Human Immunology News 4.41 October 18, 2016 | |
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TOP STORYL-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-Tumor Activity Using high-resolution mass spectrometry, researchers generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. They discovered critical changes in the arginine metabolism that led to a drop in intracellular L-arginine concentration. [Cell] Full Article | Graphical Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers prospectively analyzed HSC graft content in CD34+, NK, conventional T, regulatory T and invariant NKT cells in 117 adult patients before allogeneic hematopoietic stem cell transplantation. [Leukemia] Abstract Scientists used immunohistochemistry to characterize immune infiltration in 184 breast cancer samples, of which 65 were within the DNA damage response–deficient (DDRD) subtype. Isogenic cell lines, which represent DDRD-positive and -negative, were used to study the effects of chemokine release on peripheral blood mononuclear cell migration and the mechanism of immune signaling activation. [J Natl Cancer Inst] Full Article For most patients experiencing partial transverse myelitis, plasmablasts are elevated in the blood at the first clinical presentation of disease. In this study scientists found that many of these peripheral plasmablasts are autoreactive and recognize primarily gray matter targets in brain tissue. [Acta Neuropathol] Abstract Both the human αCD11a antibody-drug conjugate (ADC) and a mouse surrogate αCD11a ADC rapidly internalized into immune cells and suppressed LPS-induced TNFα secretion in primary human monocytes and mouse peritoneal cells, respectively. [Mol Ther] Abstract Scientists identified that high glucose induced the activation of the NLRP3-ASC inflammasome, leading to caspase-1 activation, and IL-1β and IL-18 secretion in human monocytic cell lines. [Sci Rep] Full Article Functionally different isoforms are generated by alternative splicing at exons 7–9 and exon 13 giving rise to BC1, BC2, C1 and C2. Researchers developed a novel real-time PCR assay that allows quantitative comparisons between these isoforms. Their relative frequency in CD4+ T cells from 100 donors revealed a distribution with high interpersonally variability. [Sci Rep] Full Article A successful trial with rituximab suggests an additive role for B cells in the pathogenesis. Therefore, the authors studied B cell abnormalities in Behçet’s disease patients and the effect of TNF-blocking therapy. [Rheumatology (Oxford)] Abstract To confirm the hypothesis that malignant tumors escape from the host immune system during metastasis, investigators evaluated the percentage of tumor-infiltrating lymphocytes in paired samples of primary and metastatic breast tumors. [Cancer Sci] Abstract Investigators analyzed the number of tumor infiltrating lymphocytes by flow cytometry in diagnostic biopsies from 96 Hodgkin lymphoma homogeneously treated patients with ABVD with or without radiotherapy. Most lymph node cells were lymphocytes, with a median T/B/NK distribution of 74%/26%/0.7%, and CD4+ T-cell predominance. [Leuk Lymphoma] Abstract To investigate the underlying mechanisms involved in suppressing or promoting CD8+ T cell functions, the authors focused on interleukin 10 (IL-10), a pleiotropic cytokine with controversial roles in antitumor immunity. They found that compared to healthy controls, circulating CD8+ T cells in HPV 16-infected cervical cancer patients expressed significantly higher levels of IL-10. [Tumor Biol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSRare Phenotypes in the Understanding of Autoimmunity The authors discuss selected examples of past and recent investigations into rare phenotypes of autoimmunity that have delineated pathways critical for central and peripheral control of the adaptive immune system. They outline the implications of these findings for rare and common forms of autoimmunity and will discuss the benefits and potential pitfalls of the integration of next-generation sequencing into algorithms for clinical diagnostics. [Immunol Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSAdaptimmune Therapeutics plc announced that its amended protocol using its NY-ESO SPEAR® (Specific Peptide Enhanced Affinity Receptor) T-cell therapy in ovarian cancer patients with treatment resistant or refractory metastatic ovarian cancer is now actively recruiting. [Adaptimmune Therapeutics plc] Press Release CStone Pharmaceuticals’ PD-L1 Monoclonal Antibody IND Has been Formally Accepted by the CFDA CStone Pharmaceuticals announced that, following the successful site inspection by the Jiangsu FDA for its recombinant anti PD-L1 monoclonal antibody, the CFDA has recently accepted the submission of WBP3155’s IND. Wholly owned and independently developed by CStone Pharmaceuticals, WBP3155 is China’s first innovative, fully humanized, full length original format IgG monoclonal antibody drug candidate. [CStone Pharmaceuticals (PR Newswire Association LLC.)] Press Release Boehringer Ingelheim announced that it will join The Leukemia & Lymphoma Society in a groundbreaking, first-of-its-kind collaborative trial program to advance treatments for patients with acute myeloid leukemia. [Boehringer Ingelheim Pharmaceuticals] Press Release | |
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POLICY NEWSBiden’s Moonshot Cancer Plan Calls for More Data Sharing Vice President Joe Biden released his vision for doubling progress against cancer over 5 years. It includes numerous policy recommendations and a laundry list of projects by the National Cancer Institute and other federal agencies that would require additional funding. [Science Insider] Editorial U.S. and Cuban Biomedical Researchers are Free to Collaborate The U.S. Department of the Treasury has authorized U.S. scientists to freely collaborate with Cuban counterparts on everything from cancer therapies to combating the Zika virus. [Science Insider] Editorial
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JOB OPPORTUNITIESNEW Assistant Professor – Microbiology and Immunology (University of California, San Francisco) Postdoctoral Fellowship – Immunology (Brigham and Women’s Hospital) Principal Investigator – Immunology (Singapore Immunology Network) Postdoctoral Position – Immunology (Klinikum der Universität München) Faculty Positions – Immunology (Ohio State University) Research Associate – Cellular Therapy (California Institute for Biomedical Research) Postdoctoral Fellow – Molecular Immunology (University of California San Diego School of Medicine) Faculty Positions – Various Areas (Jackson Laboratory) Faculty Position – Immunology (Vanderbilt University Medical Center) Postdoctoral Fellow – Mucosal Immunology (University of Utah) Postdoctoral Fellow – Metastatic Breast Cancer (Purdue Center for Cancer Research) Assistant Associate – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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