Human Immunology News 5.01 January 10, 2017 | |
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TOP STORYThe authors investigated the magnitude, diversity, and specificity of alloreactive CD8 T cells in patients who developed graft-versus-leukemia (GVL) reactivity after donor lymphocyte infusion in the absence or presence of graft-versus-host disease (GVHD). They observed a lower magnitude and diversity of CD8 T cells for minor histocompatibility antigens in patients with selective GVL reactivity without GVHD. [J Clin Invest] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Inherited Human IRAK-1 Deficiency Selectively Impairs TLR Signaling in Fibroblasts The authors describe a boy with X-linked MECP2 deficiency-related syndrome due to a large de novo Xq28 chromosomal deletion encompassing both MECP2 and IRAK1. The IRAK-1 protein was completely absent from the patient’s fibroblasts, which responded very poorly to all TLR2/6, TLR1/2, and TLR4 agonists tested but had almost unimpaired responses to interleukin-1β. [Proc Natl Acad Sci USA] Abstract In the multicenter ZUMA-1 Phase I study, investigators evaluated KTE-C19, an autologous CD3ζ/CD28-based chimeric antigen receptor (CAR) T cell therapy, in patients with refractory diffuse large B cell lymphoma. [Mol Ther] Abstract | Press Release A 52-year-old female who was diagnosed as advanced unresectable/metastatic cholangiocarcinoma and resistant to the following chemotherapy and radiotherapy was treated with CART cocktail immunotherapy, which was composed of successive infusions of CART cells targeting epidermal growth factor receptor (EGFR) and CD133, respectively. [J Hematol Oncol] Abstract IFN Type I and II Induce BAFF Secretion from Human Decidual Stromal Cells Decidual stromal cells produced B cell activating factor (BAFF) when stimulated with IFN-γ and IFN-α, and NK cells and NK-T-like cells competent of IFN-γ production were isolated from the decidua. B cells at different maturational stages are present in decidua and all expressed BAFF-R, while stromal cells did not. [Sci Rep] Full Article The Plant Hormone Abscisic Acid Is a Pro-Survival Factor in Human and Murine Megakaryocytes Researchers investigated the role of exogenous abscisic acid in modulating thrombopoiesis, the process of platelet generation. They demonstrated that expression of both LANCL-2 and GRP78 is up-regulated during hematopoietic stem cell differentiation into mature megakaryocytes. [J Biol Chem] Abstract Researchers used a humanized mouse model, reconstituted with human peripheral blood mononuclear cells from seropositive donors, to illustrate the potential of three known antigens for boosting both T- and B-cell immune responses. [Immunology] Abstract Sitagliptin Inhibit Human Lymphocytes Proliferation and Th1/Th17 Differentiation In Vitro To investigate the direct effect of dipeptidyl peptidase-4 in immune response, human peripheral blood mononuclear cells from healthy volunteers were obtained by Ficoll gradient and cultivated in the absence or presence of phytohemagglutinin (PHA), or stimulated with PHA and treated with sitagliptin. [Eur J Pharm Sci] Abstract TGF-β3 Inhibits Antibody Production by Human B Cells The effect of TGF-β3 on human B cells has not been reported, and scientists examined the effect of TGF-β3 on human B cells. TGF-β3 suppressed B cell survival, proliferation, differentiation into plasmablasts, and antibody secretion. [PLoS One] Full Article Effects of Low-Level Laser Irradiation on Human Blood Lymphocytes In Vitro Scientists investigated whether low-level laser irradiation affected lymphocyte count in human whole blood in vitro. A total number of 130 blood samples were collected from apparently healthy adult patients through venipuncture into tubes containing EDTA. [Lasers Med Sci] Abstract Investigators describe the reproducible generation and phenotyping of human induced regulatory T cells from naïve CD4+ T cells in vitro. [J Vis Exp] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSMarkers and Function of Human NK Cells in Normal and Pathological Conditions A clear correlation exists between size of the alloreactive natural killer (NK) cell population and clinical outcome. Thus, in view of the recent major advances in cancer therapy based on immuno-mediated mechanisms, the phenotypic analysis of cells and molecules involved in these mechanisms plays an increasingly major role. [Int J Cardiol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSTG Therapeutics, Inc. announced that the U.S. Food and Drug Administration has granted orphan drug designation covering the combination of TG-1101, the company’s novel, glycoengineered anti-CD20 monoclonal antibody, and TGR-1202 the company’s oral, next generation PI3K delta inhibitor, for the treatment of patients with chronic lymphocytic leukemia. [TG Therapeutics, Inc.] Press Release Cellular Biomedicine Group Inc. announced the approval and commencement of patient enrollment in China for its CALL-1 Phase I clinical trial utilizing its optimized proprietary C-CAR011 construct of CD19 chimeric antigen receptor T-cell therapy for the treatment of patients with relapsed or refractory CD19+ B-cell acute lymphoblastic leukemia. [Cellular Biomedicine Group Inc.] Press Release Celyad announced that the U.S. Patent and Trade Office (USPTO) has decided to uphold Celyad’s U.S. Patent No. 9,181,527, relating to allogeneic human primary T-cells that are engineered to be TCR-deficient and express a CAR. [Celyad] Press Release Pure MHC to Partner with AbbVie on Oncology Research Emergent Technologies, Inc. announced that its target discovery portfolio company, Pure MHC, and global biopharmaceutical company, AbbVie, will embark on a research and license agreement to discover and validate peptide targets for use with T-cell receptor therapeutics in several types of cancers. [Emergent Technologies, Inc.] Press Release Kite Pharma and Shanghai Fosun Pharmaceutical (Group) Co., Ltd., announced a joint venture, Fosun Pharma Kite Biotechnology Co., Ltd., to develop, manufacture and commercialize axicabtagene ciloleucel in China with the option to include additional products, including two T cell receptor product candidates from Kite. [Kite Pharma] Press Release Amgen and Immatics Enter Strategic Collaboration to Develop Novel Bispecific Cancer Immunotherapies Amgen and Immatics Biotechnologies GmbH announced a research collaboration and exclusive license agreement to develop next-generation, T-cell engaging bispecific immunotherapies targeting multiple cancers. [Amgen] Press Release AbCellera Announces Multi-Target Research Collaboration with Pfizer AbCellera Biologics, Inc. announced a new therapeutic antibody discovery collaboration with Pfizer Inc. AbCellera will apply its proprietary monoclonal antibody screening platform to attempt to discover function-modulating antibodies against undisclosed membrane protein targets. [AbCellera Biologics, Inc.] Press Release | |
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POLICY NEWSBrexit Vote Drives UK Academics to Think about Leaving A survey of more than 1,000 UK-based university staff suggests that the country’s vote to leave the European Union could drive an academic exodus. [Nature News] Editorial FASEB Launches Survey on Shared Research Resources FASEB launched a survey of researchers’ experiences with shared research resources. [Federation of American Societies for Experimental Biology] Editorial
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JOB OPPORTUNITIESNEW Senior Scientist – Immunology (Immatics Biotechnologies GmbH) Postdoctoral Position – Visceral Pain and Neuro-Immune Interaction (KU Leuven) Scientist Positions – Immunology (New York Blood Center) PhD Student – Cancer Research (University of Otago) Postdoctoral Research Fellow – Melanoma (Dana-Farber Cancer Institute) Scientist/Senior Scientist – Immunology (Vor BioPharma) Postdoctoral Research Fellow – Immune Regeneration (Fred Hutchinson Cancer Research Center) Faculty Positions – Cancer Immunology (University of New Mexico) Postdoctoral Position – Immunology of HIV-1 and Cancer (University of Alabama at Birmingham) Postdoctoral Fellow – Molecular Immunology (University of California San Diego School of Medicine) Assistant Associate – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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