FOXP3 Can Modulate TAL1 Transcriptional Activity through Interaction with LMO2 The authors showed that increased forkhead box P3 (FOXP3) levels negatively correlate with expression of genes regulated by the oncogenic T-cell acute lymphocytic leukemia 1 (TAL1)-complex in human T-cell acute lymphoblastic leukemia (T-ALL) patient samples as well as a T-ALL cell line ectopically expressing FOXP3. [Oncogene] Abstract Antibody Induced CD4 Down-Modulation of T Cells Is Site-Specifically Mediated by CD64+ Cells Treatment of PBMC with the CD4-specific monoclonal antibody BT-061 induces CD4 down-modulation of T cells. Scientists report that addition of BT-061 to purified T cells did not confer this effect, whereas incubation of T cells in BT-061 coated wells restored CD4 down-modulation. [Sci Rep] Full Article Accumulation Mechanisms of CD4+CD25+FOXP3+ Regulatory T Cells in EBV-Associated Gastric Carcinoma Because regulatory T cells (Tregs) are regarded as a critical hurdle in anti-tumour immunity, researchers assessed the distribution of Tregs in 45 cases of Epstein-Barr virus (EBV)-associated gastric carcinomas and 45 cases of EBV-negative gastric carcinoma with matched clinicopathological parameters by immunohistochemistry. [Sci Rep] Full Article Identification of a Novel Mechanism of Action of Fingolimod (FTY720) on Human Effector T Cell Function through TCF-1 Upregulation Researchers determined the effect of FTY720 on human T cell activation and effector function. They showed that FTY720 treatment not only affects T cell trafficking but also T cell activation. [J Neuroinflammation] Full Article LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production The authors investigated the gene expression profile of all-trans retinoic acid (ATRA)–treated human CD4+ T cells. Leucine zipper transcription factor-like 1 (LZTFL1) was upregulated by ATRA in a dose- and time-dependent manner. [J Immunol] Abstract The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation Researchers report the identification of human DLL4+ dendritic cells (DCs) and their critical role in regulating Th1 and Th17 differentiation. CD1c+ DCs and plasmacytoid DCs from the peripheral blood of healthy donors did not express DLL4. [J Immunol] Abstract Human Regulatory T Cells Control TCR Signaling and Susceptibility to Suppression in CD4+ T Cells Scientists demonstrated that T cell receptors and costimulation are required to activate the regulatory T cell suppressive function. Regulatory T cells suppressed the T cell receptor signaling in effector T cells in a time-dependent manner that corresponded with inhibition of cytokine production and proliferation. [J Leukoc Biol] Abstract Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-Cell Subtype in Adult T-Cell Leukemia The authors focus on the functional and clinical relationship between the epigenetic pattern of the Treg-specific demethylated region (TSDR) and adult T-cell leukemia (ATL). Analysis of DNA methylation in specimens from 26 ATL patients showed that 15 patients hypomethylated the TSDR. [Cancer Immunol Res] Abstract Association of Depressed Anti-HER2 T-Helper Type 1 Response with Recurrence in Patients with Completely Treated HER2-Positive Breast Cancer Investigators determined whether circulating anti-human epidermal growth factor receptor 2 (HER2) CD4-positive T-helper type 1 immunity correlates with recurrence in patients with completely treated HER2-positive invasive breast cancer. [JAMA Oncol] Abstract | Press Release Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |