Human Immunology News 7.09 March 12, 2019 | |
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TOP STORYA Clinically Meaningful Metric of Immune Age Derived from High-Dimensional Longitudinal Monitoring Scientists used multiple ‘omics’ technologies to capture population- and individual-level changes in the human immune system of 135 healthy adult individuals of different ages sampled longitudinally over a nine-year period. [Nat Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Deciphering CD4+ T Cell Specificity Using Novel MHC-TCR Chimeric Receptors Researchers describe a platform for the discovery of major histocompatibility complex (MHC) class II epitopes based on the screening of engineered reporter cells expressing novel peptide and MHC T cell antigen receptor (TCR) hybrid molecules carrying cDNA-derived peptides. [Nat Immunol] Abstract A Year-Long Immune Profile of the Systemic Response in Acute Stroke Survivors Investigators used a single-cell mass cytometry approach to comprehensively and functionally characterize the systemic immune response to stroke in longitudinal blood samples from 24 patients over the course of one year and correlated the immune response with changes in cognitive functioning between 90 and 365 days post-stroke. [Brain] Full Article Researchers surveyed the functional consequences of CBFβ-MYH11 in primary inv(16) patient blasts, upon expression during hematopoietic differentiation in vitro and upon knockdown in cell lines by multi-omics profiling. [Blood Cancer J] Full Article Functional Proteomic Atlas of HIV Infection in Primary Human CD4+ T Cells Scientists obtained pure populations of HIV-infected primary human CD4+ T cells for detailed proteomic analysis, and quantitated approximately 9000 proteins across multiple donors on a dynamic background of T cell activation. [eLife] Full Article Coexpression of CD163 and CD141 Identifies Human Circulating IL-10-Producing Dendritic Cells (DC-10) By in vitro gene expression profiling of differentiated human dendritic cells, researchers identified CD141 and CD163 as surface markers for DC-10. The coexpression of CD141 and CD163 in combination with CD14 and CD16 enabled the ex vivo isolation of DC-10 from peripheral blood. [Cell Mol Immunol] Full Article T-cell cytotoxicity towards adipose-derived mesenchymal stem cells (ADSCs) grown in xeno-free medium (XF-ADSCs) was lower than that towards ADSCs exposed to xenogeneic serum or proinflammatory cytokines, but XF-ADSCs still induced cytotoxicity. [Exp Mol Med] Full Article Freeze-thawed/pre-cultured peripheral blood mononuclear cells and whole blood samples from donors were stimulated with reagents spanning different monoclonal antibody functional classes to evaluate the association of Fc gamma receptor (FcγR) genotypes with T-cell proliferation and cytokine release. [Front Immunol] Full Article HIV Infection and Latency Induce a Unique Metabolic Signature in Human Macrophages Investigators showed that HIV infection of macrophages results in survival of a small population of infected cells that are metabolically altered and characterized by mitochondrial fusion, lipid accumulation, and reduced mitochondrial ATP production. [Sci Rep] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSThe authors present an overview of neutrophil heterogeneity and discuss possible mechanisms of diversification, including genomic regulation. [Nat Rev Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSSTEMCELL Technologies Wins Deloitte Best Managed Companies Award STEMCELL Technologies announced that the company has been selected as a winner of Canada’s Best Managed Companies program for 2019. Canada’s Best Managed Companies is the country’s leading business awards program, recognizing excellence in the management abilities and practices of Canadian owned and managed companies with revenues over $15 million. [STEMCELL Technologies Inc.] Press Release Biocartis Group NV announced the signing of a collaboration agreement with Bristol-Myers Squibb Company aimed at the potential registration as a companion diagnostic and use of the Idylla™ MSI test in connection with immuno-oncology therapies. [Biocartis Group NV] Press Release NKMax America announced that the FDA has accepted the Investigational New Drug (IND) application for SNK01, an autologous NK cell adoptive immunotherapy candidate for the treatment of patients with pathologically confirmed cancer refractory to conventional therapy. [NKMax America, Inc.] Press Release | |
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POLICY NEWSNed Sharpless, Director of the National Cancer Institute, to Be Named Acting FDA Commissioner The Trump administration announced it would name Ned Sharpless, the director of the National Cancer Institute, the acting commissioner of the FDA next month. The announcement came just a week after the current commissioner, Scott Gottlieb, announced he plans to resign in early April. [STAT News] Editorial Trump Once Again Requests Deep Cuts in US Science Spending For the third year in a row, President Donald Trump’s administration has unveiled a budget request to Congress that calls for deep spending cuts at many federal science agencies, including a 15% cut for the National Institutes of Health and a 12% cut for the National Science Foundation, while providing hefty increases for the military. [ScienceInsider] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2019 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Immunology (Fox Chase Cancer Center) Research Technologist – Immunology (STEMCELL Technologies Inc.) Research Fellow – Protective and Aberrant Immunity (Monash University) Computational Biologist – Aging (NIH National Institute on Aging) Postdoctoral Position – Tumor Immunology (University of Maryland) Postdoctoral Positions – Human Immunology (University of California, San Francisco) Staff Scientist – Immunology (Cellzome) Postdoctoral Fellow – Tumor Immune Evasion (Luxembourg Institute of Health) Postdoctoral Positions – Immunity (UT Southwestern Medical Center) Investigator Positions – Cancer Immunology (University of Alabama Birmingham) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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