Human Immunology News Volume 3.35 | Sep 8 2015

Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney
Researchers phenotypically and functionally characterized murine kidney CD4⁻CD8⁻ (double-negative; DN) T cells in the steady state and in response to ischemia-reperfusion injury. DN T cells also made up a large fraction of the T cell compartment in human kidneys. [J Am Soc Nephrol] Abstract

IL-11 Induces Differentiation of Myeloid-Derived Suppressor Cells through Activation of STAT3 Signaling Pathway
Scientists found that CD11b⁺CD14⁺ monocytic myeloid-derived suppressor cells were generated from peripheral blood mononuclear cells (PBMCs) of healthy donors in the presence of interleukin (IL)-11. IL-11-conditioned PBMCs induced higher expression of immunosuppressive molecules such as arginase-1. [Sci Rep] Full Article

Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors
T cells from primary tumor and blood of sixteen patients with pancreatic cancer were characterized by deep sequencing. By analyzing the complementary determining region 3 gene sequence, investigators found no significant differences in the T cell receptor repertoires between patients and healthy controls. [Sci Rep] Full Article

Low Marginal Zone-Like B Lymphocytes and Natural Antibodies Characterize Skewed B-Lymphocyte Subpopulations in del22q11 diGeorge Patients
The authors characterized the B-cell compartment in diGeorge syndrome patients. They observed a significantly increased number of naive B-cells and decreased number of switched memory B-cells in diGeorge patients. [Clin Immunol] Abstract

Effects of Aging on Human Leukocytes (Part II): Immunophenotyping of Adaptive Immune B and T Cell Subsets
Scientists investigated alterations in the subpopulations of the B and T cells among 24 healthy young and 26 healthy elderly individuals. γδTCR⁺ T cells were overall decreased, while CD4⁺CD8⁻ cells among γδTCR⁺ T cells were increased in the elderly. [Age] Abstract

Vaccination Expands Antigen-Specific CD4⁺ Memory T Cells and Mobilizes Bystander Central Memory T Cells
The authors showed in healthy volunteers that a booster vaccination with tetanus toxoid (TT) expanded peripheral blood TT-specific CD4⁺ T helper memory (Th_mem) cells as expected, but was accompanied by parallel increase of Th_mem cells specific for two unrelated and non cross-reactive common recall antigens. In a new cohort of healthy human subjects, they compared blood vaccine-specific and bystander Th_mem cells in terms of differentiation stage, function, activation and proliferative status. [PLoS One] Full Article

Low HIP1R mRNA and Protein Expression Are Associated with Worse Survival in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP
Researchers have previously shown that low HIP1R protein expression was associated with poorer survival in diffuse large B-cell lymphoma patients from Denmark treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). They extended these findings and validated the prognostic and subtyping utility of HIP1R expression at both transcript and protein level. [Exp Mol Pathol] Abstract

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OBI Pharma to Unblind Its Phase II/III Clinical Trial of OBI-822 Active Immunotherapy for Metastatic Breast Cancer by March 2016
OBI Pharma, Inc. announced it plans to unblind its flagship OBI-822/821 Phase II/III clinical trial by March 2016. [OBI Pharma, Inc.] Press Release

Glenmark’s Novel Monoclonal Antibody GBR 830 to Enter Phase II Clinical Studies in Atopic Dermatitis and Celiac Disease in US and Europe
Glenmark Pharmaceuticals S.A announced that GBR 830, a novel monoclonal antibody, has completed clinical Phase I dosing. GBR 830 is an antagonist of OX40, a costimulatory receptor expressed on T cells mediating T cell activation and survival. [Glenmark Pharmaceuticals S.A] Press Release

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