Human Immunology News Volume 6.40 | Oct 9 2018

TOP STORY

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

Scientists report an unexpected finding that macrophages after antibody-dependent cellular phagocytosis (ADCP) inhibited NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

Acute activation of myeloid cells induced itaconate synthesis, which subsequently mediated innate immune tolerance in human monocytes. [Cell Metab] Abstract | Graphical Abstract

Siglec-7 Engagement by GBS β-Protein Suppresses Pyroptotic Cell Death of Natural Killer Cells

Researchers observed that the human neonatal pathogen group B Streptococcus (GBS) could directly engage human natural killer cells. [Proc Natl Acad Sci USA] Abstract

IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages

In a genome-wide small interfering RNA screen of the lipopolysaccharide (LPS)-induced tumor necrosis factor α response in macrophages, investigators identified the interferon-stimulated protein IFIT1 as a negative regulator of the inflammatory gene program. [Cell Rep] Full Article | Graphical Abstract

Increased Expression of Interleukin-9 in Patients with Allergic Contact Dermatitis Caused by p-Phenylenediamine

Scientists observed increased expression of T cell markers and Th2/Th9-associated cytokines in both skin and stimulated peripheral blood mononuclear cells of p-phenylenediamine-allergic patients. [Contact Dermatitis] Abstract

Comparative Transcriptomic Profile of Tolerogenic Dendritic Cells Differentiated with Vitamin D3, Dexamethasone and Rapamycin

The authors compared the transcriptomic profile of tolerogenic dendritic cell induced with either vitamin D3, dexamethasone or rapamycin through a microarray analysis in five healthy donors. [Sci Rep] Full Article

Expression of IL-3 Receptors and Impact of IL-3 on Human T and B Cells

Researchers showed that the IL-3 receptor CD123 was substantially upregulated on proliferating CD4⁺ and CD8⁺ T as well as B cells. [Cell Immunol] Abstract

Prediction of Intravesical Recurrence of Non-Muscle-Invasive Bladder Cancer by Evaluation of Intratumoral Foxp3⁺ T Cells in the Primary Transurethral Resection of Bladder Tumor Specimens

The authors revealed the association between prognosis of non-muscle-invasive bladder cancer and infiltration of Foxp3⁺ T cells that suppress anti-tumor immunity in 115 primary non-muscle-invasive bladder cancer patients retrospectively identified and followed for at least three months after primary transurethral resection. [PLoS One] Full Article

Enhanced Detection of Neoantigen-Reactive T Cells Targeting Unique and Shared Oncogenes for Personalized Cancer Immunotherapy

Scientists investigated whether the detection of neoantigen-reactive tumor-infiltrating lymphocytes could be enhanced by enriching T cells that express PD-1 and/or T cell activation markers followed by microwell culturing to avoid overgrowth of nonreactive T cells. [JCI Insight] Full Article

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Noncoding RNA in NK Cells

The authors summarize and discuss the latest studies on the functions and regulatory mechanisms of long noncoding RNA and microRNA in NK cells from the viewpoint of epigenetic mechanisms to help us clearly understand noncoding RNAs in NK cells. [J Leukoc Biol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

eTheRNA Opens State-of-the-Art Manufacturing Facility in Belgium to Support the Development of Its TriMix-Based mRNA Cancer Immunotherapies

eTheRNA Immunotherapies announced the opening of a state-of-the-art mRNA manufacturing facility enabling the production of mRNA immunotherapies. [eTheRNA Immunotherapies NV] Press Release

Biohaven Acquires Option to License Biologic Investigational Agent for Inflammatory and Autoimmune Diseases from The University of Connecticut

Biohaven Pharmaceutical Holding Company Ltd. announced that it signed an exclusive, worldwide option and license agreement with the University of Connecticut for the development and commercialization rights to UC1MT, a therapeutic antibody targeting extracellular metallothionein. [Biohaven Pharmaceutical Holding Company Ltd.] Press Release

Columbia University Postdocs Vote to Unionize

Postdocs at Columbia University voted to unionize, with representation from the United Auto Workers, according to The Associated Press. The organization represents the first postdoc union at a private university in the United States. [The Scientist] Editorial

Was Cancer Scientist Fired for Challenging Lab Chief over Authorship?

Rutgers University terminated a veteran cancer scientist in retaliation, the researcher says, for challenging a powerful principal investigator on the authorship of a paper apparently accepted for publication in Nature. The researcher is now deciding whether to appeal her dismissal in arbitration through her union or to sue Rutgers. [ScienceInsider] Editorial

Major Publishers Sue ResearchGate over Copyright Infringement

Two journal publishers have launched legal proceedings in the United States against academic-networking site ResearchGate for copyright infringement. [Nature News] Editorial

NEW 47^th Annual Scientific Meeting of the Australasian Society for Immunology
December 2-6, 2018
Perth, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Statistical Geneticist/Computational Biologist (Wellcome Sanger Institute)

Research Technologist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Autophagy and Aging (University of Oxford)

Research Assistant II – Immunology (Baylor College of Medicine)

Faculty Position – Immunology (Benaroya Research Institute)

Faculty Position – Systems Immunology (Benaroya Research Institute)

Project Leader – Immuno-Oncology (CELLECTIS Inc.)

Postdoctoral Fellowship – Immunology (University of Nantes)

Postdoctoral Fellow – Foxp3+ T-Regulatory in Autoimmunity and Transplantation (Children’s Hospital of Philadelphia)

Postdoctoral Associates – Cancer Immunology and/or Bioinformatics (Emory University)

Institute Group Leader – Lymphocyte Biology (MD Anderson Cancer Center)

Postdoctoral Fellow – Cancer Therapeutics and Immunotherapy (Emory University)

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