Human Immunology News 6.12 March 27, 2018 | |
| |
TOP STORYIkaros Family Zinc Finger 1 Regulates Dendritic Cell Development and Function in Humans Investigators showed that heterozygous mutation of Ikaros family zinc finger (IKZF1) in human decreased plasmacytoid dendritic cell (pDC) numbers and expanded conventional DC1 (cDC1). Lenalidomide, a drug that induces proteosomal degradation of IKZF1, also decreased pDC numbers in vivo, and reduced the ratio of pDC/cDC1 differentiated from progenitor cells in vitro in a dose-dependent manner. [Nat Commun] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Researchers elucidated their antigen repertoire recognized by spontaneous T-cell responses using an unbiased proteomic approach. Protein fractionations of tissue lysates from IDH mut gliomas were performed. Fractions were tested by IFN-mE; ELISpot assay for recognition through patient’s T-cells. [Clin Cancer Res] Abstract TSLP Signaling in CD4+ T Cells Programs a Pathogenic T Helper 2 Cell State In human CD4+ T cells, thymic stromal lymphopoietin (TSLP) and interleukin-5 (IL-4) promoted the generation of T helper 2 cells that produced greater amounts of IL-5 and IL-13. [Sci Signal] Abstract A Critical Epitope in CD147 Facilitates Memory CD4+ T-Cell Hyper-Activation in Rheumatoid Arthritis Scientists demonstrated that CD147 was predominantly upregulated in memory T (Tm) cells derived from rheumatoid arthritis patients. The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis. [Cell Mol Immunol] Full Article TREM-1 Multimerization Is Essential for Its Activation on Monocytes and Neutrophils Triggering receptor expressed on myeloid cells-1 (TREM-1) activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface, in contrast to primary human neutrophils, where LPS induced a rapid cell membrane reorganization of TREM-1, which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes. [Cell Mol Immunol] Abstract Investigators demonstrated that human dendritic cells (DCs) synergistically activated by a combination of factor VIII (FVIII) concentrate plus the bacterial danger signal lipopolysaccharide (LPS) induced a significantly stronger activation of autologous CD4+ T cells than DCs pretreated with FVIII or LPS alone. [Thromb Haemost] Abstract Scientists investigated the circulating T-cell compartment of 34 patients with metastatic melanoma and 42 controls, which were classified as either young or old. Absolute numbers of CD4+ T cells were decreased in young and old melanoma patients when compared to the age-matched control groups. [Cancer Immunol Immunother] Full Article Scientists explored the biological function and clinical significance of tripartite motif containing 28 (TRIM28) in B-cell non-Hodgkin lymphoma (B-NHL). They displayed that high expression of TRIM28 was positively associated with the poorer survival of B-NHL patients as an independent prognostic factor. [Leuk Lymphoma] Abstract The authors showed that strongly proinflammatory and anti-tumor invariant natural killer T (iNKT) cell responses were achieved in mice by a variant of α-galactosylceramide that combines a sphinganine base with a hydrocinnamoyl ester on C6′ of the sugar. Importantly, the activities observed with this variant were largely preserved for human iNKT cell responses. [Cell Chem Biol] Abstract | Graphical Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
| |
REVIEWSChemokine and Chemotactic Signals in Dendritic Cell Migration The correct localization of dendritic cells is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, danger-associated molecular patterns, complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. [Cell Mol Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
| |
INDUSTRY NEWSSymbiotix Biotherapies Announces License Agreement with Harvard University Symbiotix Biotherapies, Inc. announced that it has entered into a license agreement with Harvard University. Under the agreement, Symbiotix gains access to a portfolio of intellectual property developed in the laboratory of Dennis Kasper, M.D., William Ellery Channing Professor of Medicine and Professor of Microbiology and Immunobiology at Harvard Medical School. [Symbiotix Biotherapies, Inc.] Press Release Helix BioPharma Corp. announced the completion of the collaboration agreement with ProMab Biotechnologies, Inc. [Helix BioPharma Corp. (GlobeNewswire, Inc.)] Press Release | |
| |
POLICY NEWSASCO Names CAR T-Cell Immunotherapy Its Clinical Advance of the Year The Society urges sustained federal research investment to accelerate the next generation of cancer treatments. [HSP News Service, L.L.C.] Editorial Cambridge Analytica Controversy Must Spur Researchers to Update Data Ethics Revelations keep emerging in the Cambridge Analytica personal-data scandal, which has captured global public attention. But when the dust settles, researchers harvesting data online will face greater scrutiny. And so they should. [Nature News] Editorial Duke’s Mishandling of Misconduct Prompts New U.S. Government Grant Oversight The U.S. National Institutes of Health imposed unusual new requirements on researchers based at Duke University in Durham, North Carolina, who receive federal funds. The changes are a response to concerns over how the institution handled recent cases involving research misconduct and grant management. [ScienceInsider] Editorial Massive Cyberhack by Iran Allegedly Stole Research from 320 Universities, Governments, and Companies Nine Iranians working on behalf of the Islamic Revolutionary Guard Corps hacked the computers of 7998 professors at 320 universities around the world over the past five years, an indictment filed by a federal grand jury alleges. [ScienceInsider] Editorial
| |
EVENTSNEW 3D Cell Culture 2018 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Position – Onco-ImmunoMetabolism (San Raffaele Scientific Institute) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Positions – Immunology, Genetics and Precision Medicine (Ludwig Boltzmann Institute) Assistant/Associate Professor – Immunology (Saint Louis University) Postdoctoral Position – Immune Oncology (H. Lee Moffitt Cancer & Research Institute) Scientist – Immune Tolerance (Moderna Therapeutics) Postdoctoral Fellow – Immunology and iPSCs (Stanford University) Postdoctoral Research Associate – Immunity and Inflammation (University of Illinois) Principal Scientist – Immunosciences Drug Discovery (Bristol-Myers Squibb) Postdoctoral Fellow – T-Cell Therapy (Memorial Sloan Kettering Cancer Center) PhD Studentship – Treg Cell Research (Universitätsklinikum Carl-Gustav-Carus Dresden) Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai) Senior Director – Immuno-Oncology Research (Alector LLC) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Human Immunology News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|