Human Immunology News 4.21 May 31, 2016 | |
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TOP STORYInvestigators analyzed cytogenetic data from 427 children with relapsed B-cell precursor ALL treated on the international trial, ALLR. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists provide a strategy for deriving large numbers of clinical-grade tumor-redirected T memory stem cells starting from naïve precursors. [Blood] Abstract Researchers performed a two-cohort, Phase I safety and immunogenicity study of IMA950 in addition to standard chemo-radiotherapy and adjuvant temozolomide in patients with newly diagnosed glioblastoma. [Clin Cancer Res] Abstract Investigators initiated a study of healthy women to characterize resident T cell populations in the lower female genital tract from lavage and patient-matched peripheral blood to investigate potential mechanisms of HIV sexual transmission. [J Immunol] Abstract Scientists provide evidence that IL-21, a cytokine produced during chronic inflammation or infectious diseases, promotes the differentiation of a specific subset of NK cells coexpressing CD86 and HLA-DR and lacking NKp44. [J Immunol] Abstract Prognostic Impact of High Levels of Circulating Plasmacytoid Dendritic Cells in Breast Cancer Investigators phenotyped circulating plasmacytoid dendritic cells, myeloid-derived suppressor cells and regulatory T-cells in relation to T-cell responses to Her-2 in vitro in 75 untreated breast cancer patients 28-87 years of age at diagnosis. [J Transl Med] Full Article The BD-FACSPresto™ CD4 is a new, point-of-care instrument utilizing finger-stick capillary blood sampling. Researchers evaluated its performance against predicate CD4 testing in South Africa. [PLoS One] Full Article A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells Scientists showed that ex vivo expansion of low purity magnetic bead isolated regulatory T cells (Treg) in the presence of a TNFR2 agonist monoclonal antibody together with rapamycin, results in a homogenous stable suppressive Treg population that expresses FOXP3 and Helios, shows low expression of CD127 and hypo-methylation of the FOXP3 gene. [PLoS One] Full Article Investigators evaluated the prognostic value of beta-2 microglobulin (B2MG) and proposed a new prognostic model including B2MG for patients with diffuse large B-cell lymphoma. [Hematol Oncol] Abstract Researchers developed a novel in vitro system for generation of stable 15Rα/15 complexes. Immunologically quantifiable amounts of IL-15 were obtained when both IL-15Rα and IL-15 genes were co-transduced in NIH 3T3 fibroblast based artificial antigen presenting cells expressing human HLA A:0201, β2 microglobulin, CD80 and CD54 and a murine pro-B cell line. [Clin Exp Immunol] Abstract Subscribe to out sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSDevelopmental Origins of Inflammatory and Immune Diseases The authors show the results from human and different animal species and highlight the underlying mechanisms, including damaged development of cells in the thymus, helper T cell 1/ helper T cell 2 balance disturbance, abnormal epigenetic modification, effects of maternal glucocorticoid overexposure on fetal lymphocytes and effects of the fetal hypothalamic-pituitary-adrenal axis on the immune system. [Mol Hum Reprod] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field.
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INDUSTRY NEWSComprehensive Collaboration Agreement between Osaka University and Chugai Osaka University and Chugai Pharmaceutical Co., Ltd. announced the conclusion of a comprehensive collaboration agreement for advanced research in immunology between the Osaka University Immunology Frontier Research Center and Chugai. [Osaka University] Press Release New International Initiative Will Focus on Immunology Research and Treatments University of California San Diego School of Medicine and Chiba University School of Medicine in Japan have announced a new collaborative research center to investigate the most promising aspects of immunology, especially the area of mucosal immunology, and to speed development of clinical applications. [University of California San Diego School] Press Release | |
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EVENTSNEW 7th HIV & Aging Workshop 2016 Visit our events page to see a complete list of events in the human immunology community.
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