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Pulmonary Cell News| Human Immunology News 4.32 August 16, 2016 | |
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TOP STORYImproving the Efficacy and Safety of Biologic Drugs with Tolerogenic Nanoparticles Researchers demonstrated that poly(lactic-co-glycolic acid) nanoparticles carrying rapamycin, but not free rapamycin, are capable of inducing durable immunological tolerance to co-administered proteins that is characterized by the induction of tolerogenic dendritic cells, an increase in regulatory T cells, a reduction in B cell activation and germinal center formation, and the inhibition of antigen-specific hypersensitivity reactions. [Nat Nanotechnol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators defined the phenotype and transcriptional program of a subset of antigen-specific B cells, which they have called ‘activated B cells’, that were distinct from antibody-secreting cells and were committed to the memory B cell lineage. [Nat Immunol] Abstract | Press Release Tumor Immune Profiling Predicts Response to Anti-PD-1 Therapy in Human Melanoma Increasing fractions of programmed cell death 1 high/cytotoxic T lymphocyte-associated protein 4 high (PD-1hiCTLA-4hi) cells within the tumor-infiltrating CD8+ T cell subset strongly correlated with response to therapy and progression-free survival. Functional analysis of these cells revealed a partially exhausted T cell phenotype. [J Clin Invest] Full Article Lymphatic Vessels Regulate Immune Microenvironments in Human and Murine Melanoma The authors examined the contribution of lymphatic drainage to tumor inflammation and immunity using a mouse model that lacks dermal lymphatic vessels. Melanomas implanted in these mice grew robustly, but exhibited drastically reduced cytokine expression and leukocyte infiltration compared with those implanted in control animals. [J Clin Invest] Full Article Exogenous TNFR2 Activation Protects From Acute GvHD via Host T reg Cell Expansion The authors present a novel strategy for inhibiting graft-versus-host disease (GvHD) that is based on the in vivo expansion of recipient regulatory T (T reg) cells before allogeneic hematopoietic stem cell transplantation, exploiting the crucial role of tumor necrosis factor receptor 2 (TNFR2) in T reg cell biology. [J Exp Med] Abstract | Press Release Measuring the Immune System: A Comprehensive Approach for the Analysis of Immune Functions in Humans Scientists demonstrated an approach which provides information about total number of leukocytes, detailed quantitative and qualitative changes in the composition of lymphocyte subsets, cytokine levels in serum and functional properties of T cells, NK cells and monocytes. Using samples from a cohort of 24 healthy volunteers, they demonstrated the feasibility of our approach to detect changes in immune functions. [Arch Toxicol] Abstract Scientists tested the hypothesis that intratumoral administration of IFNγ will induce CXCL9-11 and will induce T cell recruitment and anti-tumor immune signatures in melanoma metastases. [Cancer Immunol Immunother] Abstract Researchers retrospectively analyzed samples and other data from 144 patients with diffuse large B cell lymphoma who were newly diagnosed in our institution and treated with standard R-CHOP therapy. [Cancer Immunol Immunother] Abstract Switching CAR T Cells On and Off: A Novel Modular Platform for Retargeting of T Cells to AML Blasts Researchers describe a novel modular universal chimeric antigen receptor engineered (CAR T) platform technology termed UniCAR that reduces the risk of on-target side effects by a rapid and reversible control of CAR T-cell reactivity. [Blood Cancer J] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSRegulatory Circuits of T Cell Function in Cancer The authors discuss T cell-intrinsic molecular alterations and metabolic communication in the tumor microenvironment. Identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy. [Nat Rev Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSCatalent Biologics and Zumutor Collaborate to Develop Antibodies with Enhanced ADCC Activity Catalent Pharma Solutions and Zumutor Biologics Inc. announced a successful research study, combining Catalent’s proprietary GPEx® technology and Zumutor’s fucose knockout platform, to create new and more efficacious antibodies. [Catalent Pharma Solutions] Press Release KalVista Pharmaceuticals announced the dosing of the first subject in a first-in-human clinical trial to evaluate the safety, pharmacokinetics and pharmacodynamics of orally delivered KVD818 in healthy volunteers. [KalVista Pharmaceuticals] Press Release Xycrobe Announces Research Collaboration with Johnson & Johnson Innovation Xycrobe Therapeutics announced that it has entered into a research agreement with Johnson & Johnson Consumer, Inc. The collaboration, facilitated by Johnson & Johnson Innovation, is focused on further understanding applications of Xycrobe’s platform technology developed for the treatment of inflammatory skin diseases. [Xycrobe Therapeutics (PR Newswire Association LLC.)] Press Release Vyriad announced the signing of a license collaboration agreement with Imanis Life Sciences to develop in vitro and in vivo theranostic tests that assess the probability that a cancer patient will be responsive to Vyriad’s oncolytic virus therapeutics. [Vyriad] Press Release XTL Biopharmaceuticals Announces New Patent Filing in U.S. for Lupus Drug hCDR1 XTL Biopharmaceuticals Ltd. announced that it has filed a new patent application with the U.S. Patent and Trademark Office to protect doses of hCDR1 lower than 0.5 mg weekly, in the treatment of Systemic Lupus Erythematosus. [XTL Biopharmaceuticals Ltd.] Press Release Novartis announced that six scientists will receive the 2016 Novartis Prizes for Immunology at the upcoming 16th International Congress of Immunology in Melbourne, Australia. [XNovartis] Press Release | |
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POLICY NEWSEMA Adopts New Biologic, Biosimilar Pharmacovigilance Guidance The European Medicines Agency (EMA) announced new recommendations for monitoring the safety of biologics and biosimilars. The guidance will take effect on 16 August 2016. [Regulatory Affairs Professionals Society] Editorial | Guideline A Tale of Two Governments: The Politician Behind Argentina’s Science Growth Lino Barañao, the only minister to stay in power after last year’s elections, lays out his plans. [Nature News] Editorial Spiking Genomic Databases with Misinformation Could Protect Patient Privacy Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News] Editorial UK Government Gives Brexit Science Funding Guarantee British scientists say they’re relieved by a government promise to guarantee them funding for existing EU research projects, even after the country leaves the European Union. But the reassurance only partly allays concerns about Brexit’s effect on UK science. [Nature News] Editorial Candidate Cancer Drug Suspected After Death of Three Patients at an Alternative Medicine Clinic A new type of cancer drug developed at Johns Hopkins University in Baltimore, Maryland, but not yet tested in clinical trials may have triggered the deaths of three patients who were undergoing an alternative cancer treatment by a nonmedical practitioner in Germany. [ScienceInsider] Editorial
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EVENTSNEW 2016 Australasian HIV & AIDS Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Immunology (Vanderbilt University Medical Center) NEW Postdoctoral Fellow – Mucosal Immunology (University of Utah) NEW Postdoctoral Fellow – Metastatic Breast Cancer (Purdue Center for Cancer Research) Technical Sales Representative (STEMCELL Technologies Inc.) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Assistant Associate – Cancer Immunology (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – CRISPR/Cas9 Screens in Immune Cells (Wellcome Trust Sanger Institute) Postdoctoral Research Associate – Immunology (Benaroya Research Institute at Virginia Mason) Postdoctoral Position – Immunology (Ludwig-Maximilians-Universität) Postdoctoral Fellow – Cancer Biology and Cancer Immunology (Fox Chase Cancer Center) Postdoctoral Position – Mucosal Immunology (KU Leuven) Postdoctoral Scientist – Immune Focused In Vitro Research (Celentyx Ltd) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Human Immunology News Volume 4.32 | Aug 16 2016
