell receptor excision circles, signal-joint κ receptor excision circles, and intron recombination signal sequence-K-deleting element rearrangement, and T and B lymphocyte repertoire clonality in human fetuses from 12 to 26 weeks of gestational age. [Sci Transl Med] Abstract | Press Release Developing In Vitro Expanded CD45RA+ Regulatory T Cells as an Adoptive Cell Therapy for Crohn’s Disease To define the optimum population for regulatory T (Treg) cell therapy in Crohn’s disease, CD4+CD25+CD127loCD45RA+ and CD4+CD25+CD127loCD45RA− Treg subsets were isolated from patients’ blood and expanded in vitro using a workflow that can be readily transferred to a good manufacturing practice background. [Gut] Full Article Beyond Immune Density: Critical Role of Spatial Heterogeneity in Estrogen Receptor-Negative Breast Cancer Investigators combined automated histological image processing with methods of spatial statistics used in ecological data analysis to quantify spatial heterogeneity in the distribution patterns of tumor-infiltrating lymphocytes. [Mod Pathol] Abstract | Press Release Viral Entry Route Determines How Human Plasmacytoid Dendritic Cells Produce Type I Interferons Scientists showed that replication of the yellow fever live vaccine YF-17D in human plasmacytoid dendritic cells (pDCs) and pDC-like cell lines stimulated type I interferon production through RIG-I (retinoic acid-inducible gene I), a member of the RIG-I-like receptor family of cytosolic pattern recognition receptors. [Sci Signal] Abstract Inhibiting STAT5 by the BET Bromodomain Inhibitor JQ1 Disrupts Human Dendritic Cell Maturation Scientists investigated the effect of STAT5 inhibition on LPS-induced maturation of human monocyte-derived dendritic cells (Mo-DCs). They inhibited STAT5 by treating Mo-DCs with JQ1, a selective inhibitor of BET epigenetic readers, which can suppress STAT5 function. [J Immunol] Abstract Ex Vivo Peptide-MHC II Tetramer Analysis Reveals Distinct End-Differentiation Patterns of Human Pertussis-Specific CD4+ T Cells following Clinical Infection P.69 Pertactin (P.69 Prn)7–24 peptide-MHC II tetramers were designed to ex vivo interrogate the presence and differentiation state of P.69 Prn7–24 specific CD4+ T cells in six symptomatic pertussis cases. [Clin Immunol] Abstract T Cell Subsets in Human Airways Prior to and following Endobronchial Administration of Endotoxin Researchers investigated the distributions of T-cell subsets in the human airways and sought to determine whether pro- and anti-inflammatory T cells are involved in the local immune response to lung inflammation. [Respirology] Abstract PD-1 Expression Defines Two Distinct T-Cell Sub-Populations in Follicular Lymphoma that Differentially Impact Patient Survival To determine the biological and clinical relevance of programmed death 1 (PD-1) in follicular lymphoma, investigators characterized PD-1+ T-cell subsets and assessed their biological function as well as potential clinical impact. [Blood Cancer J] Full Article Reslizumab for Inadequately Controlled Asthma with Elevated Blood Eosinophil Counts: Results from Two Multicenter, Parallel, Double-Blind, Randomized, Placebo-Controlled, Phase III Trials Reslizumab is a humanized anti-interleukin 5 monoclonal antibody that disrupts eosinophil maturation and promotes programmed cell death. Investigators assessed the efficacy and safety of reslizumab in patients with inadequately controlled, moderate-to-severe asthma. [Lancet Respir Med] Abstract | Press Release Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |