Human Immunology News 6.21 May 29, 2018 | |
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TOP STORYSpatial Distribution and Function of T Follicular Regulatory Cells in Human Lymph Nodes Using highly multiplexed quantitative imaging and functional assays, the authors examined the spatial distribution, suppressive function, and preferred interacting partners of T follicular regulatory cells in human mesenteric lymph nodes. [J Exp Med] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Adaptive NK Cells Resist Regulatory T Cell Suppression Driven by IL-37 Researchers showed that canonical natural killer (NK) cells are highly susceptible to regulatory T cell-mediated suppression, in contrast to highly resistant CD57+ FcεRγ-NKG2C+ adaptive NK cells that expand in cytomegalovirus-exposed individuals. [Cancer Immunol Res] Abstract Aberrant Expansion and Function of T Follicular Helper Cell Subsets in IgG4-Related Disease Mononuclear cells from peripheral blood and involved tissues of IgG4-RD patients were collected. Tfh cell subsets, mRNA levels of Bcl-6, Blimp-1 and IL-21 were tested. Immunohistochemistry and immunofluorescence techniques were used to assess the location of IL-21, Bcl-6, and Tfh cells in the involved tissues. [Arthritis Rheumatol] Abstract | Full Article Loss of 5-Hydroxymethylcytosine Is an Epigenetic Biomarker in Cutaneous T Cell Lymphoma The authors report that the loss of DNA hydroxymethylation at the 5 position of cytosine (5-hmC) is an epigenetic hallmark of cutaneous T cell lymphoma, with diagnostic and prognostic implications. Immunohistochemistry staining on 90 mycosis fungoides (MF) cases demonstrated a significant decrease of 5-hmC staining in CD4+ T cells in patch and tumor stages, especially in MF-LCT, compared to benign inflammatory dermatoses. [J Invest Dermatol] Abstract Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis Investigators found that naive CD4+ T cells, but not memory T cells, expressed high levels of chemokine CXCL8. [J Immunol] Abstract Scientists identified a protumorigenic subset of macrophages that constitutively expressed programmed cell death 1 (PD1) and accumulated in advanced-stage gastric cancer. [Oncogenesis] Full Article Mosquito Saliva Alone Has Profound Effects on the Human Immune System Investigators describe the numerous effects that mosquito bites have on human immune cells in mice engrafted with human hematopoietic stem cells. They used flow cytometry and multiplex cytokine bead array assays, with detailed statistical analyses, to detect small but significant variations in immune cell functions after four mosquitoes fed on humanized mice footpads. [PLoS Negl Trop Dis] Full Article | Press Release Distinctive CD8+ T Cell and MHC Class I Signatures in Polycythemia Vera Patients Investigators performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2m-associated and β2m-free MHC class I heavy chains, also known as closed and open conformers, respectively, in polycythemia vera patients and age-matched controls. [Ann Hematol] Abstract PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function Researchers found that the n-3 docosapentaenoic acid-derived protectin (PDn-3 DPA) biosynthetic pathway regulated the differentiation of human monocytes, altering macrophage phenotype, efferocytosis, and bacterial phagocytosis. [Cell Chem Biol] Abstract | Graphical Abstract Regulatory T Cells Induce Activation Rather Than Suppression of Human Basophils Researchers report that human basophils are refractory to regulatory T cell (Treg)-mediated suppression and found that Tregs stimulate resting basophils to induce the expression of activation markers including CD69, CD203c, and CD13 and the release of basophil cytokines including IL-13, IL-8, and IL-4. [Sci Immunol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSAdvances on Chimeric Antigen Receptor-Modified T-Cell Therapy for Oncotherapy The authors describe the history and evolution of chimeric antigen receptor T (CAR-T), generalizes the structure and preparation of CAR-T, and summarizes the latest advances on CAR-T cell therapy in different tumor types. [Mol Cancer] Full Article Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSMesoblast Limited announced that it has entered into a partnership with Cartherics Pty Ltd to develop allogeneic ‘off-the-shelf’ CAR-T cells armed with multiple targeting receptors for use in solid cancers. [Mesoblast Limited] Download Press Release INmune Bio Initiates Phase I Clinical Trial of INB03 INmune Bio, Inc. announced that it has initiated a Phase I clinical trial of its drug candidate INB03™ in patients with advanced solid tumors. [INmune Bio, Inc.] Press Release U-M Rogel Cancer Center First in Michigan to Offer All FDA Approved CAR T-Cell Therapies With the recently announced FDA approval of Kymriah to treat adults with lymphoma, the University of Michigan (U-M) Rogel Cancer Center is the first center in Michigan to offer all currently available CAR T-cell therapies. [U-M Rogel Cancer Center] Press Release | |
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POLICY NEWSItaly’s New Prime Minister Defended Discredited Stem Cell Therapy The electoral victory of two populist parties in March had Italian scientists worried that a new era of antiscientific policies might be around the corner—and appointment of Giuseppe Conte as the country’s new prime minister is making some even more nervous. [ScienceInsider] Editorial Scientist Who Received Millions from NIH Leaves Alabama Posts A professor who received about $5 million in grants from the National Institutes of Health left his posts at the University of Alabama, Birmingham, and Birmingham VA Medical Center last year after an investigation found evidence of image manipulation in 20 of his papers, Retraction Watch has learned. [The Scientist] Editorial
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