Human Immunology News Volume 6.13 | Apr 3 2018

TOP STORY

Breast and Pancreatic Cancer Interrupt IRF8-Dependent Dendritic Cell Development to Overcome Immune Surveillance

Investigators postulated that myelopoiesis might impact conventional dendritic cells (cDC) development. The cDC subset, cDC1, which includes human CD141⁺ DCs and mouse CD103⁺ DCs, supports anti-tumor immunity by stimulating CD8⁺ T-cell responses. To understand how cDC1 development changes during tumor progression, they investigated cDC bone marrow progenitors. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Trophoblast-Derived CXCL16 Induces M2 Macrophage Polarization that In Turn Inactivates NK Cells at the Maternal-Fetal Interface

CXCL16 derived from first-trimester trophoblast cells induced the polarization of human M2 macrophages (MΦs). The M2 MΦ polarized by CXCL16 exhibited decreased interleukin-15 production, which facilitated the inactivation of natural killer (NK) cells. [Cell Mol Immunol] Full Article

Type I Interferons Promote the Survival and Proinflammatory Properties of Transitional B Cells in Systemic Lupus Erythematosus Patients

The authors performed an extensive examination of B-cell subsets and their proinflammatory properties in a Chinese cohort of new-onset systemic lupus erythematosus (SLE) patients. They observed that SLE patients exhibited an increased frequency of transitional B cells compared with healthy donors and rheumatoid arthritis patients. [Cell Mol Immunol] Abstract

The Impact of Circulating Preeclampsia-Associated Extracellular Vesicles on the Migratory Activity and Phenotype of THP-1 Monocytic Cells

Scientists proved extracellular vesicle (EV) binding and uptake by THP-1 cells. Cellular origin and protein cargo of circulating preeclampsia-associated-EVs were characterized by flow cytometry and mass spectrometry. [Sci Rep] Full Article

Cementoin-SLPI Fusion Protein Binds to Human Monocytes and Epithelial Cells and Shows Higher Biological Activity than SLPI

Researchers observed that fusion protein (FP) retained its antiprotease activity and that at equimolar amount of proteins, FP was more efficient than secretory leukocyte proteinase inhibitor (SLPI) in the inhibition. Both, FP and SLPI inhibited IL-2-induced lymphocyte proliferation, however, lower amounts of FP were required to achieve this inhibition. [Sci Rep] Full Article

Excessive Activated T-Cell Proliferation after Anti-CD19 CAR T-Cell Therapy

Excessive activated T-cell proliferation was observed in vivo in one patient after an anti-CD19-chimeric antigen receptor (CAR) T-cell infusion. [Gene Ther] Abstract

Decreased PD-1 Expression on Circulating CD4⁺T Cell and PD-L1 Expression on Myeloid Dendritic Cells Correlate with Clinical Manifestations in Systemic Juvenile Idiopathic Arthritis

Researchers aimed to reveal the circulating cell profile and the relative programmed cell death-1 (PD-1)/programmed cell death-1 ligand (PD-L1) expression of juvenile idiopathic arthritis subsets, elucidating their underlying immunomodulatory mechanisms. [Joint Bone Spine] Abstract

DEC1/STRA13 Is a Key Negative Regulator of Activation-Induced Proliferation of Human B Cells Highly Expressed in Anergic Cells

The authors showed that, unlike in mice, DEC1/STRA13 expression is induced in human naïve and memory resting B cells by activation through the B-cell receptor or Toll-like receptor 9. [Immunol Lett] Abstract

Amniotic Membrane Extract Differentially Regulates Human Peripheral Blood T Cell Subsets, Monocyte Subpopulations and Myeloid Dendritic Cells

Researchers investigated the effect of human amniotic membrane extract on the pattern of cytokine production by T cells, monocytes and myeloid dendritic cells. [Cell Tissue Res] Abstract

Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News.

Development of Mucosal-Associated Invariant T (MAIT) Cells

Scientists discuss how MAIT cells transition through a three-stage development pathway in both mouse and human thymus, and continue to mature and expand after they leave the thymus. Moreover, they explore and speculate on how specific factors regulate different stages of this process. [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

bluebird bio and Celgene Corporation Enter into Agreement to Co-Develop and Co-Promote Anti-BCMA CAR T Cell Therapy bb2121 in the United States

bluebird bio, Inc. and Celgene Corporation announced that the companies have entered into an agreement to co-develop and co-promote bb2121, an investigational anti-B-cell maturation antigen (BCMA) CAR T cell therapy for the potential treatment of patients with relapsed/refractory multiple myeloma in the United States. [bluebird bio, Inc.] Press Release

Pfizer and Allogene Therapeutics Enter into Asset Contribution Agreement for Pfizer’s Allogeneic CAR T Immuno-Oncology Portfolio

Pfizer Inc. and Allogene Therapeutics, Inc. announced that the two companies have entered into an asset contribution agreement for Pfizer’s portfolio of assets related to allogeneic chimeric antigen receptor T cell (CAR T) therapy, an investigational immune cell therapy approach to treating cancer. [Pfizer Inc.] Press Release

Cancer Researchers Push to Relax Rules for Clinical Trials

US government examines whether criteria for participating in drug studies unnecessarily exclude some people. [Nature News] Editorial

EU Copyright Reforms Draw Fire from Scientists

An influential committee of the European Parliament is due to vote on changes to copyright regulations in the European Union (EU), but the latest drafts of the rules have triggered a wave of criticism from open-science advocates. They say that the proposals will stifle research and scholarly communication. [Nature News] Editorial

French Universities Cancel Subscriptions to Springer Journals

French research organizations and universities have canceled their subscriptions to Springer journals, due to an impasse in fee negotiations between the publisher and Couperin.org, a national consortium representing more than 250 academic institutions in France. [The Scientist] Editorial

In Emotional Speech, CDC’s New Leader Vows to Uphold Science

Robert Redfield Jr., the new director of the Centers for Disease Control and Prevention (CDC), gave a deeply personal agency-wide address in which he repeatedly underscored the importance of science and data and said the CDC’s most critical public health mission is to protect Americans “from that which we don’t expect”. [The Washington Post] Editorial

Cancer Researcher at the Ohio State University Resigns following Multiple Misconduct Findings

A cancer researcher has resigned from The Ohio State University in Columbus after the institution determined he had committed misconduct in eight papers. His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials. [ScienceInsider] Editorial

NEW 23^rd Congress of European Hematology Association (EHA)
June 14-17, 2018
Stockholm, Sweden

Visit our events page to see a complete list of events in the community.

NEW Research Scientist – Biomarker Development (Kymab)

Research Technologist – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Onco-ImmunoMetabolism (San Raffaele Scientific Institute)

Assistant/Associate Professor – Immunology (Saint Louis University)

Postdoctoral Fellow – Allergic Disease Inflammation Research (La Jolla Institute for Allergy & Immunology)

Postdoctoral Position – Immune Oncology (H. Lee Moffitt Cancer & Research Institute)

Scientist – Immune Tolerance (Moderna Therapeutics)

Postdoctoral Fellow – Immunology and iPSCs (Stanford University)

Postdoctoral Research Associate – Immunity and Inflammation (University of Illinois)

Principal Scientist – Immunosciences Drug Discovery (Bristol-Myers Squibb)

Postdoctoral Fellow – T-Cell Therapy (Memorial Sloan Kettering Cancer Center)

Senior Director – Immuno-Oncology Research (Alector LLC)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Human Immunology News? Click here to submit!

Comments or suggestions? Submit your feedback here.