Cancer Mediates Effector T Cell Dysfunction by Targeting MicroRNAs and EZH2 via Glycolysis Restriction Researchers found that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintaining high expression of microRNAs miR-101 and miR-26a, which constrained expression of the methyltransferase EZH2. [Nat Immunol] Abstract | Press Release Human Caspase-4 and Caspase-5 Regulate the One-Step Non-Canonical Inflammasome Activation in Monocytes The authors report that caspase-4 and caspase-5 mediate IL-1α and IL-1β release from human monocytes after lipopolysaccharide stimulation. [Nat Commun] Full Article Crohn’s Disease-Derived Monocytes Fail to Induce Paneth Cell Defensins Using cultures of human ileal tissue, investigators showed that the secretome of peripheral blood mononuclear cells from healthy controls restored the attenuated Paneth cell α-defensin expression characteristic of patients with ileal Crohn’s disease. [Proc Natl Acad Sci USA] Abstract | Full Article Ubiquitin-Dependent Endocytosis of NKG2D-DAP10 Receptor Complexes Activates Signaling and Functions in Human NK Cells In experiments with human NK cells and cell lines, researchers found that the ligand-induced endocytosis of NK receptor group 2, member D (NKG2D)-DNAX-activating protein 10 (DAP10) depended on the ubiquitylation of DAP10, which was also required for degradation of the internalized complexes. [Sci Signal] Abstract Impact of the Inflammatory Microenvironment on T-Cell Phenotype in the Progression from Reflux Esophagitis to Barrett Esophagus and Esophageal Adenocarcinoma Previous studies have examined the secreted cytokines from esophageal tissue during disease progression but this study is the first to examine the activation phenotype and the inflammatory profile of CD4+ and CD8+ T-cells in human esophagitis, Barrett esophagus and esophageal adenocarcinoma tissue. [Cancer Lett] Abstract Interferon Gamma Boosts the Nucleotide Oligomerization Domain 2-Mediated Signaling Pathway in Human Dendritic Cells in an X-Linked Inhibitor of Apoptosis Protein and Mammalian Target of Rapamycin-Dependent Manner Because the simultaneous presence of various microbial products and cytokines in inflamed tissues modulates dendritic cell (DC) function, scientists examined how interferon gamma, a central modulator of inflammation, affects the nucleotide oligomerization domain 2-mediated signaling pathway in human conventional DCs. [Cell Mol Immunol] Abstract Enhancement of Regulatory T Cell-Like Suppressive Function in MT-2 by Long-Term and Low-Dose Exposure to Asbestos The effects of continuous exposure of regulatory T cells (Treg) to asbestos were examined using the human T-lymphotropic virus-1 immortalized human T cell line MT-2, which possesses a suppressive function and expresses the Treg marker protein, Foxp3. [Toxicology] Abstract Rhinovirus Stimulated IFN-α Production: How Important Are Plasmacytoid DCs, Monocytes and Endosomal pH? Investigators demonstrated that, using intracellular flow cytometry, >90% of the IFN-α-producing cells in human blood mononuclear cells following human rhinovirus 16 exposure are plasmacytoid dendritic cells, whereas monocytes and myeloid dendritic cells contribute only 10% and <1%, respectively, of the IFN-α production. [Clin Transl Immunol] Full Article Expression Analysis of Surface Molecules on Human Thymic Dendritic Cells with the 10th HLDA Workshop Antibody Panel Scientists studied the binding of 71 monoclonal antibodies submitted to the HLDA10 workshop to human CD123+ plasmacytoid dendritic cells (DC) and the two subsets of conventional DC isolated from thymus tissue of infants undergoing corrective heart surgery. [Clin Transl Immunol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |