Human Immunology News 7.23 June 18, 2019 | |
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TOP STORYA Cellular Census of Human Lungs Identifies Novel Cell States in Health and in Asthma Researchers used single-cell transcriptomics to chart the cellular landscape of upper and lower airways and lung parenchyma in healthy lungs, and lower airways in asthmatic lungs. They report location-dependent airway epithelial cell states and a novel subset of tissue-resident memory T cells. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Fc Glycan-Mediated Regulation of Placental Antibody Transfer Scientists used systems serology to define Fc features associated with antibody transfer. The Fc-profile of neonatal and maternal antibodies differed, skewed toward natural killer cell-activating antibodies. [Cell] Abstract | Press Release | Graphical Abstract The Immune Cell Landscape in Kidneys of Patients with Lupus Nephritis To develop mechanistic hypotheses of disease, the authors analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. They revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses. [Nat Immunol] Abstract Investigators found that innate lymphoid cell (ILC)3s and ILC1s in human tonsils represented the ends of a spectrum that included additional discrete subsets. [Nat Immunol] Abstract Functional Paralysis of Human Natural Killer Cells by Alphaherpesviruses Scientists demonstrated that varicella zoster virus potently impaired the ability of natural killer cells to respond to target cell stimulation in vitro, leading to a loss of both cytotoxic and cytokine responses. [PLoS Pathog] Full Article Researchers report the development of immunotherapy using human lymphocytes transduced with a codon-optimized melanoma-associated antigen-A4 and HLA-A*2402-restricted T-cell receptor (TCR), which specifically downregulated endogenous TCR by small interfering RNA. [Cell Death Dis] Full Article The authors compared the monocyte-derived macrophage (MDM) profile obtained from coronary artery disease (CAD) patients and healthy subjects, and they evaluated the association between CAD MDM profile and in vivo coronary plaque characteristics assessed by optical coherence tomography. [Sci Rep] Full Article To identify the characteristics of IgG B-cell receptor repertoires in immune thrombocytopenia, investigators took advantage of adaptor-ligation PCR and high-throughput DNA sequencing methods for analyzing the clone-based repertoires of IgG-expressing peripheral blood B cells. [Sci Rep] Full Article Non-alcoholic steatohepatitis (NASH) was associated with alterations in blood immune cell populations, including conventional dendritic cells type 1 and 2, and cytotoxic CD8 T cells. Lobular inflammation and ballooning were associated with the accumulation of CD8 T cells in the liver. [Nat Metab] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSγδ T Cells: Pleiotropic Immune Effectors with Therapeutic Potential in Cancer The authors outline both seminal work and recent advances in the understanding of how γδ T cells participate in tumor immunity and how their functions are regulated in experimental models of cancer. [Nat Rev Cancer] Abstract Interferon-λ Orchestrates Innate and Adaptive Mucosal Immune Responses Scientists highlight recent work showing that interferon (IFN)-λ inhibits virus dissemination within the body and limits the transmission of respiratory and gastrointestinal viruses to naive hosts. They also discuss findings indicating that IFN-λ can act on neutrophils to prevent invasive pulmonary aspergillosis. [Nat Rev Immunol] Abstract Metabolic Adaptations of Tissue-Resident Immune Cells Researchers discuss the available data on the metabolic adaptation of immune cells to life in different tissue sites, within the broader framework of how functional adaptation versus maladaptation in the niche can affect tissue homeostasis. [Nat Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSFirst Patient Dosing in Phase I Clinical Trial of Anti-CD20 CAR-T for Lymphoma in China Cellular Biomedicine Group Inc. announced that it has initiated its Phase I Clinical Trial of anti-CD20 chimeric antigen receptor T-cell targeting anti-CD19 treated, relapsed diffuse large B-cell lymphoma (DLBCL) and small B-cell lymphoma patients in China, and dosed the first CD19 CAR-T relapsed DLBCL patient. [Cellular Biomedicine Group Inc.] Press Release Ziopharm Oncology Announces FDA Clearance of IND for Sleeping Beauty TCR-T Cell Therapy Trial at NCI Ziopharm Oncology, Inc. announced that the investigational new drug (IND) application submitted by the National Cancer Institute (NCI) has received clearance from the FDA for a clinical trial in solid tumors to evaluate T-cell receptor (TCR) T-cell therapy utilizing Ziopharm’s Sleeping Beauty platform. [Ziopharm Oncology, Inc.] Press Release CASI Pharmaceuticals Acquires Worldwide Rights to Commercialize Anti-CD19 T-Cell Therapy CASI Pharmaceuticals, Inc. announced the signing of a license agreement for exclusive worldwide license and commercialization rights to an autologous anti-CD19 T-cell therapy product from Juventas Cell Therapy Ltd. [CASI Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSAfrica’s Science Academy Leads Push for Ethical Data Use The African Academy of Sciences has started work on the continent’s first cross-disciplinary guidelines on how to collect, store and share research data and specimens in ways that protect study participants from exploitation and benefit African citizens. [Nature News] Editorial Trump Issues Executive Order that Could Reduce Scientific Advice President Donald Trump issued an executive order on June 14 to cut back the number of advisory committees by at least a third by the end of September, according to a statement from the White House. The federal advisory committee system is the formal structure for government agencies to seek advice from experts including scientists. [The Scientist] Editorial China Clamps Down on Foreign Use of Chinese Genetic Material and Data China has announced new regulations for the use of human genetic resources that come from Chinese participants. The rules, announced on June 10, require international scientists using biomaterials from China to have a Chinese collaborator and go into effect on July 1. [The Scientist] Editorial
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EVENTSNEW 14th World Congress on Inflammation Sydney 2019 Visit our events page to see a complete list of events in the community.
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