A Validated Gene Regulatory Network and GWAS Identifies Early Regulators of T Cell–Associated Diseases Researchers identified early regulators of T cell–mediated disease by finding transcription factors involved in T cell differentiation that are enriched in disease-associated polymorphisms. [Sci Transl Med] Abstract IL-36α: A Novel Cytokine Involved in the Catabolic and Inflammatory Response in Chondrocytes OA chondrocytes expressed more IL-36α than healthy chondrocytes. Immune cells infiltrated into the joint and PBMCs expressed higher levels of IL-36α in comparison to chondrocytes. [Sci Rep] Full Article Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration The authors previously showed that, when peripheral blood mononuclear cells (PBMCs) were stressed with ionizing radiation, they released paracrine factors that showed regenerative capacity in vitro and in vivo. In this study, they aimed to characterize the secretome of PBMCs and to investigate its biologically active components in vitro and in vivo. [Sci Rep] Full Article CD40 Ligand-Expressing Recombinant Vaccinia Virus (rVV40L) Promotes the Generation of CD8+ Central Memory T Cells Scientists generated a replication incompetent CD40 ligand-expressing recombinant vaccinia virus to promote the differentiation of human naïve CD8+ T cells into central memory CD8+ T cells specific for viral and tumor associated antigens. [Eur J Immunol] Abstract Combination of Cytokine-Induced Killer and Dendritic Cells Pulsed with Antigenic α-1,3-Galactosyl Epitope–Enhanced Lymphoma Cell Membrane for Effective B-Cell Lymphoma Immunotherapy Incubation of processed cell membranes with autologous dendritic cells (DCs) in the presence of human serum containing abundant natural anti–α-1,3-galactosyl immunoglobulin G led to the effective phagocytosis of tumor membranes by DCs. [Cytotherapy] Abstract miR-27a and miR-214 Exert Opposite Regulatory Roles in Th17 Differentiation via Mediating Different Signaling Pathways in Peripheral Blood CD4+ T Lymphocytes of Patients with Relapsing–Remitting Multiple Sclerosis Researchers assessed transcript levels of miR-27a and miR-214, in purified CD4+ T cells of multiple sclerosis patients, during relapsing and remitting phases in inducing differentiation of T naïve cells to T helper 17 (Th17) cells. [Immunogenetics] Abstract Profiling of Primary Peripheral Blood- and Monocyte-Derived Dendritic Cells Using Monoclonal Antibodies from the HLDA10 Workshop in Wollongong, Australia Scientists compared the reactivity patterns of HLDA10 antibodies with plasmacytoid dendritic cells (DCs), CD1c+ DCs and CD141+ DCs, as well as with CD14+-derived monocyte-derived DCs cultured for seven days in the presence of granulocyte–macrophage colony-stimulating factor plus interleukin-4. [Clin Transl Immunol] Full Article Myeloid Cells as Target of Fingolimod Action in Multiple Sclerosis In vitro and ex vivo immunologic studies coupled with flow cytometry were performed to evaluate the action of fingolimod on lipopolysaccharide–induced expression of activation markers in human monocytes from healthy participants, participants with untreated multiple sclerosis (MS), and participants with fingolimod-treated MS. [Neuroimmunol Neuroinflamm] Full Article | Editorial Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |