Human Immunology News 6.25 June 26, 2018 | |
| |
TOP STORYModulation of EZH2 Expression in T Cells Improves Efficacy of Anti-CTLA-4 Therapy Pharmacological inhibition of EZH2 in human T cells using CPI-1205 elicited phenotypic and functional alterations of the regulatory T cells and enhanced cytotoxic activity of effector T cells. [J Clin Invest] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Immune Cell Contexture in the Bone Marrow Tumor Microenvironment Impacts Therapy Response in CML The authors characterized the immune landscape of the chronic myeloid leukemia (CML) bone marrow and predicted the current treatment goal of tyrosine kinase inhibitor therapy, molecular remission 4.0. CML patients’ CD4+ and CD8+ T-cells expressed higher levels of putative exhaustion markers PD1, TIM3, and CTLA4 when compared to control. [Leukemia] Full Article To elucidate the transcriptional landscape in diverse immune cell types of peripheral blood cells (PBC) in stage IV melanoma, scientists used whole transcriptome RNA sequencing to profile lncRNAs in CD4+, CD8+, and CD14+ PBC from 132 patient samples. [Cancer Res] Abstract Scientists showed that GPR183, a chemotactic receptor expressed on murine and human group 3 innate lymphoid cells (ILC3s), regulates ILC3 migration toward its ligand 7α,25-dihydroxycholesterol in vitro, and GPR183 deficiency in vivo leads to a disorganized distribution of ILC3s in mesenteric lymph nodes and decreased ILC3 accumulation in the intestine. [Cell Rep] Full Article | Graphical Abstract Investigators aimed to establish whether CD11b-ligated moDC modulate Th17-cell effector reponses to assess their potential for future use in moDC-based suppressive immunotherapy. [J Autoimmun] Abstract CXCL4/Platelet Factor 4 Is an Agonist of CCR1 and Drives Human Monocyte Migration Investigators demonstrated that CXCL4 drives chemotaxis of the monocytic cell line THP-1. Migration and intracellular calcium responses induced by CXCL4 were pertussis toxin-sensitive, implicating a GPCR in signal transduction. [Sci Rep] Full Article Comparing patients developing post-operative atrial fibrillation (POAF) to individuals free of POAF the fraction of CD4+CD28null T Lymphocytes was significantly higher in individuals developing POAF. [Sci Rep] Full Article To assess the percentage of CD4+CD28null T lymphocytes, natural killer cells, and IFN-gamma levels, the authors compared 40 children and adolescents with sickle cell disease with 40 healthy controls and evaluated their relation to disease severity and response to therapy. [Immunol Res] Abstract The Exhausted CD4+CXCR5+ T Cells Involve the Pathogenesis of Human Tuberculosis Disease The frequency and function of CD4+CXCR5+ T cells were evaluated in active tuberculosis patients and healthy control individuals. The function of CD4+CXCR5+ T cells was determined after blockade of inhibitory receptors. [Int J Infect Dis] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
| |
REVIEWSReassessing B Cell Contributions in Multiple Sclerosis Researchers review recent advances in the field of multiple sclerosis, which has traditionally been viewed as primarily a T cell-mediated disease, and they consider antibody-dependent and, particularly, emerging antibody-independent functions of B cells that may be relevant in both the peripheral and central nervous system disease compartments. [Nat Immunol] Full Article Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
| |
INDUSTRY NEWSAbbVie and Calibr Announce Collaboration for Next Generation T-Cell Therapies AbbVie and Calibr announced a collaboration to develop T-cell therapies aimed primarily at cancer, including solid tumors. [AbbVie Inc.] Press Release Caladrius Biosciences, Inc. announced that the FDA has granted regenerative medicine advanced therapy designation to the company’s late-stage CD34+ cell therapy program for the treatment of refractory angina. [Caladrius Biosciences, Inc.] Press Release Atara Biotherapeutics, Inc. announced the opening of its Atara T-Cell Operations and Manufacturing facility in Thousand Oaks, California. [Atara Biotherapeutics, Inc.] Press Release Mustang Bio Announces Opening of CAR T Cell Therapy Manufacturing Facility in Worcester, Mass. Mustang Bio, Inc. announced that it has opened a CAR T cell therapy manufacturing facility at UMass Medicine Science Park in Worcester, Mass. [Mustang Bio, Inc.] Press Release | |
| |
POLICY NEWSThe European country’s autocratic government has made a disturbing grab at the nation’s scientific institutions. [Nature News] Editorial Senate Panel Proposes $2 Billion, 5.4% Increase for NIH A U.S. Senate appropriations subcommittee approved a spending bill that calls for giving the National Institutes of Health (NIH) a $2 billion, 5.4% increase to $39.1 billion in the 2019 fiscal year that begins 1 October. [ScienceInsider] Editorial New Group Aims to Bolster Science in Policymaking Symbolically, it’s pushing back against the Trump administration’s efforts to cut research funding. Practically, it’s providing grant money to academic researchers in a wide variety of scientific fields, including biomedical, life, engineering, physical, law and public policy. [Scientific American] Editorial White House Proposes a Narrowing of FDA’s Mission — And a New Name The Trump administration has proposed a fundamental change to the mission of the FDA, one that would transfer most of the responsibility for regulating food safety to the Department of Agriculture and rename the FDA the “Federal Drug Administration”. [STAT News] Editorial US-Chinese Trade War Puts Scientists in the Cross Hairs Scientific research in the United States could become collateral damage in the country’s escalating trade dispute with China. Both countries went head-to-head in mid-June over tariffs on a long list of goods that includes lab equipment and reagents. That is likely to increase the cost of scientific research, and the impact could be felt more keenly in US labs. [Nature News] Editorial African Scientists Launch Their Own Preprint A group of open science advocates have launched the first preprint aimed exclusively at African scientists. AfricArxiv seeks to improve the visibility of African science by helping academics share their work quickly, say co-founders Justin Ahinon, and Jo Havemann. [Nature News] Editorial
| |
EVENTSNEW Infection and Chronic Disease Meeting NEW 4th European Platelet Network (EUPLAN) Conference 2018 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESResearch Technologist – Cell Separation (STEMCELL Technologies Inc.) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Postdoctoral Fellow – Immunoengineering for Muscle Regeneration (Duke University) PhD Student Positions – Immunology (Multiple Locations) Postdoctoral Fellow – Immunology (Boston University School of Medicine) Postdoctoral Fellow – Innate Immune Signaling (Houston Methodist Research Institute) Scientist/Senior Scientist – Lentivirus Production (Obsidian Therapeutics) Scientist/Senior Scientist – Bioinformatics and Data Sciences (Obsidian Therapeutics) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Human Immunology News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|